Items where Author is "Clark, Ian"

Article

Hayman, Dan J., Johnson de Sousa Brito, Francesca, Lin, Hua, Prior, Amanda, Charlesworth, Gemma, Hao, Yao, Pearson, Rachel D., Soul, Jamie, Clark, Ian M., Piróg, Katarzyna A., Barter, Matt J., van't Hof, Rob J. and Young, David A. (2025) microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity. Bone, 190. ISSN 8756-3282

Patel, Krutik, Barter, Matt, Soul, Jamie, Clark, Peter, Proctor, Carole, Clark, Ian, Young, David and Shanley, Daryl P. (2024) Systems analysis of miR-199a/b-5p and multiple miR-199a/b-5p targets during chondrogenesis. eLife, 12. ISSN 2050-084X

Lazar, A. S., Michalak, A., Shabana, Z., Mann, A., Vite, T. G., Conway, T., Grove, V., Tsigarides, J. ORCID: https://orcid.org/0000-0001-9893-8002, Gill, N., Tang, J. ORCID: https://orcid.org/0000-0001-6305-6333, Mioshi, E., Wagner, A. ORCID: https://orcid.org/0000-0002-9101-3477, Renoult, L. ORCID: https://orcid.org/0000-0001-7861-0552, Lazar, Z. I., Clark, I., Minihane, A. -M. ORCID: https://orcid.org/0000-0001-9042-4226 and Hornberger, M. ORCID: https://orcid.org/0000-0002-2214-3788 (2022) Early sleep and circadian markers of alzheimer's disease:the impact of apoe- epsilon 4 on sleep-wake regulation, brain activity and cognition in humans. Journal of Sleep Research, 31 (S1). ISSN 0962-1105

Barter, Matt J., Butcher, Andrew, Wang, Hui, Tsompani, Dimitra, Galler, Martin, Rumsby, Ellen L., Culley, Kirsty L., Clark, Ian M. and Young, David A. (2022) HDAC6 regulates NF-κB signalling to control chondrocyte IL-1-induced MMP and inflammatory gene expression. Scientific Reports, 12. ISSN 2045-2322

Swingler, Tracey E., Niu, Lingzi, Pontifex, Matthew G. ORCID: https://orcid.org/0000-0003-2174-2313, Vauzour, David ORCID: https://orcid.org/0000-0001-5952-8756 and Clark, Ian M. (2022) The microRNA-455 null mouse has memory deficit and increased anxiety, targeting key genes involved in Alzheimer’s disease. International Journal of Molecular Sciences, 23 (1). ISSN 1661-6596

Patel, Krutik, Chandrasegaran, Sharmilla, Clark, Ian M., Proctor, Carole J., Young, David A. and Shanley, Daryl P. (2021) TimiRGeN: R/Bioconductor package for time series microRNA-mRNA integration and analysis. Bioinformatics, 37 (20). 3604–3609. ISSN 1367-4803

Hayman, Dan J., Modebadze, Tamara, Charlton, Sarah, Cheung, Kat, Soul, Jamie, Lin, Hua, Hao, Yao, Miles, Colin G., Tsompani, Dimitra, Jackson, Robert M., Briggs, Michael D., Piróg, Katarzyna A., Clark, Ian M., Barter, Matt J., Clowry, Gavin J., Lebeau, Fiona E. N. and Young, David A. (2021) Increased hippocampal excitability in miR-324-null mice. Scientific Reports, 11. ISSN 2045-2322

Le, Linh, Niu, Lingzi, Barter, Matthew J., Young, David A., Dalmay, Tamas ORCID: https://orcid.org/0000-0003-1492-5429, Clark, Ian M. and Swingler, Tracey E. (2020) The role of microRNA-3085 in chondrocyte function. Scientific Reports, 10. ISSN 2045-2322

Woods, Steven, Charlton, Sarah, Cheung, Kathleen, Hao, Yao, Soul, Jamie, Reynard, Louise N., Crowe, Natalie, Swingler, Tracey E., Skelton, Andrew J., Piróg, Katarzyna A., Miles, Colin G., Tsompani, Dimitra, Jackson, Robert M., Dalmay, Tamas ORCID: https://orcid.org/0000-0003-1492-5429, Clark, Ian M., Barter, Matt J. and Young, David A. (2020) microRNA-seq of cartilage reveals an over-abundance of miR-140-3p which contains functional isomiRs. RNA, 26 (11). pp. 1575-1588. ISSN 1355-8382

Yao, Yufeng, Hu, Changqing, Song, Qixue, Li, Yong, Da, Xingwen, Yu, Yubin, Li, Hui, Clark, Ian M, Chen, Qiuyun and Wang, Qing K (2020) ADAMTS16 activates latent TGF-β, accentuating fibrosis and dysfunction of the pressure-overloaded heart. Cardiovascular Research, 116 (5). 956–969. ISSN 0008-6363

Le, Linh, Ho, Phuong and Clark, Ian (2020) The scinderin gene (SCIN) is the direct target of miR3085-3p in chondrocytes. Archives of Biological Sciences, 72 (3). pp. 373-378. ISSN 0354-4664

Swingler, Tracey, Niu, Lingzi, Smith, Perry, Paddy, Paige, Le, Linh, Barter, Matthew, Young, David and Clark, Ian (2019) The function of microRNAs in cartilage and osteoarthritis. Clinical and Experimental Rheumatology, 37 (5). pp. 40-47. ISSN 0392-856X

Woods, Steven, Barter, Matt J., Elliott, Hannah R., McGillivray, Catherine M., Birch, Mark A., Clark, Ian M. and Young, David A. (2019) miR-324-5p is up regulated in end-stage osteoarthritis and regulates Indian Hedgehog signalling by differing mechanisms in human and mouse. Matrix Biology, 77. pp. 87-100. ISSN 0945-053X

Davidson, Rose K. ORCID: https://orcid.org/0000-0002-6624-4011, Green, Jonathan, Gardner, Sarah, Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370, Cassidy, Aedin and Clark, Ian M. (2018) Identifying chondroprotective diet-derived bioactives and investigating their synergism. Scientific Reports, 8. ISSN 2045-2322

Legrand, Catherine, Ahmed, Usman, Anwar, Attia, Rajpoot, Kashif, Pasha, Sabah, Lambert, Cecile, Davidson, Rosemary ORCID: https://orcid.org/0000-0002-6624-4011, Clark, Ian, Thornalley, Paul, Henrotin, Yves and Rabbani, Naila (2018) Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo. Arthritis Research & Therapy, 20. ISSN 1478-6354

O'Sullivan, S. M., Galvin, K., Heneghan, C., Davidson, R. ORCID: https://orcid.org/0000-0002-6624-4011, Clark, I. and Lucey, A. J. (2018) Does daily consumption of vitamin K1 from cruciferous vegetables reach the circulation and the knee joint? Proceedings of the Nutrition Society, 77 (OCE3). ISSN 0029-6651

Barter, Matthew, Gomez, Rodolfo, Hyatt, Sam, Cheung, Kat, Skelton, Andrew, Xu, Yaobo, Clark, Ian and Young, David (2017) Long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Development, 144 (24). pp. 4510-4521. ISSN 0950-1991

Davidson, Rose ORCID: https://orcid.org/0000-0002-6624-4011, Gardner, Sarah, Jupp, Orla, Bullough, Angela, Butters, Sue, Watts, Laura, Donell, Simon, Traka, Maria, Saha, Shikha, Mithen, Richard, Jeffers, Mandy, Clegg, Peter, Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370, Cassidy, Aedin and Clark, Ian (2017) Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint. Scientific Reports, 7. ISSN 2045-2322

Karkampouna, S., Kreulen, M., Obdeijn, M. C., Kloen, P., Dorjée, A. L., Rivellese, F., Chojnowski, A., Clark, I. and Kruithof-de Julio, Marianna (2016) Connective tissue degeneration: Mechanisms of palmar fascia degeneration (Dupuytren’s disease). Current Molecular Biology Reports, 2 (3). 133–140. ISSN 2198-6428

Davidson, Rosemary ORCID: https://orcid.org/0000-0002-6624-4011, Jupp, Orla, Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370, MacGregor, Alexander ORCID: https://orcid.org/0000-0003-2163-2325, Donell, Simon, Cassidy, Aedin and Clark, Ian (2016) Can sulforaphane prevent the onset or slow the progression of osteoarthritis? Nutrition Bulletin, 41 (2). pp. 175-179. ISSN 1471-9827

Le, Linh T. T., Swingler, Tracey E., Crowe, Natalie, Vincent, Tonia L., Barter, Matthew J., Donell, Simon T., Delany, Anne M., Dalmay, Tamas ORCID: https://orcid.org/0000-0003-1492-5429, Young, David A. and Clark, Ian M. (2016) The microRNA-29 family in cartilage homeostasis and osteoarthritis. Journal of Molecular Medicine, 94 (5). pp. 583-596. ISSN 1432-1440

Snelling, Sarah, Davidson, Rosemary ORCID: https://orcid.org/0000-0002-6624-4011, Swingler, Tracey, Le, Thi, Barter, Matthew, Culley, Kirsty, Price, Andrew, Carr, Andrew and Clark, Ian (2016) Dickkopf-3 is upregulated in osteoarthritis and has a chondroprotective role. Osteoarthritis and Cartilage, 24 (5). 883–891. ISSN 1063-4584

Crowe, Natalie, Swingler, Tracey, Le, Linh, Barter, Matt, Wheeler, Guy, Pais, Helio, Donell, Simon, Young, David, Dalmay, Tamas ORCID: https://orcid.org/0000-0003-1492-5429 and Clark, Ian (2016) Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA. Osteoarthritis and Cartilage, 24 (3). pp. 534-543. ISSN 1063-4584

Barter, Matt J., Tselepi, Maria, Gómez, Rodolfo, Woods, Steven, Hui, Wang, Smith, Graham R., Shanley, Daryl P., Clark, Ian M. and Young, David A. (2015) Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR-140-5p. Stem Cells, 33 (11). pp. 3266-3280. ISSN 1066-5099

Davidson, R.K. ORCID: https://orcid.org/0000-0002-6624-4011 and Clark, I.M. (2015) Dietary intervention for osteoarthritis: Clinical trials after the 'Bone and Joint Decade'. Nutrition Bulletin, 40 (3). pp. 203-210. ISSN 1471-9827

Green, Jonathan A., Hirst-Jones, Kimberley L., Davidson, Rose K., Jupp, Orla, Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370, Macgregor, Alexander J. ORCID: https://orcid.org/0000-0003-2163-2325, Donell, Simon T., Cassidy, Aedín and Clark, Ian M. (2014) The potential for dietary factors to prevent or treat osteoarthritis. Proceedings of the Nutrition Society, 73 (02). pp. 278-288. ISSN 0029-6651

Snelling, S., Rout, R., Davidson, R. ORCID: https://orcid.org/0000-0002-6624-4011, Clark, I., Carr, A., Hulley, P.A. and Price, A.J. (2014) A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis. Osteoarthritis and Cartilage, 22 (2). pp. 334-343. ISSN 1063-4584

Karkampouna, Sofia, Kruithof, Boudewijn P. T., Kloen, Peter, Obdeijn, Miryam C., van der Laan, Annelies M. A., Tanke, Hans J., Kemaladewi, Dwi U., Hoogaars, Willem M. H., 't Hoen, Peter A. C., Aartsma-Rus, Annemieke, Clark, Ian M., ten Dijke, Peter, Goumans, Marie-José and Kruithof-De Julio, Marianna (2014) Novel ex vivo culture method for the study of Dupuytren's disease: Effects of TGFβ Type 1 receptor modulation by antisense oligonucleotides. Molecular Therapy - Nucleic Acids, 3. ISSN 2162-2531

Soond, Surinder M., Smith, Paul G., Wahl, Lloyd, Swingler, Tracey E., Clark, Ian M., Hemmings, Andrew M. ORCID: https://orcid.org/0000-0003-3053-3134 and Chantry, Andrew (2013) Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1832 (12). pp. 2127-2135. ISSN 0925-4439

Davidson, Rose K. ORCID: https://orcid.org/0000-0002-6624-4011, Jupp, Orla, de Ferrars, Rachel, Kay, Colin D., Culley, Kirsty L, Norton, Rosemary, Driscoll, Clare, Vincent, Tonia L., Donell, Simon T., Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 and Clark, Ian M. (2013) Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Arthritis and Rheumatism, 65 (12). pp. 3130-3140. ISSN 0004-3591

Le, Linh T. T., Swingler, Tracey E. and Clark, Ian M. (2013) Review: The role of microRNAs in osteoarthritis and chondrogenesis. Arthritis & Rheumatism, 65 (8). pp. 1963-1974. ISSN 0004-3591

Culley, Kirsty L., Hui, Wang, Barter, Matt J., Davidson, Rose K. ORCID: https://orcid.org/0000-0002-6624-4011, Swingler, Tracey E., Destrument, Auriane P. M., Scott, Jenny L., Donell, Simon T., Fenwick, Steve, Rowan, Andrew D., Young, David A. and Clark, Ian M. (2013) Class I histone deacetylase inhibition modulates metalloproteinase expression and blocks cytokine-induced cartilage degradation. Arthritis & Rheumatism, 65 (7). pp. 1822-1830. ISSN 0004-3591

Radwan, Marta, Gavriilidis, Christos, Robinson, John H., Davidson, Rosemary ORCID: https://orcid.org/0000-0002-6624-4011, Clark, Ian M., Rowan, Andrew D. and Young, David A. (2013) Matrix metalloproteinase 13 expression in response to double-stranded RNA in human chondrocytes. Arthritis & Rheumatism, 65 (5). pp. 1290-1301. ISSN 0004-3591

Wilkinson, Janine M., Davidson, Rose K., Swingler, Tracey E., Jones, Eleanor R., Corps, Anthony N., Johnston, Phillip, Riley, Graham P. ORCID: https://orcid.org/0000-0001-5528-5611, Chojnowski, Adrian J. and Clark, Ian M. (2012) MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1822 (6). pp. 897-905. ISSN 0925-4439

Ollivere, B., Wimhurst, J. A., Clark, I. M. and Donell, S. M. (2012) Current concepts in osteolysis. Journal of Bone and Joint Surgery - British Volume, 94-B (1). pp. 10-15. ISSN 0301-620X

Swingler, Tracey E., Wheeler, Guy, Carmont, Virginia, Elliott, Hannah R., Barter, Matthew J., Abu-Elmagd, Muhammad, Donell, Simon T., Boot-Handford, Raymond P., Hajihosseini, Mohammad K., Munsterberg, Andrea ORCID: https://orcid.org/0000-0002-4577-4240, Dalmay, Tamas ORCID: https://orcid.org/0000-0003-1492-5429, Young, David A. and Clark, Ian M. (2012) The expression and function of microRNAs in chondrogenesis and osteoarthritis. Arthritis & Rheumatism, 64 (6). pp. 1909-1919. ISSN 1529-0131

Norton, R., Sexton, D. W., Clark, I. M., Wilson, A. M., Hughes, D. A. and O'Connell, M. A. ORCID: https://orcid.org/0000-0002-0267-0951 (2011) Immunomodulatory effects of 1, 25 (OH)2 D-3 in normal and transformed human lung epithelium. Anticancer Research, 31 (4). p. 1499. ISSN 0250-7005

Fields, Jerel, Gardner-Mercer, Jessica, Borgmann, Kathleen, Clark, Ian M. and Ghorpade, Anuja (2011) CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1. Journal of Neurochemistry, 118. pp. 93-104. ISSN 1471-4159

Norton, Rosemary, Sexton, D. W., Clark, I. M., Wilson, A. M., Hughes, D. A. and O'Connell, M. A. ORCID: https://orcid.org/0000-0002-0267-0951 (2011) Response of lung epithelial cells to inflammatory stimuli following exposure to the active form of vitamin D. Proceedings of the Nutrition Society, 70 (OCE3). ISSN 0029-6651

Williams, Frances M. K., Skinner, Jane, Spector, Tim D., Cassidy, Aedin, Clark, Ian M., Davidson, Rose M. ORCID: https://orcid.org/0000-0002-6624-4011 and MacGregor, Alex J. ORCID: https://orcid.org/0000-0003-2163-2325 (2010) Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action. BMC Musculoskeletal Disorders, 11. ISSN 1471-2474

Milner, Jennifer M., Patel, Amit, Davidson, Rose K. ORCID: https://orcid.org/0000-0002-6624-4011, Swingler, Tracey E., Desilets, Antoine, Young, David A., Kelso, Elizabeth B., Donell, Simon T., Cawston, Tim E., Clark, Ian M., Ferrell, William R., Plevin, Robin, Lockhart, John C., Leduc, Richard and Rowan, Andrew D. (2010) Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis. Arthritis & Rheumatism, 62 (4). pp. 1955-1966. ISSN 1529-0131

Scott, Jenny L., Gabrielides, Christos, Davidson, Rose K. ORCID: https://orcid.org/0000-0002-6624-4011, Swingler, Tracey E., Clark, Ian M., Wallis, Gillian A., Boot-Handford, Raymond P., Kirkwood, Tom B.L., Talyor, Robert W. and Young, David A. (2010) Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Annals of the Rheumatic Diseases, 69 (8). pp. 1502-1510. ISSN 0003-4967

Pais, Helio, Nicolas, Francisco Esteban, Soond, Surinder M., Swingler, Tracey E., Clark, Ian M., Chantry, Andrew, Moulton, Vincent ORCID: https://orcid.org/0000-0001-9371-6435 and Dalmay, Tamas ORCID: https://orcid.org/0000-0003-1492-5429 (2010) Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level. RNA, 16 (3). pp. 489-494. ISSN 1355-8382

Barter, Matt J., Pybus, Leon, Litherland, Gary J., Rowan, Andrew D., Clark, Ian M., Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Cawston, Tim E. and Young, David A. (2010) HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes. Matrix Biology, 29 (7). pp. 602-612. ISSN 1569-1802

Swingler, Tracey E., Kevorkian, Lara, Culley, Kirsty L., Illman, Sara A., Young, David A., Parker, Andrew E., Lohi, Jouko and Clark, Ian M. (2010) MMP28gene expression is regulated by Sp1 transcription factor acetylation. Biochemical Journal, 427 (3). pp. 391-400. ISSN 0264-6021

Surridge, Alison K, Rodgers, Ursula R, Swingler, Tracey E, Davidson, Rose K ORCID: https://orcid.org/0000-0002-6624-4011, Kevorkian, Lara, Norton, Rosemary, Waters, Jasmine G, Goldring, Mary B, Parker, Andrew E and Clark, Ian M (2009) Characterization and regulation of ADAMTS-16. Matrix Biology, 28 (7). pp. 416-424. ISSN 1569-1802

Swingler, Tracey E., Waters, Jasmine G., Davidson, Rosemary K. ORCID: https://orcid.org/0000-0002-6624-4011, Pennington, Caroline J., Puente, Xose S., Darrah, Clare, Cooper, Adele, Donell, Simon T., Guile, Geoffrey R., Wang, Wenjia and Clark, Ian M. (2009) Degradome expression profiling in human articular cartilage. Arthritis Research & Therapy, 11.

Rodgers, Ursula R., Kevorkian, Lara, Surridge, Alison K., Waters, Jasmine G., Swingler, Tracey E., Culley, Kirsty, Illman, Sara, Lohi, Jouko, Parker, Andrew E. and Clark, Ian M. (2009) Expression and function of matrix metalloproteinase (MMP)-28. Matrix Biology, 28 (5). pp. 263-272. ISSN 1569-1802

Zhang, Q., Hu, W., Litherland, G. J., Barter, M. J., Davidson, R. ORCID: https://orcid.org/0000-0002-6624-4011, Darrah, C., Donell, S. T., Clark, I. M., Cawston, T. E., Robinson, J. H., Rowan, A. D. and Young, D. A. (2008) Differential Toll-like receptor-dependent collagenase expression in chondrocytes. Annals of the Rheumatic Diseases, 67. pp. 1633-1641. ISSN 1468-2060

Clark, I. M., Macgregor, A. J. ORCID: https://orcid.org/0000-0003-2163-2325 and Donell, S. T. (2008) Editorial-The genetic association between asporin and osteoarthritis. The Knee, 15 (3). vii-viii. ISSN 0968-0160

Clark, Ian M., Swingler, Tracey E., Sampieri, Clara L. and Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 (2008) The regulation of matrix metalloproteinases and their inhibitors. International Journal of Biochemistry & Cell Biology, 40 (6-7). pp. 1362-1378. ISSN 1878-5875

Clark, I., MacGregor, A. ORCID: https://orcid.org/0000-0003-2163-2325 and Donell, S. T. (2008) The genetic association between asporin and osteoarthritis. The Knee, 15 (3). vii-viii. ISSN 1873-5800

Johnston, Phillip, Larson, Debbie, Clark, Ian M. and Chojnowski, Adrian J. (2008) Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease. Journal of Hand Surgery-American Volume, 33 (7). pp. 1160-1167.

Sampieri, Clara L., Nuttall, Robert K., Young, David A., Goldspink, Deborah, Clark, Ian M. and Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 (2008) Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes. Matrix Biology, 27 (2). pp. 128-138. ISSN 1569-1802

Johnston, Phillip, Chojnowski, Adrian J., Davidson, Rose K. ORCID: https://orcid.org/0000-0002-6624-4011, Riley, Graham P. ORCID: https://orcid.org/0000-0001-5528-5611, Donell, Simon T. and Clark, Ian M. (2007) A complete expression profile of matrix-degrading metalloproteinases in Dupuytren’s disease. The Journal of Hand Surgery, 32 (3). pp. 343-351.

Clark, I.M., Swingler, T.E. and Young, D.A. (2007) Acetylation in the regulation of MMP and TIMP gene expression. Frontiers in Bioscience, 12. pp. 528-535.

Davidson, R.K. ORCID: https://orcid.org/0000-0002-6624-4011, Waters, J.G., Kevorkian, L., Darrah, C., Cooper, A., Donell, S.T. and Clark, I.M. (2006) Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage. Arthritis Research and Therapy, 8.

Jones, Gavin C., Corps, Anthony N., Pennington, Caroline J., Clark, Ian M., Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Bradley, Michelle M., Hazleman, Brian L. and Riley, Graham P. ORCID: https://orcid.org/0000-0001-5528-5611 (2006) Expression profiling of metalloproteinases and tissue inhibitors of metalloproteinases in normal and degenerate human achilles tendon. Arthritis & Rheumatism, 54 (3). pp. 832-842. ISSN 0004-3591

Engers, Rainer, Springer, Erik, Kehren, Verena, Simic, Tatjana, Young, David A., Beier, Juliane, Klotz, Lars-O., Clark, Ian M., Sies, Helmut and Gabbert, Helmut E. (2006) Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signalling. FEBS Journal, 273 (20). pp. 4754-4769. ISSN 1742-4658

Milner, Jennifer M., Kevorkian, Lara, Young, David A., Jones, Debra, Wait, Robin, Donell, Simon T., Barksby, Emma, Patterson, Angela M., Middleton, Jim, Cravatt, Benjamin F., Clark, Ian M., Rowan, Andrew D. and Cawston, Timothy E. (2006) Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis. Arthritis Research & Therapy, 8 (1).

Tuddenham, Lee, Wheeler, Guy, Ntouniafousara, Sofia, Waters, Jasmine, Hajihosseini, Mohammad, Clark, Ian and Dalmay, Tamas ORCID: https://orcid.org/0000-0003-1492-5429 (2006) The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Letters, 580 (17). pp. 4214-4217. ISSN 1873-3468

Porter, Sarah, Clark, Ian M., Kevorkian, Lara and Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 (2005) The ADAMTS metalloproteinases. Biochemical Journal, 386 (1). pp. 15-27. ISSN 1470-8728

Young, David A., Billingham, Olivia, Sampieri, Clara L., Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 and Clark, Ian M. (2005) Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta 1 induced murine tissue inhibitor of metalloproteinases-1 gene expression. FEBS Journal, 272 (8). pp. 1912-1926. ISSN 1742-4658

Young, David A., Lakey, Rachel L., Pennington, Caroline J., Jones, Debra, Kevorkian, Lara, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Cawston, Timothy E. and Clark, Ian M. (2005) Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Research & Therapy, 7 (3). pp. 503-512. ISSN 1478-6354

Kevorkian, Lara, Young, David A., Darrah, Clare, Donell, Simon T., Shepstone, Lee, Porter, Sarah, Brockbank, Sarah M. V., Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Parker, Andrew E. and Clark, Ian M. (2004) Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis and Rheumatism, 50 (1). pp. 131-141. ISSN 0004-3591

Young, David A., Gavrilov, Svetlana, Pennington, Caroline J., Nuttall, Robert K., Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Kitsis, Richard N. and Clark, Ian M. (2004) Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes. Biochemical and Biophysical Research Communications, 322 (3). pp. 759-765. ISSN 1090-2104

Hall, Marie-Claire, Young, David A., Waters, Jasmine G., Rowan, Andrew D., Chantry, Andrew, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 and Clark, Ian M. (2003) The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. Journal of Biological Chemistry, 278 (12). pp. 10304-10313. ISSN 1083-351X

Clark, I.M., Young, D.A. and Edwards, D.R. ORCID: https://orcid.org/0000-0002-3292-2064 (2003) TIMP-1 enhancer sequence: real or bacterial. British Journal of Cancer, 89. ISSN 0007-0920

Clark, Ian M. and Parker, Andrew E. (2003) Metalloproteinases: their role in arthritis and potential as therapeutic targets. Expert Opinion in Therapeutic Targets, 7 (1). pp. 19-34.

Murphy, Gillian, Knäuper, Vera, Atkinson, Susan, Butler, George, English, William ORCID: https://orcid.org/0000-0003-3024-2441, Hutton, Mike, Stracke, Jan and Clark, Ian (2002) Matrix metalloproteinases in arthritic disease. Arthritis Research and Therapy, 4 (3).

Koshy, P. J. T., Lundy, C. J., Rowan, A. D., Porter, S., Edwards, D. R. ORCID: https://orcid.org/0000-0002-3292-2064, Hogan, A., Clark, I. M. and Cawston, T. E. (2002) The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: A time-course study using real-time quantitative reverse transcription–polymerase chain reaction. Arthritis and Rheumatism, 46 (4). pp. 961-967. ISSN 1529-0131

Hall, M.C., Young, D.A., Rowan, A.D., Edwards, D.R. ORCID: https://orcid.org/0000-0002-3292-2064 and Clark, I.M. (2002) Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors. Biotechniques, 33. pp. 1004-1008.

Price, Jo S., Waters, Jasmine G., Darrah, Clare, Pennington, Caroline, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Donell, Simon T. and Clark, Ian M. (2002) The role of chondrocyte senescence in osteoarthritis. Aging Cell, 1 (1). pp. 57-65. ISSN 1474-9726

Young, David A., Philllips, Blaine W., Lundy, Caroline, Nuttall, Robert K., Hogan, Aileen, Schultz, Gilbert A., Leco, Kevin J., Clark, Ian M. and Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 (2002) Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene. Biochemical Journal, 364 (1). pp. 89-99. ISSN 1470-8728

Harvey, P., Clark, Ian, Jaurand, M-C, Warn, R. and Edwards, Dylan ORCID: https://orcid.org/0000-0002-3292-2064 (2000) Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases. British Journal of Cancer, 83 (9). pp. 1147-1153. ISSN 0007-0920

Dean, Greg, Young, David A., Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 and Clark, Ian M. (2000) The human tissue inhibitor of metalloproteinases (TIMP)-1 gene contains repressive elements within the promoter and intron 1. Journal of Biological Chemistry, 275 (42). pp. 32664-32671. ISSN 0021-9258

Clark, Ian M., Rowan, Andrew D., Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Bech-Hansen, Torben, Mann, Derek A., Bahr, Matthias J. and Cawston, Timothy E. (1997) Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1. Biochemical Journal, 324 (2). pp. 611-617. ISSN 0264-6021

Book Section

Jupp, Orla, Pullinger, Michael, Marjoram, Tom, Lott, Martin, Chojnowski, Adrian J. and Clark, Ian M. (2016) Biomarkers of Postsurgical Outcome in Dupuytren Disease. In: Dupuytren Disease and Related Diseases - The Cutting Edge. Springer, pp. 55-61. ISBN 978-3-319-32197-4

Wilkinson, Janine M., Jones, Eleanor R., Riley, Graham P. ORCID: https://orcid.org/0000-0001-5528-5611, Chojnowski, Adrian J. and Clark, Ian M. (2012) The Expression of Collagen-Degrading Proteases Involved in Dupuytren’s Disease Fibroblast-Mediated Contraction. In: Dupuytren’s Disease and Related Hyperproliferative Disorders. UNSPECIFIED, pp. 143-149.

Norton, R., Sexton, D. W., Clark, I. M., Wilson, A. M., Hughes, D. A. and O'Connell, M. A. ORCID: https://orcid.org/0000-0002-0267-0951 (2010) Immunomodulatory effects of vitamin D in the respiratory epithelium. In: Immunology. UNSPECIFIED, p. 140.

Rodgers, Ursula R. and Clark, Ian M. (2010) Expression of Recombinant MMP-28 in Mammalian Cells. In: Matrix Metalloproteinase Protocols. Springer, pp. 55-65. ISBN 978-1-4939-5622-7

Clark, I.M. and Murphy, G. (2004) Matrix proteinases. In: Dynamics of Bone and Cartilage Metabolism. Academic Press.

Clark, Ian M., Thomas, Mark D. and de Vos, Sarah (2002) Plant matrixins. In: Handbook of Proteolytic Enzymes (Second Edition). Academic Press, pp. 570-572. ISBN 978-0-12-079611-3

Conference or Workshop Item

Williams, F., Davidson, R. ORCID: https://orcid.org/0000-0002-6624-4011, Skinner, J., Culley, K., Bao, Y. P. ORCID: https://orcid.org/0000-0002-6425-0370, Cassidy, A., Clark, I. and MacGregor, A. ORCID: https://orcid.org/0000-0003-2163-2325 (2009) Epidemiological and Molecular Evidence for the Chondroprotective Effect of Garlic in Osteoarthritis. In: Annual Meeting of the British Society of Rheumatology, 2009-04-28 - 2009-05-01.

Book

Clark, I. M., Rowan, A. D. and Young, D. A. (2010) Matrix metalloproteinase protocols 2nd Edition. Methods in Molecular Biology . Springer (Humana Press). ISBN 978-1-60327-298-8