Connective tissue degeneration: Mechanisms of palmar fascia degeneration (Dupuytren’s disease)

Karkampouna, S., Kreulen, M., Obdeijn, M. C., Kloen, P., Dorjée, A. L., Rivellese, F., Chojnowski, A., Clark, I. and Kruithof-de Julio, Marianna (2016) Connective tissue degeneration: Mechanisms of palmar fascia degeneration (Dupuytren’s disease). Current Molecular Biology Reports, 2 (3). 133–140. ISSN 2198-6428

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Abstract

Dupuytren’s disease is a connective tissue disorder of the hand causing excessive palmar fascial fibrosis with associated finger contracture and disability. The aetiology of the disease is heterogeneous, with both genetic and environmental components. The connective tissue is abnormally infiltrated by myofibroblasts that deposit collagen and other extracellular matrix proteins. We describe the clinical profile of Dupuytren’s disease along with current therapeutic schemes. Recent findings on molecular and cellular parameters that are dysregulated in Dupuytren’s disease, which may contribute to the onset of the disease, and the role of resident inflammation promoting fibrosis, are highlighted. We review recent literature focusing on non-myofibroblast cell types (stem cell-like cells), their pro-inflammatory and pro-fibrotic role that may account for abnormal wound healing response.

Item Type: Article
Additional Information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords: inflammation,dupuytren’s,fibrosis,regeneration,contracture
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 24 Sep 2016 00:07
Last Modified: 14 Sep 2020 23:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/59833
DOI: 10.1007/s40610-016-0045-3

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