Current concepts in osteolysis

Ollivere, B., Wimhurst, J. A., Clark, I. M. and Donell, S. M. (2012) Current concepts in osteolysis. Journal of Bone and Joint Surgery - British Volume, 94-B (1). pp. 10-15. ISSN 0301-620X

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The most frequent cause of failure after total hip replacement in all reported arthroplasty registries is peri-prosthetic osteolysis. Osteolysis is an active biological process initiated in response to wear debris. The eventual response to this process is the activation of macrophages and loss of bone. Activation of macrophages initiates a complex biological cascade resulting in the final common pathway of an increase in osteolytic activity. The biological initiators, mechanisms for and regulation of this process are beginning to be understood. This article explores current concepts in the causes of, and underlying biological mechanism resulting in peri-prosthetic osteolysis, reviewing the current basic science and clinical literature surrounding the topic.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Depositing User: Users 2731 not found.
Date Deposited: 17 Feb 2012 22:56
Last Modified: 25 Mar 2024 16:30
DOI: 10.1302/0301-620X.94B1.28047

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