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Snelling, S., Rout, R., Davidson, R. 
ORCID: https://orcid.org/0000-0002-6624-4011, Clark, I., Carr, A., Hulley, P.A. and Price, A.J.
(2014)
A gene expression study of normal and damaged cartilage in anteromedial gonarthrosis, a phenotype of osteoarthritis.
Osteoarthritis and Cartilage, 22 (2).
pp. 334-343.
ISSN 1063-4584
Abstract
Objective: To identify osteoarthritis (OA) relevant genes and pathways in damaged and undamaged cartilage isolated from the knees of patients with anteromedial gonarthrosis (AMG) - a specific form of knee OA. Design: Cartilage was obtained from nine patients undergoing unicompartmental knee replacement (UKR) for AMG. AMG provides a spatial representation of OA progression; showing a reproducible and histologically validated pattern of cartilage destruction such that damaged and undamaged cartilage from within the same knee can be consistently isolated and examined. Gene expression was analysed by microarray and validated using real-time PCR. Results: Damaged and undamaged cartilage showed distinct gene expression profiles. 754 genes showed significant up- or down-regulation (non-False discovery rate (FDR) P
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | Pure Connector |
| Date Deposited: | 11 Jun 2014 13:44 |
| Last Modified: | 25 Sep 2024 11:17 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/48707 |
| DOI: | 10.1016/j.joca.2013.12.009 |
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