Items where Author is "Wormstone, Michael"

Article

Hidalgo-Alvarez, Veronica, Falcon, Noelia D., Eldred, Julie, Wormstone, Michael and Saeed, Aram (2024) Stereolithographic rapid prototyping of clear, foldable, non-refractive intraocular lens designs: A proof-of-concept study. Current Eye Research, 49 (8). pp. 843-852. ISSN 1460-2202

Huynh, Thao Phuong Ngoc, Bowater, Richard P., Bernuzzi, Federico, Saha, Shikha and Wormstone, I. Michael (2021) GSH levels serve as a biological redox switch regulating sulforaphane-induced cell fate in human lens cells. Investigative Ophthalmology and Visual Science, 62 (15). ISSN 0146-0404

Baranowska, Monika, Koziara, Zuzanna, Suliborska, Klaudia, Chrzanowski, Wojciech, Wormstone, Michael, Namieśnik, Jacek and Bartoszek, Agnieszka (2021) Interactions between polyphenolic antioxidants quercetin and naringenin dictate the distinctive redox-related chemical and biological behaviour of their mixtures. Scientific Reports, 11. ISSN 2045-2322

Wormstone, Michael (2021) Fluorofenidone inhibits the epithelial-mesenchymal transition in human lens epithelial cell line FHL 124: a promising therapeutic strategy against posterior capsular opacification. Arquivos Brasileiros de Oftalmologia, 84 (3). ISSN 0004-2749

Wormstone, I. M., Wormstone, Y. M., Smith, A. J. O. and Eldred, J. A. (2021) Posterior capsule opacification: What's in the bag? Progress in Retinal and Eye Research, 82. ISSN 1350-9462

Huangfu, Jingru, Hao, Caili, Wei, Zongbo, Wormstone, I. Michael, Yan, Hong and Fan, Xingjun (2021) Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells. Cell Death & Disease, 12 (4). ISSN 2041-4889

Wormstone, I. Michael, Damm, Niklas B., Kelp, Martin and Eldred, Julie A. (2021) Assessment of intraocular lens/capsular bag biomechanical interactions following cataract surgery in a human in vitro graded culture capsular bag model. Experimental Eye Research, 205. ISSN 0014-4835

Nam, Mi-Hyun, Smith, Andrew J. O., Pantcheva, Mina B., Park, Ko Uoon, Brzezinski Iv, Joseph A., Galligan, James J., Fritz, Kristofer, Wormstone, I. Michael and Nagaraj, Ram H. (2020) Aspirin inhibits TGFβ2-induced epithelial to mesenchymal transition of lens epithelial cells: Selective acetylation of K56 and K122 in histone H3. Biochemical Journal, 477 (1). pp. 75-97. ISSN 0264-6021

Wormstone, Michael (2020) The human capsular bag model of posterior capsule opacification. Eye, 34 (2). pp. 225-231. ISSN 0950-222X

Liu, Hanruo, Li, Liu, Wormstone, Michael, Qiao, Chunyan, Zhang, Chunjian, Liu, Ping, Li, Shuning, Wang, Huaizhou, Mou, Dapeng, Pang, Ruiqi, Yang, Diya, Jiang, Lai, Chen, Yihan, Hu, Man, Xu, Yongli, Kang, Hong, Ji, Xin, Chang, Robert, Tham, Clement, Cheung, Carol, Wei Ting, Daniel Shu, Wong, Tien Yin, Wang, Zulin, Weinreb, Robert, Xu, Mai and Wang, Ningli (2019) Development and validation of a deep learning system to detect glaucomatous optic neuropathy using fundus photographs. JAMA Ophthalmology, 137 (12). pp. 1353-1360. ISSN 2168-6165

Smith, Andrew, Eldred, Julie and Wormstone, Michael (2019) Resveratrol inhibits wound-healing and lens fibrosis: A putative candidate for posterior capsule opacification prevention. Investigative Ophthalmology & Visual Science, 60. pp. 3863-3877. ISSN 0146-0404

Eldred, Julie A., Zheng, Jiyun, Chen, Sulin and Wormstone, I. Michael (2019) An in vitro human lens capsular bag model adopting a graded culture regime to assess putative impact of IOLs on PCO formation. Investigative Ophthalmology and Visual Science, 60 (1). pp. 113-122. ISSN 0146-0404

Liu, Peng, Wang, Wei, Zhou, Zhigang, Smith, Andrew, Bowater, Richard P., Wormstone, Ian Michael, Chen, Yuqiong and Bao, Yongping (2018) Chemopreventive activities of sulforaphane and its metabolites in human hepatoma HepG2 cells. Nutrients, 10 (5). ISSN 2072-6643

Liu, Hanruo, Smith, Andrew J. O., Ball, Simon S. R., Bao, Yongping, Bowater, Richard P., Wang, Ningli and Wormstone, I. Michael (2017) Sulforaphane promotes ER stress, autophagy and cell death: implications for cataract surgery. Journal of Molecular Medicine, 95 (5). 553–564. ISSN 0946-2716

Liao, Xin, Walden, Grace, Falcon, Noelia D., Donell, Simon, Raxworthy, Mike, Wormstone, Michael, Riley, Graham P. and Saeed, Aram (2017) A direct comparison of linear and star-shaped poly(dimethylaminoethyl acrylate) polymers for polyplexation with DNA and cytotoxicity in cultured cell lines. European Polymer Journal, 87. 458–467. ISSN 0014-3057

Smith, Andrew, Ball, Simon, Bowater, Richard and Wormstone, Ian (2016) PARP-1 inhibition influences the oxidative stress response of the human lens. Redox Biology, 8. pp. 354-362. ISSN 2213-2317

Raghavan, Cibin, Smuda, Mareen, Smith, Andrew, Howell, Scott, Smith, Dawn, Singh, Annapurna, Gupta, Pankaj, Glomb, Marcus, Wormstone, Ian and Nagaraj, Ram (2016) AGEs in human lens capsule promote the TGFβ2-mediated EMT of lens epithelial cells:Implications for age-associated fibrosis. Aging Cell, 15 (3). 465–476. ISSN 1474-9718

Eldred, Julie A., McDonald, Matthew, Wilkes, Helen S., Spalton, David J. and Wormstone, I. Michael (2016) Growth factor restriction impedes progression of wound healing following cataract surgery: identification of VEGF as a putative therapeutic target. Scientific Reports, 6. ISSN 2045-2322

Smith, Andrew F., Klotz, Alexander and Wormstone, I. Michael (2016) Improving the drug development process by reducing the impact of adverse events: The case of cataracts considered. Drug Discovery Today, 21 (3). pp. 510-516. ISSN 1359-6446

Wormstone, Ian Michael and Eldred, Julie Ann (2016) Experimental models for posterior capsule opacification research. Experimental Eye Research, 142. pp. 2-12. ISSN 0014-4835

Smith, Andrew John Oliver, Ball, Simon Sidney Robert, Manzar, Kamal, Bowater, Richard Peter and Wormstone, Ian Michael (2015) Ku80 counters oxidative stress-induced DNA damage and cataract formation in the human lens. Investigative Ophthalmology and Visual Science, 56 (13). pp. 7868-7874. ISSN 0146-0404

Eldred, Julie A., Spalton, David J. and Wormstone, I. Michael (2014) An in vitro evaluation of the Anew Zephyr ppen-bag IOL in the prevention of posterior capsule opacification using a human capsular bag model. Investigative Ophthalmology and Visual Science, 55 (11). pp. 7057-7064. ISSN 0146-0404

Spalton, David J., Russell, Sarah L., Evans-Gowing, Richard, Eldred, Julie A. and Wormstone, I. Michael (2014) Effect of total lens epithelial cell destruction on intraocular lens fixation in the human capsular bag. Journal of Cataract and Refractive Surgery, 40 (2). pp. 306-312. ISSN 0886-3350

Liu, Hanruo, Smith, Andrew J. O., Lott, Martin C., Bao, Yongping, Bowater, Richard P., Reddan, John R. and Wormstone, Ian Michael (2013) Sulforaphane can protect lens cells against oxidative stress: Implications for cataract prevention. Investigative Ophthalmology & Visual Science, 54 (8). pp. 5236-5248. ISSN 0146-0404

Fang, Chunlai, Illingworth, Christopher D., Qian, Limin and Wormstone, I. Michael (2013) Serum deprivation can suppress receptor-mediated calcium signaling in pterygial-derived fibroblasts. Investigative Ophthalmology & Visual Science, 54 (7). pp. 4563-4570. ISSN 0146-0404

Dawes, Lucy Jean, Duncan, George and Wormstone, Ian Michael (2013) Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery. Investigative Ophthalmology & Visual Science, 54 (1). pp. 333-42. ISSN 0146-0404

Wang, Lixin, Eldred, Julie A, Sidaway, Peter, Sanderson, Julie, Smith, Andrew J. O., Bowater, Richard P, Reddan, John R and Wormstone, I Michael (2012) Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens. Mechanisms of Ageing and Development, 133 (11-12). pp. 665-674. ISSN 0047-6374

Rhodes, Jeremy D., Lott, Martin C., Russell, Sarah L., Moulton, Vincent, Sanderson, Julie, Wormstone, I. Michael and Broadway, David C. (2012) Activation of the innate immune response and interferon signalling in myotonic dystrophy type 1 and type 2 cataracts. Human Molecular Genetics, 21 (4). pp. 852-862. ISSN 1460-2083

Dawes, Lucy J., Illingworth, Christopher D. and Wormstone, I. Michael (2012) A fully human in vitro capsular bag model to permit intraocular lens evaluation. Investigative Ophthalmology & Visual Science, 53 (1). pp. 23-29. ISSN 1552-5783

Eldred, Julie A., Hodgkinson, Lisa M., Dawes, Lucy J., Reddan, John R., Edwards, Dylan R. and Wormstone, I. Michael (2012) MMP2 activity is critical for TGF 2-induced matrix contraction--Implications for fibrosis. Investigative Ophthalmology & Visual Science, 53 (7). pp. 4085-4098. ISSN 0146-0404

Eldred, J. A., Dawes, L. J. and Wormstone, I. M. (2011) The lens as a model for fibrotic disease. Philosophical Transactions of the Royal Society B: Biological Sciences, 366 (1568). pp. 1301-1319. ISSN 0962-8436

Hodgkinson, Lisa M., Wang, Lixin, Duncan, George, Edwards, Dylan R. and Wormstone, I. Michael (2010) ADAM and ADAMTS gene expression in native and wound healing human lens epithelial cells. Molecular Vision, 16. pp. 2765-2776. ISSN 1090-0535

Rhodes, Jeremy D., Russell, Sarah L., Illingworth, Christopher D., Duncan, George and Wormstone, I. Michael (2009) Regional differences in store-operated Ca2+ entry in the epithelium of the intact human lens. Investigative Ophthalmology & Visual Science, 50 (9). pp. 4330-4336. ISSN 0146-0404

Dawes, Lucy Jean, Sleeman, Matthew Alexander, Anderson, Ian Keith, Reddan, John R. and Wormstone, Ian Michael (2009) TGF /Smad4-dependent and -independent regulation of human lens epithelial cells. Investigative Ophthalmology & Visual Science, 50 (11). pp. 5318-5327. ISSN 0146-0404

Wormstone, Michael, Wang, Lixin and Liu, Christopher S.C. (2009) Posterior capsule opacification. Experimental Eye Research, 88 (2). pp. 257-269. ISSN 1096-0007

Dawes, Lucy Jean, Eldred, Julie Ann, Anderson, Ian Kevin, Sleeman, Matthew, Reddan, John R., Duncan, George and Wormstone, Ian Michael (2008) TGF-induced contraction is not promoted by fibronectin-fibronectin receptor interaction, or SMA expression. Investigative Ophthalmology & Visual Science, 49 (2). pp. 650-661. ISSN 0146-0404

Dawes, L, Ellliott, RM, Reddan, JR, Wormstone, YM and Wormstone, IM (2007) Oligonucleotide regulated gene microarray analysis of human lens epithelial cells: TGF expression. Molecular Vision, 13. pp. 1181-1197. ISSN 1090-0535

Dawes, L.J., Angell, H., Sleeman, M., Reddan, J.R. and Wormstone, I.M. (2007) TGFbeta isoform dependent Smad2/3 kinetics in human lens epithelial cells: A Cellomics analysis. Experimental Eye Research. ISSN 1096-0007

Duncan, George, Wang, Lixin, Neilson, Geoffrey J. and Wormstone, Ian Michael (2007) Lens cell survival after exposure to stress in the closed capsular bag. Investigative Ophthalmology and Visual Science, 48. pp. 2701-2707. ISSN 1552-5783

Grocott, Timothy, Frost, Victoria, Maillard, Marjorie, Johansen, Terje, Wheeler, Grant N., Dawes, Lucy J., Wormstone, I. Michael and Chantry, Andrew (2007) The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter. Nucleic Acids Research, 35 (3). pp. 890-901. ISSN 0305-1048

Hodgkinson, Lisa M., Duncan, George, Wang, Lixin, Pennington, Caroline J., Edwards, Dylan R. and Wormstone, I. Michael (2007) MMP and TIMP expression in quiescent, dividing and differentiating human lens cells. Investigative Ophthalmology and Visual Science, 48. pp. 4192-4199. ISSN 1552-5783

Zhang, Hong, Duncan, George, Wang, Lixin, Liu, Ping, Cui, Hao, Reddan, John R., Yang, Bao-Feng and Wormstone, Michael (2007) Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Experimental Eye Research, 85 (6). pp. 825-835. ISSN 1096-0007

Wormstone, I. Michael, Anderson, Ian K., Eldred, Julie A., Dawes, Lucy J. and Duncan, George (2006) Short-term exposure to transforming growth factor beta induces long-term fibrotic responses. Experimental Eye Research, 83 (5). pp. 1238-1245. ISSN 1096-0007

Wormstone, I. Michael, Collison, David J., Hanson, Simon P. and Duncan, George (2006) A focus on the human lens in vitro. Environmental Toxicology and Pharmacology, 21. pp. 215-221. ISSN 1872-7077

Wang, Lixin, Wormstone, I. Michael, Reddan, John R. and Duncan, George (2005) Growth factor receptor signalling in human lens cells: role of the calcium store. Experimental Eye Research, 80 (6). pp. 885-895. ISSN 1096-0007

Wormstone, I. M., Tamiya, S., Eldred, J. A., Lazaridis, K., Chantry, A., Reddan, J. R., Anderson, I. and Duncan, G. (2004) Characterisation of TGF-beta 2 signalling and function in a human lens cell line. Experimental Eye Research, 78 (3). pp. 705-714. ISSN 1096-0007

Collison, David J., Wang, Lixin, Wormstone, I. Michael and Duncan, George (2004) Spatial characteristics of receptor-induced calcium signaling in human lens capsular bags. Investigative Ophthalmology and Visual Science, 45. pp. 200-205. ISSN 1552-5783

Duncan, G., Tamiya, S. and Wormstone, I.M. (2004) Antagonistic effects of TGF beta and EGF on gene expression in the human lens capsular bag. Investigative Ophthalmology and Visual Science, 45. p. 2332. ISSN 1552-5783

Maidment, Jill M., Duncan, George, Tamiya, Shigeo, Collison, David J., Wang, Lixin and Wormstone, I. M (2004) Regional differences in tyrosine kinase receptor signalling components determine differential growth patterns in the human lens. Investigative Ophthalmology and Visual Science, 45 (5). pp. 1427-1435. ISSN 1552-5783

Wormstone, I.M., Maidment, J.M., Tamiya, S., Collison, D.J., Wang, L. and Duncan, G. (2004) Relationship between growth activity and expression of EGF receptor and downstream signalling proteins in the human lens. Investigative Ophthalmology and Visual Science, 45. p. 1710. ISSN 1552-5783

Duncan, G., Tamiya, S. and Wormstone, I.M. (2003) Dynamics of gene expression in the human lens capsular bag in response to transforming growth factor beta 2. Investigative Ophthalmology and Visual Science, 44. p. 4506. ISSN 1552-5783

Eldred, J.A., Sanderson, J., Wormstone, I.M., Reddan, J.R. and Duncan, G. (2003) Stress-induced ATP release from and growth modulation of human lens and retinal pigment epithelial cells. Biochemical Society Transactions, 31 (6). pp. 1213-1215. ISSN 1470-8752

Wang, L., Wormstone, I.M., Reddan, J.R. and Duncan, G. (2003) EGF receptor signalling in human lens cells: Dependence on a functional calcium store. Investigative Ophthalmology and Visual Science, 44. p. 4503. ISSN 1552-5783

Eldred, Julie A, Sanderson, Julie, Wormstone, Michael, Reddan, J. R. and Duncan, George (2002) Stress-induced ATP release and growth modulation of human lens and retinal pigment epithelial cells. Investigative Ophthalmology and Visual Science, 43. ISSN 1552-5783

Duncan, G., Wormstone, I. M., Tamiya, S. and Anderson, I. (2002) TGF beta 2 and EGF regulation of MMP 2 and 9 expression in the human lens capsular bag. Investigative Ophthalmology and Visual Science, 42. p. 5007. ISSN 1552-5783

Maidment, J.M., Wormstone, I.M., Wang, L., Reddan, J.R. and Duncan, G. (2002) EGF-induced changes of the signalling proteins ERK1/2 in human lens epithelial cells. Investigative Ophthalmology and Visual Science, 43. ISSN 1552-5783

Maini, Raj, Collison, David J., Maidment, Jill M., Davies, Peter D. and Wormstone, I. Michael (2002) Pterygial derived fibroblasts express functionally active histamine and epidermal growth factor receptors. Experimental Eye Research, 74 (2). pp. 237-244. ISSN 0014-4835

Wormstone, I. M., Anderson, I. and Duncan, C. (2002) Short-term TGF beta 2 exposure mediates long-term changes in the human lens capsular bag. Investigative Ophthalmology and Visual Science, 43. ISSN 1552-5783

Wormstone, I. Michael (2002) Posterior capsule opacification: A cell biological perspective. Experimental Eye Research, 74. pp. 337-347. ISSN 1096-0007

Wormstone, I. Michael, Tamiya, Shigeo, Anderson, Ian and Duncan, George (2002) TGF beta2 induced matrix modification and cell transdifferentiation in the human lens capsular bag. Investigative Ophthalmology & Visual Science, 43 (7). pp. 2301-2308. ISSN 0146-0404

Wormstone, I.M., Tamiya, S., Eldred, Julie, Reddan, J.R., Anderson, J. and Duncan, G. (2002) Inhibition of TGF beta 2 mediated effects on human lens epithelial cells by the human monoclonal antibody CAT-152. Investigative Ophthalmology and Visual Science, 42. p. 2911. ISSN 1552-5783

Wormstone, I. Michael, Del Rio-Tsonis, Katia, McMahon, Gerald, Tamiya, Shigeo, Davies, Peter D., Marcantonio, Julia M. and Duncan, George (2001) FGF: An autocrine regulator of human lens cell growth independent of added stimuli. Investigative Ophthalmology & Visual Science, 42 (6). pp. 1305-1311. ISSN 0146-0404

Davidson, M. G., Wormstone, I. M., Morgan, D., Malakof, R., Allen, J. and McGahan, M. C. (2000) Ex vivo canine lens capsular sac explants. Graefe's Archive for Clinical and Experimental Ophthalmology, 238 (8). pp. 708-714. ISSN 0721-832X

Tamiya, Shigeo, Wormstone, I. Michael, Marcantonio, Julia M., Gavrilovic, Jelena and Duncan, George (2000) Induction of matrix metalloproteinases 2 and 9 following stress to the lens. Experimental Eye Research, 71 (6). pp. 591-597. ISSN 1096-0007

Wormstone, I. Michael, Tamiya, Shigeo, Marcantonio, Julia M. and Reddan, John R. (2000) Hepatocyte growth factor function and c-met expression in human lens epithelial cells. Investigative Ophthalmology and Visual Science, 41. pp. 4216-4222. ISSN 1552-5783

Duncan, G. and Wormstone, I. M. (1999) Calcium cell signalling and cataract: Role of the endoplasmic reticulum. Eye, 13 (3b). pp. 480-483. ISSN 0950-222X

Hightower, Kenneth R., Duncan, George, Dawson, Allan, Wormstone, I. Michael, Reddan, John and Dziedizc, Dorothy (1999) Research Note: Ultraviolet irradiation (UVB) interrupts calcium cell signaling in lens epithelial cells. Photochemistry and Photobiology, 69 (5). pp. 595-598. ISSN 0031-8655

Davidson, M. G., Harned, J., Grimes, A. M., Duncan, G., Wormstone, I. M. and McGahan, M. C. (1998) Transferrin in after-cataract and as a survival factor for lens epithelium. Experimental Eye Research, 66 (2). pp. 207-215. ISSN 1096-0007

Duncan, G., Wormstone, I. M., Liu, C. S. C., Marcantonio, J. M. and Davies, P. D. (1997) Thapsigargin-coated intraocular lenses inhibit human lens cell growth. Nature Medicine, 3 (9). pp. 1026-1028. ISSN 1078-8956

Duncan, George, Wormstone, I. Michael and Davies, Peter D. (1997) The aging human lens: structure, growth, and physiological behaviour. British Journal of Ophthalmology, 81 (10). pp. 818-823. ISSN 0007-1161

Quinlan, M, Wormstone, IM, Duncan, G and Davies, P D (1997) Phacoemulsification versus extracapsular cataract extraction: a comparative study of cell survival and growth on the human capsular bag in vitro. British Journal of Ophthalmology, 81 (10). pp. 907-910. ISSN 0007-1161

Book Section

Wormstone, Ian M., Eldred, Julie A. and Dawes, Lucy J. (2014) Fibrotic modifications of the lens epithelium. In: Lens Epithelium and Posterior Capsule Opacification. Springer, pp. 143-158. ISBN 978-4-431-54299-5

Wormstone, IM (2010) Posterior Capsule Opacification. In: Encyclopedia of the Eye. Academic Press, Oxford, pp. 469-475. ISBN 9780123742032

Duncan, G. and Wormstone, I.M. (2001) Physiology of the lens. In: Duane's Clinical Ophthalmology. UNSPECIFIED, pp. 1-20.