Fibrotic modifications of the lens epithelium

Wormstone, Ian M. ORCID:, Eldred, Julie A. and Dawes, Lucy J. (2014) Fibrotic modifications of the lens epithelium. In: Lens Epithelium and Posterior Capsule Opacification. Springer, pp. 143-158. ISBN 978-4-431-54299-5

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Maintaining lens integrity is a lifetime ambition of the lens. However, if this integrity is breached through an altered ocular environment or physical disruption, such as cataract surgery, then fibrotic modifications to the lens can occur that are ultimately detrimental to vision. Fibrotic changes involve hyperproliferation, transdifferentiation from an epithelial to a myofibroblast phenotype, matrix deposition and matrix contraction. Fibrotic conditions of the lens include anterior subcapsular cataract and posterior capsule opacification, which affect millions. In this chapter we will discuss the regulatory mechanisms that facilitate fibrotic events, which will involve the intimate relationship between growth factors (especially transforming growth factor beta—TGF-β), signal transduction pathways and the extracellular matrix.

Item Type: Book Section
Faculty \ School: Faculty of Science > School of Natural Sciences
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Cells and Tissues
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Depositing User: Pure Connector
Date Deposited: 11 May 2016 16:01
Last Modified: 27 Jan 2024 03:24

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