Clark, Ian M. and Parker, Andrew E. (2003) Metalloproteinases: their role in arthritis and potential as therapeutic targets. Expert Opinion in Therapeutic Targets, 7 (1). pp. 19-34.
Full text not available from this repository. (Request a copy)Abstract
Irreversible degradation of articular cartilage is a major feature of the arthritides, and its prevention is a therapeutic goal which has been difficult to achieve. Enzymes from the matrix metalloproteinase and ADAMTS (a disintegrin, a metalloproteinase, and thrombospondin motif) families are key mediators of cartilage extracellular matrix destruction. Inhibition of metalloproteinase activity is therefore a conceptually attractive therapeutic strategy, although clinical efficacy has not yet been demonstrated. This review outlines the biology behind metalloproteinases as drug targets in the arthritides, and poses important questions for the future design of such therapies.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Biological Sciences |
UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine |
Depositing User: | EPrints Services |
Date Deposited: | 01 Oct 2010 13:36 |
Last Modified: | 23 Jul 2024 15:34 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/405 |
DOI: | 10.1517/14728222.7.1.19 |
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