Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo

Davidson, Rose K. ORCID: https://orcid.org/0000-0002-6624-4011, Jupp, Orla, de Ferrars, Rachel, Kay, Colin D., Culley, Kirsty L, Norton, Rosemary, Driscoll, Clare, Vincent, Tonia L., Donell, Simon T., Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 and Clark, Ian M. (2013) Sulforaphane represses matrix-degrading proteases and protects cartilage from destruction in vitro and in vivo. Arthritis and Rheumatism, 65 (12). pp. 3130-3140. ISSN 0004-3591

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Abstract

Sulforaphane (SFN) has been reported to regulate signaling pathways relevant to chronic diseases. The aim of this study was to investigate the impact of SFN treatment on signaling pathways in chondrocytes and to determine whether sulforaphane could block cartilage destruction in osteoarthritis.

Item Type: Article
Additional Information: Funded by: Biotechnology and Biological Sciences Research Council (Diet and Health Research Industry Club). Grant Number: BB/I006060/1; Dunhill Medical Trust. Grant Number: R73/0208; Arthritis Research UK. Grant Number: 19371
Uncontrolled Keywords: animals,arthritis, experimental,cartilage, articular,cattle,chondrocytes,humans,isothiocyanates,matrix metalloproteinases,mice,nf-e2-related factor 2,nf-kappa b,osteoarthritis,signal transduction
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Environmental Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User: Pure Connector
Date Deposited: 12 Mar 2014 13:00
Last Modified: 13 Nov 2023 16:58
URI: https://ueaeprints.uea.ac.uk/id/eprint/47553
DOI: 10.1002/art.38133

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