Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

Davidson, Rose K. ORCID: https://orcid.org/0000-0002-6624-4011, Jupp, Orla, de Ferrars, Rachel, Kay, Colin D., Culley, Kirsty L, Norton, Rosemary, Driscoll, Clare, Vincent, Tonia L., Donell, Simon T., Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 and Clark, Ian M. (2013) Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Arthritis and Rheumatism, 65 (12). pp. 3130-3140. ISSN 0004-3591

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Abstract

Sulforaphane (SFN) has been reported to regulate signaling pathways relevant to chronic diseases. The aim of this study was to investigate the impact of SFN treatment on signaling pathways in chondrocytes and to determine whether sulforaphane could block cartilage destruction in osteoarthritis.

Item Type:	Article
Additional Information:	Funded by: Biotechnology and Biological Sciences Research Council (Diet and Health Research Industry Club). Grant Number: BB/I006060/1; Dunhill Medical Trust. Grant Number: R73/0208; Arthritis Research UK. Grant Number: 19371
Uncontrolled Keywords:	animals,arthritis, experimental,cartilage, articular,cattle,chondrocytes,humans,isothiocyanates,matrix metalloproteinases,mice,nf-e2-related factor 2,nf-kappa b,osteoarthritis,signal transduction
Faculty \ School:	Faculty of Science > School of Biological Sciences Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Environmental Sciences
Depositing User:	Pure Connector
Date Deposited:	12 Mar 2014 13:00
Last Modified:	31 Oct 2022 16:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/47553
DOI:	10.1002/art.38133

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