Metalloproteinases: their role in arthritis and potential as therapeutic targets

Clark, Ian M. and Parker, Andrew E. (2003) Metalloproteinases: their role in arthritis and potential as therapeutic targets. Expert Opinion in Therapeutic Targets, 7 (1). pp. 19-34.

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Abstract

Irreversible degradation of articular cartilage is a major feature of the arthritides, and its prevention is a therapeutic goal which has been difficult to achieve. Enzymes from the matrix metalloproteinase and ADAMTS (a disintegrin, a metalloproteinase, and thrombospondin motif) families are key mediators of cartilage extracellular matrix destruction. Inhibition of metalloproteinase activity is therefore a conceptually attractive therapeutic strategy, although clinical efficacy has not yet been demonstrated. This review outlines the biology behind metalloproteinases as drug targets in the arthritides, and poses important questions for the future design of such therapies.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:36
Last Modified:	07 Mar 2023 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/405
DOI:	10.1517/14728222.7.1.19

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