Items where Author is "Robinson, Stephen"

Article

Benwell, Christopher J., Johnson, Robert T., Taylor, James A. G. E., Lambert, Jordi and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2024) A proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: Neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells. Communications Biology, 7. ISSN 2399-3642

Teng, Nancy M. Y., Kiu, Raymond, Evans, Rhiannon, Baker, David J., Zenner, Christian, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 and Hall, Lindsay J. ORCID: https://orcid.org/0000-0001-8938-5709 (2023) Allocoprobacillus halotolerans gen. nov., sp. nov and Coprobacter tertius sp. nov., isolated from human gut microbiota. International Journal of Systematic and Evolutionary Microbiology, 73 (7). ISSN 1466-5026

Kiu, Raymond, Shaw, Alexander G., Sim, Kathleen, Acuna-Gonzalez, Antia, Price, Christopher A., Bedwell, Harley, Dreger, Sally A., Fowler, Wesley J., Cornwell, Emma, Pickard, Derek, Belteki, Gusztav, Malsom, Jennifer, Phillips, Sarah, Young, Gregory R., Schofield, Zoe, Alcon-Giner, Cristina, Berrington, Janet E., Stewart, Christopher J., Dougan, Gordon, Clarke, Paul ORCID: https://orcid.org/0000-0001-6203-7632, Douce, Gillian, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Kroll, J. Simon and Hall, Lindsay J. ORCID: https://orcid.org/0000-0001-8938-5709 (2023) Particular genomic and virulence traits associated with preterm infant-derived toxigenic Clostridium perfringens strains. Nature Microbiology, 8 (6). pp. 1160-1175. ISSN 2058-5276

Benwell, Christopher J., Johnson, Robert T., Taylor, James A. G. E., Price, Christopher A. and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2022) Endothelial VEGFR coreceptors neuropilin-1 and neuropilin-2 are essential for tumor angiogenesis. Cancer Research Communications, 2 (12). 1626–1640. ISSN 2767-9764

Feng, Tzu-Yu, Azar, Francesca N., Dreger, Sally A., Rosean, Claire Buchta, McGinty, Mitchell T., Putelo, Audrey M., Kolli, Sree H., Carey, Maureen A., Greenfield, Stephanie, Fowler, Wesley J., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 and Rutkowski, Melanie R. (2022) Reciprocal interactions between the gut microbiome and mammary tissue mast cells promote metastatic dissemination of HR+ breast tumors. Cancer Immunology Research, 10 (11). 1309–1325. ISSN 2326-6074

McKee, Alastair M., Kirkup, Benjamin M., Madgwick, Matthew, Fowler, Wesley J., Price, Christopher A., Dreger, Sally A., Ansorge, Rebecca, Makin, Kate A., Caim, Shabhonam, Le Gall, Gwenaelle ORCID: https://orcid.org/0000-0002-1379-2196, Paveley, Jack, Leclaire, Charlotte, Dalby, Matthew J., Alcon-Giner, Cristina, Andrusaite, Anna, Feng, Tzu-Yu, Di Modica, Martina, Triulzi, Tiziana, Tagliabue, Elda, Milling, Simon W. F., Weilbaecher, Katherine N., Rutkowski, Melanie R., Korcsmaros, Tamas, Hall, Lindsay J. ORCID: https://orcid.org/0000-0001-8938-5709 and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2021) Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumor growth. iScience, 24 (9). ISSN 2589-0042

Benwell, Christopher J., Taylor, James A. G. E. and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2021) Endothelial neuropilin‐2 influences angiogenesis by regulating actin pattern development and α5‐integrin‐ p ‐FAK complex recruitment to assembling adhesion sites. The FASEB Journal, 35 (8). ISSN 0892-6638

Teng, Nancy, Price, Christopher, Mckee, Alastair, Hall, Lindsay ORCID: https://orcid.org/0000-0001-8938-5709 and Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588 (2021) Exploring the impact of gut microbiota and diet on breast cancer risk and progression. International Journal of Cancer, 149 (3). pp. 494-504. ISSN 0020-7136

Hall, Lindsay ORCID: https://orcid.org/0000-0001-8938-5709 and Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588 (2021) Bacterial strains augment cancer therapeutics. Nature Microbiology, 6 (3). pp. 275-276. ISSN 2058-5276

Wong, Ping-Pui, Munoz-Felix, Jose M, Hijazi, Maruan, Kim, Hyojin, Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588, De Luxan-Delgado, Beatriz, Rodiguez-Hernandez, Irene, Maiques, Oscar, Meng, Ya-Ming, Meng, Qiong, Bodrug, Natalia, Dukinfield, Matthew Scott, Reynolds, Louise E, Elia, George, Clear, Andrew, Harwood, Catherine, Wang, Yu, Campbell, James J, Singh, Rajinder, Zhang, Penglie, Schall, Thomas J, Matchett, Kylie P, Henderson, Neil, Szlosarek, Peter W, Dreger, Sally, Smith, Sally, Jones, Louise, Gribben, John G, Cutillas, Pedro R, Meier, Pascal, Sanz-Moreno, Victoria and Hodivala-Dilke, Kairbaan (2020) Cancer burden is controlled by mural cell-β3-integrin regulated crosstalk with tumor cells. Cell, 181 (6). 1346-1363.e21. ISSN 0092-8674

Alghamdi, Abdullah, Benwell, Christopher, Atkinson, Samuel, Lambert, Jordi, Johnson, Robert and Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588 (2020) NRP2 as an emerging angiogenic player; promoting endothelial cell adhesion and migration by regulating recycling of α5 integrin. Frontiers in Cell and Developmental Biology, 8. ISSN 2296-634X

Lambert, Jordi, Makin, Kate, Akbareian, Sophia, Johnson, Robert, Alghamdi, Abdullah, Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588 and Edwards, Dylan ORCID: https://orcid.org/0000-0002-3292-2064 (2020) ADAMTS-1 and Syndecan-4 intersect in the regulation of cell migration and angiogenesis. Journal of Cell Science, 133 (7). ISSN 0021-9533

McKee, Alastair M., Hall, Lindsay J. ORCID: https://orcid.org/0000-0001-8938-5709 and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2019) The microbiota, antibiotics and breast cancer. Breast Cancer Management, 8 (3). ISSN 1758-1923

Atkinson, Samuel J., Gontarczyk, Aleksander M., Alghamdi, Abdullah A. A., Ellison, Tim S., Johnson, Robert T., Fowler, Wesley J., Kirkup, Benjamin M., Silva, Bernardo C., Harry, Bronwen E., Schneider, Jochen G., Weilbaecher, Katherine N., Mogensen, Mette M., Bass, Mark D., Parsons, Maddy, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2018) The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration. EMBO Reports, 19 (6). ISSN 1469-221X

Abdul-Aziz, Amina M., Shafat, Manar S., Sun, Yu, Marlein, Christopher R., Piddock, Rachel E., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Zhou, Zhigang, Collins, Angela, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2018) HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia. Oncogene, 37. 2676–2686. ISSN 0950-9232

Hanson, Kimberley, Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588, Al-Yousuf, Karamallah, Hendry, Adam, Sexton, Darren, Sherwood, Victoria and Wheeler, Grant ORCID: https://orcid.org/0000-0002-4335-8577 (2018) The anti-rheumatic drug, leflunomide, synergizes with MEK inhibition to suppress melanoma growth. Oncotarget, 9. pp. 3815-3829. ISSN 1949-2553

Marlein, Christopher R., Zaitseva, Lyubov, Piddock, Rachel E., Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan ORCID: https://orcid.org/0000-0002-3292-2064, Shafat, Manar S., Zhou, Zhigang, Lawes, Matthew, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts. Blood, 130 (14). pp. 1649-1660. ISSN 0006-4971

Liu, Peng, Atkinson, Samuel J., Akbareian, Sophia, Zhou, Zhigang, Munsterberg, Andrea ORCID: https://orcid.org/0000-0002-4577-4240, Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588 and Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 (2017) Sulforaphane exerts anti-angiogenesis effects against hepatocellular carcinoma through inhibition of STAT3/HIF-1α/VEGF signalling. Scientific Reports, 7. ISSN 2045-2322

Piddock, R E, Loughran, N, Marlein, C R, Robinson, S D ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, D R ORCID: https://orcid.org/0000-0002-3292-2064, Yu, S, Pillinger, G E, Zhou, Z, Zaitseva, L, Auger, M J, Rushworth, S A and Bowles, K M ORCID: https://orcid.org/0000-0003-1334-4526 (2017) PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment. Blood Cancer Journal, 7 (3). ISSN 2044-5385

Shafat, Manar S., Oellerich, Thomas, Mohr, Sebastian, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Marlein, Christopher R., Piddock, Rachel E., Fenech, Matthew, Zaitseva, Lyubov, Abdul-Aziz, Amina, Turner, Jeremy, Watkins, Johnathan A., Lawes, Matthew, Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart A. (2017) Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment. Blood, 129 (10). pp. 1320-1332. ISSN 0006-4971

Su, Xinming, Esser, Alison K., Amend, Sarah R., Xiang, Jingyu, Ross, Michael H., Fox, Gregory C., Kobayashi, Takayuki, Steri, Veronica, Roomp, Kirsten, Fontana, Francesca, Hurchla, Michelle A., Knolhoff, Brett L., Meyer, Melissa A., Morgan, Elizabeth A., Tomasson, Julia C., Novack, Joshua S., Zou, Wei, Faccio, Roberta, Novack, Deborah V., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Teitelbaum, Steven L., DeNardo, David G., Schneider, Jochen G. and Weilbaecher, Katherine N. (2016) Antagonizing integrin β3 increases immunosuppression in cancer. Cancer Research, 76 (12). pp. 3484-3495. ISSN 0008-5472

Ellison, Tim S., Atkinson, Samuel J., Steri, Veronica, Kirkup, Benjamin M., Preedy, Michael E. J., Johnson, Robert T., Ruhrberg, Christiana, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Schneider, Jochen G., Weilbaecher, Katherine and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2015) Suppression of β3-integrin in mice triggers a neuropilin-1- dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Disease Models & Mechanisms, 8. pp. 1105-1119. ISSN 1754-8403

Decock, Julie, Hendrickx, Wouter, Thirkettle, Sally, Gutiérrez-Fernández, Ana, Robinson, Stephen D ORCID: https://orcid.org/0000-0002-6606-7588 and Edwards, Dylan R ORCID: https://orcid.org/0000-0002-3292-2064 (2015) Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice. Breast Cancer Research, 17 (1). ISSN 1465-542X

Kelwick, Richard, Wagstaff, Laura, Decock, Julie, Roghi, Christian, Cooley, Lindsay S., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Arnold, Hugh, Gavrilovic, Jelena ORCID: https://orcid.org/0000-0002-5312-1784, Jaworski, Diane M., Yamamoto, Kazuhiro, Nagase, Hideaki, Seubert, Bastian, Krüger, Achim and Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 (2015) Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15. International Journal of Cancer, 136 (4). E14–E26. ISSN 0020-7136

Tavora, B., Batista, S., Alexopoulou, A. N., Kostourou, V., Fernandez, I., Robinson, S. D. ORCID: https://orcid.org/0000-0002-6606-7588, Lees, D. M., Serrels, B. and Hodivala-Dilke, K. (2014) Generation of point-mutant FAK knockin mice. genesis, 52 (11). pp. 907-915. ISSN 1526-954X

Steri, Veronica, Ellison, Tim S, Gontarczyk, Aleksander Maksym, Weilbaecher, Katherine, Schneider, Jochen G, Edwards, Dylan ORCID: https://orcid.org/0000-0002-3292-2064, Fruttiger, Marcus, Hodivala-Dilke, Kairbaan M and Robinson, Stephen Douglas ORCID: https://orcid.org/0000-0002-6606-7588 (2014) Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice. Circulation Research, 114 (1). pp. 79-91. ISSN 0009-7330

Kostourou, Vassiliki, Lechertier, Tanguy, Reynolds, Louise E., Lees, Delphine M., Baker, Marianne, Jones, Dylan T., Tavora, Bernardo, Ramjuan, Antoine R., Birdsey, Graeme M., Robinson, Stephen R. ORCID: https://orcid.org/0000-0002-6606-7588, Parsons, Maddy, Randi, Anna M., Hart, Ian R. and Hodivala-Dilke, Kairbaan (2013) FAK-heterozygous mice display enhanced tumour angiogenesis. Nature Communications, 4. ISSN 2041-1723

Baker, Marianne, Reynolds, Louise E., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Lees, Delphine M., Parsons, Maddy, Elia, George and Hodivala-Dilke, Kairbaan M. (2013) Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth. PLoS One, 8 (5). ISSN 1932-6203

Jones, Dylan T, Lechertier, Tanguy, Reynolds, Louise E, Mitter, Richard, Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588, Kirn-Safran, Catherine B, Hodivala-Dilke, Kairbaan M and Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588 (2013) Endogenous ribosomal protein L29 (RPL29):a newly identified regulator of angiogenesis in mice. Disease Models & Mechanisms, 6 (1). pp. 115-24. ISSN 1754-8411

Baker, M, Reynolds, LE, Robinson, Stephen, Parsons, M, Lechertier, T, Elia, G, Ben-Yosef, T and Hodivala-Dilke, K (2013) Claudin-14 - A novel regulator of angiogenesis. PLoS ONE. ISSN 1932-6203 (In Press)

Baker, Marianne, Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588, Lechertier, Tanguy, Barber, Paul R, Tavora, Bernardo, D'Amico, Gabriela, Jones, Dylan T, Vojnovic, Boris and Hodivala-Dilke, Kairbaan (2012) Use of the mouse aortic ring assay to study angiogenesis. Nature Protocols, 7 (1). pp. 89-104.

Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 and Hodivala-Dilke, Kairbaan M. (2011) The role of β3-integrins in tumor angiogenesis: context is everything. Current Opinion in Cell Biology, 23 (5). pp. 630-637.

Tavora, Bernardo, Batista, Silvia, Reynolds, Louise E., Jadeja, Shalini, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Kostourou, Vassiliki, Hart, Ian, Fruttiger, Marcus, Parsons, Maddy and Hodivala-Dilke, Kairbaan M. (2010) Endothelial FAK is required for tumour angiogenesis. EMBO Molecular Medicine, 2 (12). pp. 516-528. ISSN 1757-4684

da Silva, Rita Graça, Tavora, Bernardo, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Reynolds, Louise E., Szekeres, Charles, Lamar, John, Batista, Sílvia, Kostourou, Vassiliki, Germain, Mitchel A., Reynolds, Andrew R., Jones, Dylan T., Watson, Alan R., Jones, Janet L., Harris, Adrian, Hart, Ian R., Iruela-Arispe, M. Luisa, DiPersio, C. Michael, Kreidberg, Jordon A. and Hodivala-Dilke, Kairbaan M. (2010) Endothelial α3β1-integrin represses pathological angiogenesis and sustains endothelial-VEGF. American Journal of Pathology, 177 (3). pp. 1534-1548. ISSN 1525-2191

Reynolds, Louise E., Watson, Alan R., Baker, Marianne, Jones, Tania A., D’Amico, Gabriela, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Joffre, Carine, Garrido-Urbani, Sarah, Rodriguez-Manzaneque, Juan CarloS, Martino-Echarri, Estefanía, Aurrand-Lions, Michel, Sheer, Denise, Dagna-Bricarelli, Franca, Nizetic, Dean, McCabe, Christopher J., Turnell, Andrew S., Kermorgant, Stephanie, Imhof, Beat A., Adams, Ralf, Fisher, Elizabeth M. C., Tybulewicz, Victor L. J., Hart, Ian R. and Hodivala-Dilke, Kairbaan M. (2010) Tumour angiogenesis is reduced in the Tc1 mouse model of Down’s syndrome. Nature, 465 (7299). pp. 813-817. ISSN 0028-0836

Worth, Daniel C., Hodivala-Dilke, Kairbaan, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, King, Samantha J., Morton, Penny E., Gertler, Frank B., Humphries, Martin J. and Parsons, Maddy (2010) Alpha v 3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. Journal of Cell Biology, 189 (2). pp. 369-383. ISSN 0021-9525

D'Amico, Gabriela, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Germain, Mitchel, Reynolds, Louise E., Thomas, Gareth J., Elia, George, Saunders, Garry, Fruttiger, Marcus, Tybulewicz, Victor, Mavria, Georgia and Hodivala-Dilke, Kairbaan M. (2010) Endothelial-Rac1 is not required for tumor angiogenesis unless αvβ3-integrin is absent. PLoS One, 5 (3). ISSN 1932-6203

Germain, Mitchel, De Arcangelis, Adèle, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Baker, Marianne, Tavora, Bernardo, D'Amico, Gabriela, Silva, Rita, Kostourou, Vassiliki, Reynolds, Louise E., Watson, Alan, Jones, J. Louise, Georges-Labouesse, Elisabeth and Hodivala-Dilke, Kairbaan (2010) Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis. The Journal of Pathology, 220 (3). pp. 370-381. ISSN 1096-9896

Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Reynolds, Louise E., Kostourou, Vassiliki, Reynolds, Andrew R., da Silva, Rita Graça, Tavora, Bernardo, Baker, Marianne, Marshall, John F. and Hodivala-Dilke, Kairbaan M. (2009) avβ3 Integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis. Journal of Biological Chemistry, 284 (49). pp. 33966-33981. ISSN 0021-9258

D'Amico, Gabriela, Jones, Dylan T., Nye, Emma, Sapienza, Karen, Ramjuan, Antoine R., Reynolds, Louise E., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Kostourou, Vassiliki, Martinez, Dolores, Aubyn, Deborah, Grose, Richard, Thomas, Gareth J., Spencer-Dene, Bradley, Zicha, Daniel, Davies, Derek, Tybulewicz, Victor and Hodivala-Dilke, Kairbaan M. (2009) Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development, 136 (23). pp. 4043-4053. ISSN 0950-1991

Reynolds, Andrew R., Hart, Ian R., Watson, Alan R., Welti, Jonathan C., Silva, Rita G., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Da Violante, Georges, Gourlaouen, Morgane, Salih, Mishal, Jones, Matt C., Jones, Dylan T., Saunders, Garry, Kostourou, Vassiliki, Perron-Sierra, Françoise, Norman, Jim C., Tucker, Gordon C. and Hodivala-Dilke, Kairbaan M. (2009) Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nature Medicine, 15 (4). pp. 392-400. ISSN 1078-8956

Reynolds, Louise E., Conti, Francesco J., Silva, Rita, Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Iyer, Vandana, Rudling, Rob, Cross, Barbara, Nye, Emma, Hart, Ian R., DiPersio, C. Michael and Hodivala-Dilke, Kairbaan M. (2008) α3β1 integrin–controlled Smad7 regulates reepithelialization during wound healing in mice. Journal of Clinical Investigation, 118 (3). pp. 965-974. ISSN 0021-9738

Book Section

Taylor, James A. G. E., Benwell, Christopher J. and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2022) Using Immortalized Endothelial Cells to Study the Roles of Adhesion Molecules in VEGF-Induced Signaling. In: VEGF Signaling: Methods and Protocols. Methods in Molecular Biology . Humana Press Inc, pp. 133-141. ISBN 978-1-0716-2216-2