Tools
Tools
Davidson, Rose K. 
ORCID: https://orcid.org/0000-0002-6624-4011, Jupp, Orla, de Ferrars, Rachel, Kay, Colin D., Culley, Kirsty L, Norton, Rosemary, Driscoll, Clare, Vincent, Tonia L., Donell, Simon T., Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 and Clark, Ian M.
(2013)
Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo.
Arthritis and Rheumatism, 65 (12).
pp. 3130-3140.
ISSN 0004-3591
Preview |
PDF (Davidson_etal_2013_AandR)
- Published Version
Download (835kB) | Preview |
Abstract
Sulforaphane (SFN) has been reported to regulate signaling pathways relevant to chronic diseases. The aim of this study was to investigate the impact of SFN treatment on signaling pathways in chondrocytes and to determine whether sulforaphane could block cartilage destruction in osteoarthritis.
| Item Type: | Article |
|---|---|
| Additional Information: | Funded by: Biotechnology and Biological Sciences Research Council (Diet and Health Research Industry Club). Grant Number: BB/I006060/1; Dunhill Medical Trust. Grant Number: R73/0208; Arthritis Research UK. Grant Number: 19371 |
| Uncontrolled Keywords: | animals,arthritis, experimental,cartilage, articular,cattle,chondrocytes,humans,isothiocyanates,matrix metalloproteinases,mice,nf-e2-related factor 2,nf-kappa b,osteoarthritis,signal transduction |
| Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Environmental Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 12 Mar 2014 13:00 |
| Last Modified: | 28 Oct 2024 00:38 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/47553 |
| DOI: | 10.1002/art.38133 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |