Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice

Steri, Veronica, Ellison, Tim S, Gontarczyk, Aleksander Maksym, Weilbaecher, Katherine, Schneider, Jochen G, Edwards, Dylan, Fruttiger, Marcus, Hodivala-Dilke, Kairbaan M and Robinson, Stephen Douglas (2014) Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice. Circulation Research, 114 (1). pp. 79-91. ISSN 0009-7330

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Abstract

The dramatic upregulation of αvβ3-integrin that occurs in the vasculature during tumor growth has long suggested that the endothelial expression of this molecule is an ideal target for antiangiogenic therapy to treat cancer. This discovery led to the development of small-molecule inhibitors directed against αvβ3-integrin that are currently in clinical trials. In 2002, we reported that β3-integrin-knockout mice exhibit enhanced tumor growth and angiogenesis. However, as β3-integrin is expressed by a wide variety of cells, endothelial cell-specific contributions to tumor angiogenesis are muddied by the use of a global knockout of β3-integrin function.

Item Type: Article
Uncontrolled Keywords: animals,cell adhesion,cell line, tumor,cell proliferation,endothelial cells,endothelium, vascular,focal adhesion protein-tyrosine kinases,integrin alphavbeta3,lung,mice,mice, inbred c57bl,neoplasms, experimental,neovascularization, pathologic
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science
Depositing User: Pure Connector
Date Deposited: 26 Mar 2014 13:18
Last Modified: 21 Apr 2020 22:58
URI: https://ueaeprints.uea.ac.uk/id/eprint/48287
DOI: 10.1161/CIRCRESAHA.114.301591

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