A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis

Snelling, S., Rout, R., Davidson, R., Clark, I., Carr, A., Hulley, P.A. and Price, A.J. (2014) A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis. Osteoarthritis and Cartilage, 22 (2). pp. 334-343. ISSN 1063-4584

Full text not available from this repository. (Request a copy)

Abstract

Objective: To identify osteoarthritis (OA) relevant genes and pathways in damaged and undamaged cartilage isolated from the knees of patients with anteromedial gonarthrosis (AMG) - a specific form of knee OA. Design: Cartilage was obtained from nine patients undergoing unicompartmental knee replacement (UKR) for AMG. AMG provides a spatial representation of OA progression; showing a reproducible and histologically validated pattern of cartilage destruction such that damaged and undamaged cartilage from within the same knee can be consistently isolated and examined. Gene expression was analysed by microarray and validated using real-time PCR. Results: Damaged and undamaged cartilage showed distinct gene expression profiles. 754 genes showed significant up- or down-regulation (non-False discovery rate (FDR) P

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: Pure Connector
Date Deposited: 11 Jun 2014 13:44
Last Modified: 05 May 2020 23:49
URI: https://ueaeprints.uea.ac.uk/id/eprint/48707
DOI: 10.1016/j.joca.2013.12.009

Actions (login required)

View Item View Item