Items where Author is "Rushworth, Stuart"

Article

Steverding, Dietmar, Rushworth, Stuart A., Hurle, Georgina R. ORCID: https://orcid.org/0000-0003-0033-2585, Antoszczak, Michał, Sulik, Michał, Huczyński, Adam and Tyler, Kevin M. ORCID: https://orcid.org/0000-0002-0647-8158 (2024) Increased trypanocidal activity of the salinomycin derivative ironomycin is due to ROS production and iron uptake impairment. Molecules, 29 (23). ISSN 1420-3049

Moreno-Gonzalez, Mar, Hampton, Katherine, Ruiz, Paula, Beasy, Gemma, Nagies, Falk S. P., Parker, Aimee, Lazenby, James, Bone, Caitlin, Alava-Arteaga, Ane, Patel, Meha, Hellmich, Charlotte, Luri-Martin, Pablo, Silan, Ece, Philo, Mark, Baker, David, Rushbrook, Simon M., Hildebrand, Falk, Rushworth, Stuart A. and Beraza, Naiara (2024) Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression. JHEP Reports, 6 (10). ISSN 2589-5559

Wojtowicz, Edyta E., Hampton, Katherine, Moreno-Gonzalez, Mar, Utting, Charlotte L., Lan, Yuxuan, Ruiz, Paula, Beasy, Gemma, Bone, Caitlin, Hellmich, Charlotte, Maynard, Rebecca, Acton, Luke, Markham, Matthew, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Telatin, Andrea, Kingsley, Robert A. ORCID: https://orcid.org/0000-0002-0194-6485, Macaulay, Iain C., Rushworth, Stuart A. and Beraza, Naiara (2024) Low protein diet protects the liver from Salmonella Typhimurium-mediated injury by modulating the mTOR/autophagy axis in macrophages. Communications Biology, 7. ISSN 2399-3642

Fowler-Shorten, Dominic J., Maynard, Rebecca S., Hampton, Katherine, Altera, Annalisa, Markham, Matthew, Ehikioya, Martha, Wojtowicz, Edyta E., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Rushworth, Stuart A. and Hellmich, Charlotte (2024) Acute myeloid leukemia driven IL-3-dependent upregulation of BCL2 in non-malignant hematopoietic stem and progenitor cells increases venetoclax-induced cytopenias. Haematologica, 109 (5). pp. 1576-1581. ISSN 0390-6078

Steverding, Dietmar, Tinson, Ryan A. J., Piras, Monica, Wren, Stephen P., Rushworth, Stuart A., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2024) Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug. Experimental Parasitology, 260. ISSN 0014-4894

Johnson, Benjamin B., Cosson, Marie-Victoire, Tsansizi, Lorenza I., Holmes, Terri L., Gilmore, Tegan, Hampton, Katherine, Song, Ok-Ryul, Vo, Nguyen T. N., Nasir, Aishah, Chabronova, Alzbeta, Denning, Chris, Peffers, Mandy J., Merry, Catherine L. R., Whitelock, John, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Rushworth, Stuart A., Bernardo, Andreia S. and Smith, James G. W. ORCID: https://orcid.org/0000-0003-0427-8678 (2024) Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes. Cell Reports, 43 (1). ISSN 2211-1247

Wojtowicz, Edyta E., Mistry, Jayna J., Uzun, Vladimir, Hellmich, Charlotte, Scoones, Anita, Chin, Desmond W., Kettyle, Laura M., Grasso, Francesca, Lord, Allegra M., Wright, David J., Etherington, Graham J., Woll, Petter S., Belderbos, Mirjam E., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Nerlov, Claus, Haerty, Wilfried ORCID: https://orcid.org/0000-0003-0111-191X, Bystrykh, Leonid V., Jacobsen, Sten Eirik W., Rushworth, Stuart A. and Macaulay, Iain C. (2023) Panhematopoietic RNA barcoding enables kinetic measurements of nucleate and anucleate lineages and the activation of myeloid clones following acute platelet depletion. Genome Biology, 24. ISSN 1474-760X

Jibril, Aisha, Hellmich, Charlotte, Wojtowicz, Edyta E., Hampton, Katherine, Maynard, Rebecca, De Silva, Ravindu ORCID: https://orcid.org/0009-0003-5184-5978, Fowler-Shorten, Dominic J., Mistry, Jayna J., Moore, Jamie A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2023) Plasma cell derived mtDAMPs activate macrophage STING pathway which promotes myeloma progression. Blood, 141 (25). 3065–3077. ISSN 0006-4971

Mincarelli, Laura, Uzun, Vladimir, Wright, David, Scoones, Anita, Rushworth, Stuart A., Haerty, Wilfried ORCID: https://orcid.org/0000-0003-0111-191X and Macaulay, Iain C. (2023) Single-cell gene and isoform expression analysis reveals signatures of ageing in haematopoietic stem and progenitor cells. Communications Biology, 6. ISSN 2399-3642

Hellmich, Charlotte, Wojtowicz, Edyta, Moore, Jamie A., Mistry, Jayna J., Jibril, Aisha, Johnson, Benjamin B., Smith, James G.W. ORCID: https://orcid.org/0000-0003-0427-8678, Beraza, Naiara, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2023) p16INK4A-dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors. Blood Advances, 7 (2). pp. 256-268. ISSN 2473-9529

Mistry, Jayna J., Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2023) HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis. Experimental Hematology, 117. pp. 1-8. ISSN 0301-472X

Kumar, Prakrit R., Saad, Mona, Hellmich, Charlotte, Mistry, Jayna J., Moore, Jamie A., Conway, Shannon, Morris, Christopher J. ORCID: https://orcid.org/0000-0002-7703-4474, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Moncrieff, Marc D. and Rushworth, Stuart A. (2022) PGC-1α induced mitochondrial biogenesis in stromal cells underpins mitochondrial transfer to melanoma. British Journal of Cancer, 127. 69–78. ISSN 0007-0920

Moore, Jamie A., Mistry, Jayna J., Hellmich, Charlotte, Horton, Rebecca H., Wojtowicz, Edyta E., Jibril, Aisha, Jefferson, Matthew, Wileman, Thomas, Beraza, Naiara, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2022) LC3-associated phagocytosis in bone marrow macrophages suppresses acute myeloid leukemia progression through STING activation. Journal of Clinical Investigation, 132 (5). ISSN 0021-9738

Isaacs-Ten, Anna, Moreno-Gonzalez, Mar, Bone, Caitlin, Martens, Andre, Bernuzzi, Federico, Ludwig, Tobias, Hellmich, Charlotte, Hiller, Karsten, Rushworth, Stuart A. and Beraza, Naiara (2022) Metabolic regulation of macrophages by SIRT1 determines activation during cholestatic liver disease in mice. Cellular and Molecular Gastroenterology and Hepatology, 13 (4). pp. 1019-1039. ISSN 2352-345X

Johnson, Benjamin, Reinhold, Johannes ORCID: https://orcid.org/0000-0003-2412-2574, Holmes, Terri, Moore, Jamie A., Cowell, Verity, Bernardo, Andreia S., Rushworth, Stuart, Vassiliou, Vassilios ORCID: https://orcid.org/0000-0002-4005-7752 and Smith, James ORCID: https://orcid.org/0000-0003-0427-8678 (2022) Modelling metabolic shifts during cardiomyocyte differentiation, iron deficiency and transferrin rescue using human pluripotent stem cells. Metabolites, 12 (1). ISSN 2218-1989

Mistry, Jayna J., Hellmich, Charlotte, Moore, Jamie A., Jibril, Aisha, Macaulay, Iain, Moreno-Gonzalez, Mar, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2021) Free fatty-acid transport via CD36 drives β-oxidation-mediated hematopoietic stem cell response to infection. Nature Communications, 12 (1). ISSN 2041-1723

Mistry, Jayna J, Hellmich, Charlotte, Lambert, Amelia, Moore, Jamie A, Jibril, Aisha, Collins, Angela, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A (2021) Venetoclax and Daratumumab combination treatment demonstrates pre-clinical efficacy in mouse models of Acute Myeloid Leukemia. Biomarker Research, 9 (1). ISSN 2050-7771

Teresa Borrello, Maria, Benelkebir, Hanae, Lee, Adam, Hin Tam, Chak, Shafat, Manar, Rushworth, Stuart A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Douglas, Leon, Duriez, Patrick J., Bailey, Sarah, Crabb, Simon J., Packham, Graham and Ganesan, A. ORCID: https://orcid.org/0000-0003-4862-7999 (2021) Synthesis of carboxamide-containing tranylcypromine analogues as LSD1 (KDM1A) inhibitors targeting acute myeloid leukemia. ChemMedChem, 16 (8). pp. 1316-1324. ISSN 1860-7179

Whitfield, Hayley, Hemmings, Andrew M. ORCID: https://orcid.org/0000-0003-3053-3134, Mills, Stephen J., Baker, Kendall, White, Gaye, Rushworth, Stuart, Riley, Andrew M., Potter, Barry V. L. and Brearley, Charles A. ORCID: https://orcid.org/0000-0001-6179-9109 (2021) Allosteric site on SHIP2 identified through fluorescent ligand screening and crystallography: a potential new target for intervention. Journal of Medicinal Chemistry, 64 (7). 3813–3826. ISSN 0022-2623

Berger Gillam, Tara, Cole, Jennifer, Gharbi, Karim, Angiolini, Emily, Barker, Tom, Bickerton, Peter, Brabbs, Thomas, Chin, Jeannette ORCID: https://orcid.org/0000-0002-9398-5579, Coen, Enrico, Cossey, Sarah, Davey, Robert P., Davidson, Rosemary ORCID: https://orcid.org/0000-0002-6624-4011, Durrant, Alex, Edwards, Dylan ORCID: https://orcid.org/0000-0002-3292-2064, Hall, Neil, Henderson, Suzanne, Hitchcock, Mark, Irish, Naomi, Lipscombe, James, Jones, Greg, Parr, Gerard ORCID: https://orcid.org/0000-0002-9365-9132, Rushworth, Stuart, Shearer, Neil, Smith, Russell and Steel, Nicholas ORCID: https://orcid.org/0000-0003-1528-140X (2021) Norwich COVID-19 testing initiative pilot: evaluating the feasibility of asymptomatic testing on a university campus. Journal of Public Health, 43 (1). pp. 82-88. ISSN 1741-3842

Gillam, T. Berger, Cole, J., Gharbi, K., Angiolini, E., Barker, T., Bickerton, P., Brabbs, T., Chin, J. ORCID: https://orcid.org/0000-0002-9398-5579, Coen, E., Cossey, S., Davey, R., Davidson, R. ORCID: https://orcid.org/0000-0002-6624-4011, Durrant, A., Edwards, D. ORCID: https://orcid.org/0000-0002-3292-2064, Hall, N. ORCID: https://orcid.org/0000-0003-2808-0009, Henderson, S., Hitchcock, M., Irish, N., Lipscombe, J., Jones, G., Parr, G. ORCID: https://orcid.org/0000-0002-9365-9132, Rushworth, S., Shearer, N., Smith, R. and Steel, N. ORCID: https://orcid.org/0000-0003-1528-140X (2021) Norwich COVID-19 testing initiative pilot: evaluating the feasibility of asymptomatic testing on a university campus. Journal of Public Health, 43 (1). pp. 82-88. ISSN 1741-3842

Mistry, Jayna J., Moore, Jamie A., Kumar, Prakritt, Marlein, Christopher R., Hellmich, Charlotte, Pillinger, Genevra, Jibril, Aisha, Di Palma, Federica, Collins, Angela, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2021) Daratumumab inhibits acute myeloid leukemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells. Haematologica, 106 (2). pp. 589-592. ISSN 0390-6078

Kumar, Prakrit R., Moore, Jamie A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Rushworth, Stuart A. and Moncrieff, Marc D. (2021) Mitochondrial oxidative phosphorylation in cutaneous melanoma. British Journal of Cancer, 124 (1). pp. 115-123. ISSN 0007-0920

Hellmich, Charlotte, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2020) ARQ531: The therapy that targets multiple pathways in acute myeloid leukemia. Haematologica, 105 (10). pp. 2350-2352. ISSN 0390-6078

Hellmich, Charlotte, Moore, Jamie A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2020) Bone marrow senescence and the microenvironment of hematological malignancies. Frontiers in Oncology, 10. ISSN 2234-943X

Steverding, Dietmar, Rushworth, Stuart, Florea, Bogdan I. and Overkleeft, Herman S. (2020) Trypanosoma brucei: inhibition of cathepsin L is sufficient to kill bloodstream forms. Molecular and Biochemical Parasitology, 235. ISSN 0166-6851

Horton, Rebecca, Wileman, Thomas and Rushworth, Stuart A (2020) Autophagy driven extracellular vesicles in the leukaemic microenvironment. Current Cancer Drug Targets, 20 (7). 501 - 512. ISSN 1568-0096

Mistry, Jayna J., Marlein, Christopher R., Moore, Jamie A., Hellmich, Charlotte, Wojtowicz, Edyta E., Smith, James G. W. ORCID: https://orcid.org/0000-0003-0427-8678, Macaulay, Iain, Sun, Yu, Morfakis, Adam, Patterson, Angela, Horton, Rebecca H., Divekar, Devina, Morris, Christopher J. ORCID: https://orcid.org/0000-0002-7703-4474, Haestier, Anna, Di Palma, Federica, Beraza, Naiara, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2019) ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection. Proceedings of the National Academy of Sciences of the United States of America, 116 (49). pp. 24610-24619. ISSN 1091-6490

Bhatti, Maria, Ayton, Sarah, Michail, Olga, Gollop, Nicholas D., Ryding, Alisdair, Rushworth, Stuart, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526, Geisler, Tobias and Flather, Marcus (2019) Effect of Bruton's tyrosine kinase inhibitors on platelet aggregation in patients with acute myocardial infarction. Thrombosis Research, 179. pp. 64-68. ISSN 0049-3848

Marlein, Christopher, Piddock, Rachel E., Mistry, Jayna J., Zaitseva, Lyubov, Hellmich, Charlotte, Horton, Rebecca H., Zhou, Zhigang, Auger, Martin J., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2019) CD38-driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma. Cancer Research, 79 (9). pp. 2285-2297. ISSN 0008-5472

Abdul-Aziz, Amina M, Sun, Yu, Hellmich, Charlotte, Marlein, Christopher R, Mistry, Jayna, Forde, Eoghan, Piddock, Rachel E, Shafat, Manar S, Morfakis, Adam, Mehta, Tarang, Di Palma, Federica, Macaulay, Iain, Ingham, Christopher J, Haestier, Anna, Collins, Angela, Campisi, Judith, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A (2019) Acute myeloid leukemia induces pro-tumoral p16INK4a driven senescence in the bone marrow microenvironment. Blood, 133 (5). pp. 446-456. ISSN 0006-4971

Bhatti, M., Michail, O., Ayton, S., Gollop, N. D., Ryding, A., Rushworth, S., Bowles, K. ORCID: https://orcid.org/0000-0003-1334-4526 and Flather, M. (2018) Potential for Bruton's tyrosine kinase inhibitors as additional antiplatelet agents in acute coronary syndromes. European Heart Journal, 39 (Supplement 1). p. 747. ISSN 0195-668X

Marlein, Christopher, Zaitseva, Lyubov, Piddock, Rachel, Raso-Barnett, Livia, Scott, Michael, Ingham, Christopher, Collins, Angela, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2018) PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts. Leukemia, 32. 2073–2077. ISSN 0887-6924

Bhatti, Maria, Ayton, Sarah, Michail, Olga, Gollop, Nicholas D., Ryding, Alisdair, Rushworth, Stuart, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Flather, Marcus (2018) The effect of BTK inhibitors on platelet aggregation in acute coronary syndromes. Heart, 104. A7-A8. ISSN 1355-6037

Piddock, Rachel E., Marlein, Christopher R., Abdul-Aziz, Amina, Shafat, Manar S., Auger, Martin J., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2018) Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC. Journal of Hematology & Oncology, 11. ISSN 1756-8722

Piddock, Rachel E., Marlein, Christopher R., Abdul-Aziz, Amina, Shafat, Manar S., Auger, Martin J., Bowles, Kristian M. and Rushworth, Stuart A. (2018) Myeloma-derived macrophage inhibitory factor regulates bone marrow stromal cell-derived IL-6 via c-MYC. Journal of Hematology & Oncology, 11. ISSN 1756-8722

Sun, Yu, Abdul Aziz, Amina, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2018) High NRF2 expression controls endoplasmic reticulum stress induced apoptosis in multiple myeloma. Cancer Letters, 412. pp. 37-45. ISSN 0304-3835

Abdul-Aziz, Amina M., Shafat, Manar S., Sun, Yu, Marlein, Christopher R., Piddock, Rachel E., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Zhou, Zhigang, Collins, Angela, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2018) HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene, 37. 2676–2686. ISSN 0950-9232

Marlein, Christopher R., Zaitseva, Lyubov, Piddock, Rachel E., Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan ORCID: https://orcid.org/0000-0002-3292-2064, Shafat, Manar S., Zhou, Zhigang, Lawes, Matthew, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts. Blood, 130 (14). pp. 1649-1660. ISSN 0006-4971

Shafat, Manar S., Gnaneswaran, Bruno, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) The bone marrow microenvironment – Home of the leukemic blasts. Blood Reviews, 31 (5). 277–286. ISSN 0268-960X

Steverding, Dietmar and Rushworth, Stuart A. (2017) Front-line glioblastoma chemotherapeutic temozolomide is toxic to Trypanosoma brucei and potently enhances melarsoprol and eflornithine. Experimental Parasitology, 178. 45–50. ISSN 0014-4894

Chandran, Sujay, Watkins, Johnathan, Abdul‐Aziz, Amina, Shafat, Manar, Calvert, Patrick A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Flather, Marcus D., Rushworth, Stuart A. and Ryding, Alisdair D. (2017) Inflammatory differences in plaque erosion and rupture in patients with ST-segment elevation myocardial infarction. Journal of the American Heart Association, 6 (5). ISSN 2047-9980

Piddock, Rachel E., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) The role of PI3K isoforms in regulating bone marrow microenvironment signaling focusing on acute myeloid leukemia and multiple myeloma. Cancers, 9 (4). ISSN 2072-6694

Piddock, R E, Loughran, N, Marlein, C R, Robinson, S D ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, D R ORCID: https://orcid.org/0000-0002-3292-2064, Yu, S, Pillinger, G E, Zhou, Z, Zaitseva, L, Auger, M J, Rushworth, S A and Bowles, K M ORCID: https://orcid.org/0000-0003-1334-4526 (2017) PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment. Blood Cancer Journal, 7 (3). ISSN 2044-5385

Shafat, Manar S., Oellerich, Thomas, Mohr, Sebastian, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Marlein, Christopher R., Piddock, Rachel E., Fenech, Matthew, Zaitseva, Lyubov, Abdul-Aziz, Amina, Turner, Jeremy, Watkins, Johnathan A., Lawes, Matthew, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment. Blood, 129 (10). pp. 1320-1332. ISSN 0006-4971

Abdul-Aziz, Amina, Shafat, Manar, Mehta, Tarang, Di Palma, Federica, Lawes, Matthew, Rushworth, Stuart A. and Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 (2017) MIF-induced stromal PKCβ/IL8 is essential in human acute myeloid leukemia. Cancer Research, 77 (2). pp. 303-311. ISSN 0008-5472

Steverding, Dietmar, da Nóbrega, Flávio Rogério, Rushworth, Stuart A. and de Sousa, Damião Pergentino (2016) Trypanocidal and cysteine protease inhibitory activity of isopentyl caffeate is not linked in Trypanosoma brucei. Parasitology Research, 115 (11). 4397–4403. ISSN 0932-0113

Pillinger, Genevra, Loughran, Niamh V., Piddock, Rachel E., Shafat, Manar S., Zaitseva, Lyubov, Abdul-Aziz, Amina, Lawes, Matthew J., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2016) Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection. Oncotarget, 7 (26). pp. 39784-39795. ISSN 1949-2553

Pillinger, Genevra, Abdul-Aziz, Amina, Zaitseva, Lyubov, Lawes, Matt, MacEwan, David, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2015) Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia. Scientific Reports, 5. ISSN 2045-2322

Murray, Megan Y., Zaitseva, Lyubov, Auger, Martin J., Craig, Jenny I.O., MacEwan, David, Rushworth, Stuart A. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2015) Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma. Cell Cycle, 14 (14). pp. 2367-2375. ISSN 1538-4101

Rushworth, Stuart A., Pillinger, Genevra, Abdul-Aziz, Amina, Piddock, Rachel, Shafat, Manar S., Murray, Megan Y., Zaitseva, Lyubov, Lawes, Matthew J., MacEwan, David J. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2015) Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells. The Lancet Haematology, 2 (5). e204-e211.

Shah, N. M., Zaitseva, L., Bowles, K. M. ORCID: https://orcid.org/0000-0003-1334-4526, MacEwan, D. J. and Rushworth, S. A. (2015) NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival. Cell Death and Differentiation, 22. pp. 654-664. ISSN 1350-9047

Zaitseva, Lyubov, Murray, Megan Y, Shafat, Manar S., Lawes, Matthew J, MacEwan, David J, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A (2014) Ibrutinib inhibits SDF1/CXCR4 mediated migration in AML. Oncotarget, 5 (20). pp. 9930-9938. ISSN 1949-2553

Rushworth, Stuart A., Murray, Megan Y., Zaitseva, Lyubov, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2014) Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia. Blood, 123 (8). pp. 1229-1238. ISSN 0006-4971

Rushworth, Stuart A., MacEwan, David J. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2013) Ibrutinib in relapsed chronic lymphocytic leukemia. New England Journal of Medicine, 369 (13). pp. 1277-1278. ISSN 1533-4406

Shah, Niraj M., Rushworth, Stuart, Murray, Megan A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2013) Understanding the role of NRF2-regulated miRNAs in human malignancies. Oncotarget, 4 (8). pp. 1130-1142. ISSN 1949-2553

Murray, Megan Y., Rushworth, Stuart A., Zaitseva, Lyubov, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2013) Attenuation of dexamethasone-induced cell death in multiple myeloma is mediated by miR-125b expression. Cell Cycle, 12 (13). pp. 2144-2153.

Rushworth, Stuart A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Barrera, Lawrence N., Murray, Megan Y., Zaitseva, Lyubov and MacEwan, David J. (2013) BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB. Cellular Signalling, 25 (1). pp. 106-112.

MacEwan, David, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2013) Emerging therapy targeting tyrosine-protein kinase BTK: potential for ibrutinib and other BTK inhibitors. Drugs of the Future, 38 (8). pp. 569-573. ISSN 2013-0368

Rushworth, Stuart A., Zaitseva, Lyubov, Murray, Megan Y., Shah, Niraj M., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2012) The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance. Blood, 120 (26). pp. 5188-5198. ISSN 0006-4971

Barrera, Lawrence N., Rushworth, Stuart A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2012) Bortezomib induces heme oxygenase-1 expression in multiple myeloma. Cell Cycle, 11 (12). pp. 2248-2252. ISSN 1538-4101

Rushworth, Stuart A., Murray, Megan Y., Barrera, Lawrence N., Heasman, Sally-Anne, Zaitseva, Lyubov and MacEwan, David J. (2012) Understanding the role of miRNA in regulating NF-kB in blood cancer. American Journal of Cancer Research, 2 (1). pp. 65-74. ISSN 2156-6976

Murray, Megan Y., Rushworth, Stuart A. and MacEwan, David J. (2011) Micro RNAs as a new therapeutic target towards leukaemia signalling. Cellular Signalling, 24 (2). pp. 363-368.

Barrera, L. N., Rushworth, S. A. and MacEwan, D. J. (2011) Regulation of heme oxygenase-1 (HO-1) by gene promoter methylation in acute myeloid leukaemia. Basic & Clinical Pharmacology & Toxicology, 109. p. 96. ISSN 1742-7843

Heasman, S.-A., Zaitseva, L., Bowles, K. ORCID: https://orcid.org/0000-0003-1334-4526, Rushworth, S. A. and MacEwan, D. J. (2011) Heme oxygenase-1 protects acute myeloid leukaemia cells from front line chemotherapeutic drugs. Basic & Clinical Pharmacology & Toxicology, 109. p. 96. ISSN 1742-7843

Rushworth, S. A., Bowles, K. M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, D. J. (2011) Elevated NRF2 levels in acute myeloid leukaemia reduces sensitivity towards proteasome inhibitors. Basic & Clinical Pharmacology & Toxicology, 109. p. 31. ISSN 1742-7843

Zaitseva, L., Rushworth, S. A. and MacEwan, D. J. (2011) Regulation of Apoptotic signaling by flip modulatory proteins. Basic & Clinical Pharmacology & Toxicology, 109. p. 58. ISSN 1742-7843

Heasman, Sally-Anne, Zaitseva, Lyubov, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526, Rushworth, Stuart A. and MacEwan, David J. (2011) Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1. Oncotarget, 2 (9). pp. 658-668.

Rushworth, Stuart A., Shah, Suharsh and MacEwan, David J. (2011) TNF mediates the sustained activation of Nrf2 in human monocytes. Journal of Immunology, 187 (2). pp. 702-707. ISSN 0022-1767

Zaitseva, Lyubov, Rushworth, Stuart A. and MacEwan, David J. (2011) Silencing FLIPL modifies TNF-induced apoptotic protein expression. Cell Cycle, 10 (7). pp. 1067-1072. ISSN 1538-4101

Rushworth, Stuart A. and MacEwan, David J. (2011) The role of Nrf2 and cytoprotection in regulating chemotherapy resistance of human leukemia cells. Cancers, 3 (2). pp. 1605-1621. ISSN 2072-6694

Rushworth, Stuart A., Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2011) High basal nuclear levels of Nrf2 in acute myeloid leukemia reduces sensitivity to proteasome inhibitors. Cancer Research, 71 (5). pp. 1999-2009. ISSN 0008-5472

Rushworth, Stuart A, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Raninga, Prahlad and MacEwan, David J (2010) NF-kappaB-inhibited acute myeloid leukemia cells are rescued from apoptosis by heme oxygenase-1 induction. Cancer Research, 70 (7). pp. 2973-2983. ISSN 0008-5472

Rushworth, Stuart A., Zaitseva, Lyubov, Langa Marcano, Susana, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and MacEwan, David J. (2010) FLIP regulation of HO-1 and TNF signalling in human acute myeloid leukemia provides a unique secondary anti-apoptotic mechanism. Oncotarget, 1 (5). pp. 359-366. ISSN 1949-2553

White, H., Norton, R., Rushworth, S. A., Mc Carthy, E. and O'Connell, M. A. ORCID: https://orcid.org/0000-0002-0267-0951 (2010) LPS activation of the Nrf2 pathway in monocytes: role of PKC alpha. Immunology, 131. pp. 146-147. ISSN 0019-2805

Rushworth, Stuart A., MacEwan, David J. and O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951 (2008) Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes. Journal of Immunology, 181 (10). pp. 6730-6737. ISSN 0022-1767

Rushworth, SA, Macewan, DJ and O'Connell, MA (2008) Lipopolysaccharide induced expression of NQO1 and HO-1 protects against excessive inflammatory responses. The Journal of Immunology, 181 (10). pp. 6730-6737. ISSN 0022-1767

Ogborne, Richard M., Rushworth, Stuart and O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951 (2008) Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cδ and Nrf2. Biochemical and Biophysical Research Communications, 373 (4). pp. 584-588. ISSN 1090-2104

Rushworth, Stuart A. and MacEwan, David J. (2008) HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood, 111 (7). pp. 3793-3801. ISSN 0006-4971

O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951 and Rushworth, Stuart (2008) Curcumin: potential for hepatic fibrosis therapy? British Journal of Pharmacology, 153 (3). pp. 403-405. ISSN 1476-5381

Rushworth, Stuart A., Taylor, Alison, Langa, Susana and MacEwan, David J. (2008) TNF signaling gets FLIPped off : TNF-induced regulation of FLIP. Cell Cycle, 7 (2). pp. 194-199. ISSN 1538-4101

Ogborne, R. M., Rushworth, S. A. and O'Connell, M. A. ORCID: https://orcid.org/0000-0002-0267-0951 (2005) alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 25 (10). pp. 2100-2105. ISSN 1079-5642

Rushworth, Stuart A., Chen, Xi-Lin, Mackman, Nigel, Ogborne, Richard M. and O'Connell, Maria A. ORCID: https://orcid.org/0000-0002-0267-0951 (2005) Lipopolysaccharide-induced heme oxygenase-1 expression in human monocytic cells is mediated via Nrf2 and protein kinase C. Journal of Immunology, 175 (7). pp. 4408-4415. ISSN 0022-1767

Ogborne, R. M., Rushworth, S. A., Charalambos, C. A. and O'Connell, M. A. ORCID: https://orcid.org/0000-0002-0267-0951 (2004) Haem oxygenase-1: a target for dietary antioxidants. Biochemical Society Transactions, 32 (6). pp. 1003-1005. ISSN 0300-5127

Rushworth, S. A. and O'Connell, M. A. ORCID: https://orcid.org/0000-0002-0267-0951 (2004) Haem oxygenase-1 in inflammation. Biochemical Society Transactions, 32 (6). pp. 1093-1094. ISSN 0300-5127

Book Section

Mistry, Jayna J. and Rushworth, Stuart A. (2023) In Vivo Imaging of Bone Marrow Long-Chain Fatty Acid Uptake. In: Methods in Molecular Biology. Methods in Molecular Biology . Humana Press Inc, pp. 43-49. ISBN 978-1-0716-3246-8

Moore, Jamie A., Mistry, Jayna J. and Rushworth, Stuart A. (2021) Mitochondria and the Tumour Microenvironment in Blood Cancer. In: Tumor Microenvironment. Tumor Microenvironment . UNSPECIFIED, pp. 181-203. ISBN 978-3-030-73118-2

Rushworth, S. A. and MacEwan, D. J. (2011) The interrelationship between NF-kappaB, Nrf2 and Keap1 in controlling TNF induced inflammatory responses. In: Advances in TNF family research. Advances in Experimental Medicine and Biology, 691 . UNSPECIFIED, pp. 666-667. ISBN 978-1-4419-6611-7

White, H, Norton, R, Rushworth, SA, Mc Carthy, E and O'Connell, MA ORCID: https://orcid.org/0000-0002-0267-0951 (2010) LPS activation of the Nrf2 pathway in monocytes: role of PKC alpha. In: Immunity. UNSPECIFIED, pp. 146-147.

O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Ogborne, Richard M., Rushworth, Stuart, Harvey, Glynn and Schipper, J (2005) Effect of dietary antioxidants on glutamate cysteine ligse modulator sub-unit gene expression in human THP-1 cells. In: Proceedings of the Nutrition Society. UNSPECIFIED, 67A.

O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Rushworth, Stuart and Everett, Katy (2004) Dietary polyphenols differentially regulate CD40-mediated VCAM1 and tissue factor mRNA expression in human endothelial cells. In: Proceedings of the Nutrition Society. UNSPECIFIED, 34A.

Conference or Workshop Item

Jibril, Aisha, Hellmich, Charlotte, Moore, Jamie A., Mistry, Jayna, Rushworth, Stuart, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Willimott, Victoria (2021) Multiple myeloma derived mitochondrial damps induce inflammation in the bone marrow adipose tissue which promotes tumour development. In: UNSPECIFIED.