Items where Research Group is "Pharmacology and Biological Chemistry

B

Bastow, Emma L., Bych, Katrine, Crack, Jason C., Le Brun, Nick E. and Balk, Janneke (2017) NBP35 interacts with DRE2 in the maturation of cytosolic iron-sulfur proteins in Arabidopsis thaliana. The Plant Journal, 89 (3). 590–600. ISSN 0960-7412

Beekman, Andrew Michael, O'Connell, Maria Anne and Howell, Lesley Ann (2017) Peptide-directed binding for the discovery of modulators of α-helix-mediated protein-protein interactions: Proof-of-concept studies with the apoptosis regulator Mcl-1. Angewandte Chemie-International Edition, 56 (35). 10446–10450. ISSN 1433-7851

Bertrand, Benoît, Fernandez-Cestau, Julio, Angulo, Jesus, Cominetti, Marco M. D., Waller, Zoe A. E., Searcey, Mark, O'Connell, Maria A. and Bochmann, Manfred (2017) Cytotoxicity of pyrazine-based cyclometalated (C^Npz^C)Au(III) carbene complexes: Impact of the nature of the ancillary ligand on the biological properties. Inorganic Chemistry, 56 (10). 5728–5740. ISSN 0020-1669

Bertrand, Benoît, Romanov, Alexander S, Brooks, Mark, Schmidt, Claudia, Ott, Ingo, O'Connell, Maria Anne and Bochmann, Manfred (2017) Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals. Dalton Transactions, 46. pp. 15875-15887. ISSN 1477-9226

Bradley, Justin M., Moore, Geoffrey R. and Le Brun, Nick E. (2017) Diversity of Fe2+ entry and oxidation in ferritins. Current Opinion in Chemical Biology, 37. 122–128. ISSN 1367-5931

Bradley, Justin M., Svistunenko, Dimitri A., Moore, Geoffrey R. and Le Brun, Nick E. (2017) Tyr25, Tyr58 and Trp133 of Escherichia coli bacterioferritin transfer electrons between iron in the central cavity and the ferroxidase centre. Metallomics, 9 (10). pp. 1421-1428. ISSN 1756-5901

Bulman Page, Philip C., Goodyear, Ross L., Horton, Alexandra E., Chan, Yohan, Karim, Rehana, O'Connell, Maria A., Hamilton, Christopher, Slawin, Alexandra M. Z., Buckley, Benjamin R. and Allin, Steven M. (2017) Formal total synthesis of (+)-C9-deoxyomuralide from l-leucine using a double sacrificial chirality transfer approach. The Journal of Organic Chemistry, 82 (23). 12209–12223. ISSN 0022-3263

C

Chenge, Jude T., Duyet, Le Van, Swami, Shalini, McLean, Kirsty J., Kavanagh, Madeline E., Coyne, Anthony G., Rigby, Stephen E. J., Cheesman, Myles R., Girvan, Hazel M., Levy, Colin W., Rupp, Bernd, von Kries, Jens P., Abell, Chris, Leys, David and Munro, Andrew W. (2017) Structural characterization and ligand/inhibitor identification provide functional insights into the Mycobacterium tuberculosis cytochrome P450 CYP126A1. Journal of Biological Chemistry, 292 (4). pp. 1310-1329. ISSN 0021-9258

Crack, Jason C. and Le Brun, Nick E. (2017) Iron–Sulfur Cluster-based Sensors. In: Gas Sensing in Cells. Metallobiology . RSC Publishing, pp. 136-178. ISBN 978-1-78262-895-8

Crack, Jason C., Thomson, Andrew J. and Le Brun, Nick E. (2017) Mass spectrometric identification of intermediates in the O2-driven [4Fe-4S] to [2Fe-2S] cluster conversion in FNR. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114 (6). E3215–E3223. ISSN 1091-6490

D

De Luca, Simone N., Ziko, Ilvana, Dhuna, Kshitija, Sominsky, Luba, Tolcos, Mary, Stokes, Leanne and Spencer, Sarah J. (2017) Neonatal overfeeding by small-litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline. Journal of Neuroendocrinology, 29 (11). ISSN 0953-8194

De Santis, Stefania, Galleggiante, Vanessa, Scandiffio, Letizia, Liso, Marina, Sommella, Eduardo, Sobolewski, Anastasia, Spilotro, Vito, Pinto, Aldo, Campiglia, Pietro, Serino, Grazia, Santino, Angelo, Notarnicola, Maria and Chieppa, Marcello (2017) Secretory leukoprotease inhibitor (Slpi) expression is required for educating murine dendritic cells inflammatory response following quercetin exposure. Nutrients, 9 (7). ISSN 2072-6643

Deacon, Oliver, Karsisiotis, Andreas Ioannis, Moreno-Chicano, Tadeo, Hough, Michael A., Macdonald, Colin, Blumenschein, Tharin M. A., Wilson, Michael T., Moore, Geoffrey R. and Worrall, Jonathan A. R. (2017) Heightened dynamics of the oxidized Y48H variant of human cytochrome c increases its peroxidatic activity. Biochemistry, 56 (46). 6111–6124. ISSN 0006-2960

Dodd, Erin L., Crack, Jason C., Thomson, Andrew J. and Le Brun, Nick E. (2017) Reactivity of iron-sulfur clusters with nitric oxide. In: Iron-Sulfur Clusters in Chemistry and Biology. De Gruyter, pp. 387-438. ISBN 978-3-11-048043-6

J

Jeffery, Victoria, Goldson, Andrew J., Dainty, Jack R., Chieppa, Marcello and Sobolewski, Anastasia (2017) IL-6 signaling regulates small intestinal crypt homeostasis. Journal of Immunology, 199 (1). pp. 304-311. ISSN 0022-1767

K

Karsisiotis, Andreas Ioannis, Deacon, Oliver M., Macdonald, Colin, Blumenschein, Tharin M. A., Moore, Geoffrey R. and Worrall, Jonathan A. R. (2017) Near-complete backbone resonance assignments of acid-denatured human cytochrome c in dimethylsulfoxide: a prelude to studying interactions with phospholipids. Biomolecular NMR Assignments, 11 (2). 165–168. ISSN 1874-2718

Kay, Kristine L., Zhou, Liang, Tenori, Leonardo, Bradley, Justin Michael, Singleton, Chloe, Kihlken, Margaret A., Ciofi-Baffoni, Simone and Le Brun, Nicolas (2017) Kinetic analysis of copper transfer from a chaperone to its target protein mediated by complex formation. Chemical Communications, 53 (8). pp. 1397-1400. ISSN 1359-7345

Kudhair, Bassam K., Hounslow, Andrea M., Rolfe, Matthew D., Crack, Jason C., Hunt, Debbie M., Buxton, Roger S., Smith, Laura J., Le Brun, Nick E., Williamson, Michael P. and Green, Jeffrey (2017) Structure of a Wbl protein and implications for NO sensing by M. tuberculosis. Nature Communications, 8. ISSN 2041-1723

L

Leggett, Richard, Thomas, Paul, Marín, Maria J., Gavrilovic, Jelena and Russell, David A. (2017) Imaging of compartmentalised intracellular nitric oxide, induced during bacterial phagocytosis, using a metalloprotein–gold nanoparticle conjugate. Analyst, 142 (21). pp. 4099-4105.

P

Pellicer Martinez, Maria, Bermejo Martinez, Ana, Crack, Jason, Holmes, John D., Svistunenko, Dimitri, Johnston, Andrew, Cheesman, Myles, Todd, Jonathan and Le Brun, Nick (2017) Sensing iron availability via the fragile [4Fe-4S] cluster of the bacterial transcriptional repressor RirA. Chemical Science, 8. pp. 8451-8463. ISSN 2041-6520

Penon, Oriol, Marín, María J., Russell, David A. and Pérez-García, Lluïsa (2017) Water soluble, multifunctional antibody-porphyrin gold nanoparticles for targeted photodynamic therapy. Journal of Colloid and Interface Science, 496. 100–110. ISSN 0021-9797

R

Reed, James, Stephenson, Michael J, Miettinen, Karel, Brouwer, Bastiaan, Leveau, Aymeric, Brett, Paul, Goss, Rebecca J M, Goossens, Alain, O'Connell, Maria A and Osbourn, Anne (2017) A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules. Metabolic Engineering, 42. 185–193. ISSN 1096-7176

S

Smith, Laura J., Bochkareva, Aleksandra, Rolfe, Matthew D., Hunt, Debbie M, Kahramanoglou, Christina, Braun, Yvonne, Rodgers, Angela, Blockley, Alix, Coade, Stephen, Lougheed, Kathryn EA, Hafneh, Nor Azian, Glenn, Sarah M, Crack, Jason C, Le Brun, Nick E, Saldanha, José W, Macarov, Vadim, Nobeli, Irene, Arnvig, Kristine, Mukamolova, Galina V, Buxton, Roger S and Green, Jeffrey (2017) Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence. Nucleic Acids Research, 45 (11). pp. 6600-6612. ISSN 0305-1048

Stokes, Leanne, Layhadi, Janice A., Bibic, Lucka, Dhuna, Kshitija and Fountain, Samuel J. (2017) P2X4 receptor function in the nervous system and current breakthroughs in pharmacology. Frontiers in Pharmacology, 8. ISSN 1663-9812

V

Volbeda, Anne, Dodd, Erin L., Darnault, Claudine, Crack, Jason C., Renoux, Oriane, Hutchings, Matthew I., Le Brun, Nick E. and Fontecilla-Camps, Juan C. (2017) Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding. Nature Communications, 8. ISSN 2041-1723

W

Warner, Emily F., Smith, Michael J., Zhang, Qingzhi, Raheem, K. Saki, O'Hagan, David, O'Connell, Maria A. and Kay, Colin D. (2017) Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells. Molecular Nutrition & Food Research, 61 (9). ISSN 1613-4125

Wilkinson, Shane M, Barron, Melissa L, O'Brien-Brown, James, Janssen, Bieneke, Stokes, Leanne, Werry, Eryn L., Chishty, Mansoor, Skarratt, Kristen K., Ong, Jennifer A., Hibbs, David E., Vugts, Danielle J., Fuller, Stephen, Windhorst, Albert D. and Kassiou, Michael (2017) Pharmacological evaluation of novel bioisosteres of an adamantanyl benzamide P2X7 receptor antagonist. ACS Chemical Neuroscience, 8 (11). 2374–2380. ISSN 1948-7193

Williams, Morwen, Green, Adam I, Fernandez-Cestau, Julio, Hughes, David L, O'Connell, Maria Anne, Searcey, Mark, Bertrand, Benoit and Bochmann, Manfred (2017) (C^Npz^C)AuIII complexes of acyclic carbene ligands: synthesis and anticancer properties. Dalton Transactions, 46 (39). 13397–13408. ISSN 1477-9226