Biomarkers of Postsurgical Outcome in Dupuytren Disease

Jupp, Orla, Pullinger, Michael, Marjoram, Tom, Lott, Martin, Chojnowski, Adrian J. and Clark, Ian M. (2016) Biomarkers of Postsurgical Outcome in Dupuytren Disease. In: Dupuytren Disease and Related Diseases - The Cutting Edge. Springer, pp. 55-61. ISBN 978-3-319-32197-4

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We hypothesised that the measurement of circulating collagen-degrading matrix metalloproteinases (MMPs) would be predictive of postsurgical outcome after fasciectomy for Dupuytren disease (DD), measured through total extension deficit (TED). Assay of MMP-1, MMP-13 and MMP-14 in the plasma of DD patients showed poor correlation with change in TED after surgery. However, MMP-14 levels correlated with preoperative TED. In order to extend this study, we also measured the transcriptome in tissue samples from DD patients and showed that expression of specific genes correlated with preoperative and postoperative TED. These methodologies demonstrate the use of the approach in uncovering biomarkers which both illuminate the mechanism of the disease and have clinical utility.

Item Type: Book Section
Uncontrolled Keywords: gene expression,qrt-pcr,elisa,microarray,biomarker,recurrence
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
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Depositing User: Pure Connector
Date Deposited: 23 Sep 2016 16:00
Last Modified: 22 Jul 2021 23:39
DOI: 10.1007/978-3-319-32199-8_7

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