Items where Author is "Hemmings, Andrew"

Published

Zhou, Rui, Liu, Ziqian, Wu, Tongtong, Pan, Xianwei, Li, Tongtong, Miao, Kaiting, Li, Yuru, Hu, Xiaohui, Wu, Haigang, Hemmings, Andrew M., Jiang, Beier, Zhang, Zhenzhen and Liu, Ning (2024) Machine learning-aided discovery of T790M-mutant EGFR inhibitor CDDO-Me effectively suppresses non-small cell lung cancer growth. Cell Communication and Signaling, 22. ISSN 1478-811X

Rigby, Jake M., Chantry, Andrew, Hemmings, Andrew M., Richards, Christopher J., Stephenson, G. Richard and Storr, Thomas E. (2024) An improved synthesis of 2,3-diamino-5,6-dichloropyrazine: A useful heterocyclic scaffold. Synthesis, 56 (23). pp. 3587-3592. ISSN 0039-7881

Dudey, Ashley P., Rigby, Jake M., Hughes, Gregory R., Stephenson, G. Richard, Storr, Thomas E., Chantry, Andrew and Hemmings, Andrew M. (2024) Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases. Journal of Enzyme Inhibition and Medicinal Chemistry, 39 (1). ISSN 1475-6366

Sharma, Yogesh, Hemmings, Andrew M., Deshmukh, Rupesh and Pareek, Ashwani (2024) Metalloid transporters in plants: Bridging the gap in molecular structure and physiological exaptation. Journal of Experimental Botany. ISSN 0022-0957

Whitfield, Hayley L., Faba Rodriguez, Raquel, Shipton, Megan L., Li, Arthur W. H., Riley, Andrew M., Potter, Barry V. L., Hemmings, Andrew M. and Brearley, Charles A. (2024) Crystal structure and enzymology of Solanum tuberosum inositol tris/tetrakisphosphate kinase 1 (StITPK1). Biochemistry, 63 (1). pp. 42-52. ISSN 0006-2960

Whitfield, Hayley L., He, Sining, Gu, Yinghong, Sprigg, Colleen, Kuo, Hui-Fen, Chiou, Tzyy-Jen, Riley, Andrew M., Potter, Barry V. L., Hemmings, Andrew M. and Brearley, Charles A. (2023) Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4. Biochemical Journal, 480 (6). 433–453. ISSN 0264-6021

Rix, Gregory D., Sprigg, Colleen, Whitfield, Hayley, Hemmings, Andrew M., Todd, Jonathan D. and Brearley, Charles A. (2022) Characterisation of a soil MINPP phytase with remarkable long-term stability and activity from Acinetobacter sp. PLoS One, 17 (8). ISSN 1932-6203

Acquistapace, Isabella, Thompson, Emma J., Kuhn, Imke, Bedford, Mike, Brearley, Charles and Hemmings, Andrew (2022) Insights to the structural basis for the stereospecificity of the Escherichia coli phytase, AppA. International Journal of Molecular Sciences, 23 (11). ISSN 1661-6596

Faba-Rodriguez, Raquel, Gu, Yinghong, Salmon, Melissa, Dionisio, Giuseppe, Brinch-Pedersen, Henrik A., Brearley, Charles A. and Hemmings, Andrew M. (2022) Structure of a cereal purple acid phytase provides new insights to phytate degradation in plants. Plant Communications, 3 (2). ISSN 2590-3462

Bradley, Justin M., Fair, Josh, Hemmings, Andrew M. and Le Brun, Nick E. (2021) Key carboxylate residues for iron transit through the prokaryotic ferritin SynFtn. Microbiology, 167 (11). ISSN 1350-0872

Hughes, Gregory R., Dudey, Ashley P., Hemmings, Andrew M. and Chantry, Andrew (2021) Frontiers in PROTACs. Drug Discovery Today, 26 (10). pp. 2377-2383. ISSN 1359-6446

Whitfield, Hayley, Hemmings, Andrew M., Mills, Stephen J., Baker, Kendall, White, Gaye, Rushworth, Stuart, Riley, Andrew M., Potter, Barry V. L. and Brearley, Charles A. (2021) Allosteric site on SHIP2 identified through fluorescent ligand screening and crystallography: a potential new target for intervention. Journal of Medicinal Chemistry, 64 (7). 3813–3826. ISSN 0022-2623

Acquistapace, Isabella M., Zietek, Monika A., Li, Arthur W. H., Salmon, Melissa, Kuhn, Imke, Bedford, Mike R., Brearley, Charles A. and Hemmings, Andrew M. (2020) Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced fit structural mechanism. The Journal of Biological Chemistry, 295 (51). pp. 17724-17737. ISSN 0021-9258

Bradley, Justin M., Svistunenko, Dimitri A., Wilson, Michael T., Hemmings, Andrew M., Moore, Geoffrey R. and Le Brun, Nick E (2020) Bacterial iron detoxification at the molecular level. The Journal of Biological Chemistry, 295 (51). pp. 17602-17623. ISSN 0021-9258

Whitfield, Hayley, White, Gaye, Sprigg, Colleen, Riley, Andrew M., Potter, Barry V. L., Hemmings, Andrew and Brearley, Charles (2020) An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels. Biochemical Journal, 477 (14). 2621–2638. ISSN 0264-6021

Bradley, Justin, Pullin, Jacob, Moore, Geoff, Svistunenko, Dimitri A., Hemmings, Andrew and Le Brun, Nick (2020) Routes of iron entry into, and exit from, the catalytic ferroxidase sites of the prokaryotic ferritin SynFtn. Dalton Transactions, 49 (5). pp. 1545-1554. ISSN 1477-9226

Bradley, Justin M., Svistunenko, Dimitri A., Pullin, Jacob, Hill, Natalie, Stuart, Rhona K., Palenik, Brian, Wilson, Michael T., Hemmings, Andrew M., Moore, Geoffrey R. and Le Brun, Nick E. (2019) Reaction of O2 with a di-iron protein generates a mixed valent Fe2+/Fe3+ center and peroxide. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 116 (6). pp. 2058-2067. ISSN 1091-6490

Louveau, Thomas, Orme, Anastasia, Pfalzgraf, Hans, Stephenson, Michael J., Melton, Rachel, Saalbach, Gerhard, Hemmings, Andrew M., Leveau, Aymeric, Rejzek, Martin, Vickerstaff, Robert, Langdon, Tim, Field, Robert and Osbourn, Anne (2018) Analysis of two new Arabinosyltransferases belonging to the carbohydrate-active enzyme (CAZY) Glycosyl Transferase Family1 provides insights into disease resistance and sugar donor specificity. Plant Cell, 30 (12). pp. 3038-3057. ISSN 1532-298X

Watt, Jessica, Hughes, Gregory, Walpole, Samuel, Monaco, Serena, Stephenson, G., Bulman Page, Philip, Hemmings, Andrew, Angulo, Jesus and Chantry, Andrew (2018) Discovery of small molecule WWP2 ubiquitin ligase inhibitors. Chemistry - A European Journal, 24 (67). pp. 17677-17680. ISSN 0947-6539

Whitfield, Hayley, Gilmartin, Megan, Baker, Kendall, Riley, Andrew M, Godage, Himali Y, Potter, Barry VL, Hemmings, Andrew M and Brearley, Charles A (2018) A Fluorescent Probe Identifies Active Site Ligands of Inositol Pentakisphosphate 2-Kinase. Journal of Medicinal Chemistry, 61 (19). 8838–8846. ISSN 0022-2623

Salmon, Melissa, Thimmappa, Ramesha B., Minto, Robert E., Melton, Rachel E., Hughes, Richard K., O'Maille, Paul E., Hemmings, Andrew M. and Osbourn, Anne (2016) A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 113 (30). E4407–E4414. ISSN 1091-6490

Bradley, Justin M., Svistunenko, Dimitri A., Lawson, Tamara L., Hemmings, Andrew M., Moore, Geoffrey R. and Le Brun, Nick E. (2015) Three aromatic residues are required for electron transfer during iron mineralization in Bacterioferritin. Angewandte Chemie-International Edition, 127 (49). 14976–14980. ISSN 1433-7851

Etzold, Sabrina, Mackenzie, Donald A., Jeffers, Faye, Walshaw, John, Roos, Stefan, Hemmings, Andrew M. and Juge, Nathalie (2014) Structural and molecular insights into novel surface-exposed mucus adhesins from Lactobacillus reuteri human strains:A novel mucus adhesin from Lactobacillus reuteri. Molecular Microbiology, 92 (3). pp. 543-556. ISSN 0950-382X

Etzold, Sabrina, Kober, Olivia I., Mackenzie, Donald A., Tailford, Louise E., Gunning, A. Patrick, Walshaw, John, Hemmings, Andrew M. and Juge, Nathalie (2014) Structural basis for adaptation of lactobacilli to gastrointestinal mucus. Environmental Microbiology, 16 (3). pp. 888-903. ISSN 1462-2912

Stentz, Régis, Osborne, Samantha, Horn, Nikki, Li, Arthur, Hautefort, Isabelle, Bongaerts, Roy, Rouyer, Marine, Bailey, Paul, Shears, Stephen B., Hemmings, Andrew, Brearley, Charles A. and Carding, Simon (2014) A bacterial homolog of a eukaryotic inositol phosphate signaling enzyme mediates cross-kingdom dialog in the mammalian gut. Cell Reports, 6 (4). pp. 646-656. ISSN 2211-1247

Soond, Surinder M., Smith, Paul G., Wahl, Lloyd, Swingler, Tracey E., Clark, Ian M., Hemmings, Andrew M. and Chantry, Andrew (2013) Novel WWP2 ubiquitin ligase isoforms as potential prognostic markers and molecular targets in cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1832 (12). pp. 2127-2135. ISSN 0925-4439

Geisler, Katrin, Hughes, Richard K., Sainsbury, Frank, Lomonossoff, George P., Rejzek, Martin, Fairhurst, Shirley, Olsen, Carl-Erik, Motawia, Mohammed Saddik, Melton, Rachel E., Hemmings, Andrew M., Bak, Søren and Osbourn, Anne (2013) Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 110 (35). E3360-E3367. ISSN 0027-8424

Holmes, Neil A., Walshaw, John, Leggett, Richard M., Thibessard, Annabelle, Dalton, Kate A., Gillespie, Michael D., Hemmings, Andrew M., Gust, Bertolt and Kelemen, Gabriella H. (2013) Coiled-coil protein Scy is a key component of a multiprotein assembly controlling polarized growth in Streptomyces. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 110 (5). pp. 397-406. ISSN 1091-6490

Bradley, Justin M., Marritt, Sophie J., Kihlken, Margaret A., Haynes, Kate, Hemmings, Andrew M., Berks, Ben C., Cheesman, Myles R. and Butt, Julea N. (2012) Redox and chemical activities of the hemes in the sulfur oxidation pathway enzyme SoxAX. Journal of Biological Chemistry, 287 (48). pp. 40350-40359. ISSN 0021-9258

Lockwood, Colin W. J., Clarke, Thomas A., Butt, Julea N., Hemmings, Andrew M. and Richardson, David J. (2011) Characterization of the active site and calcium binding in cytochromecnitrite reductases. Biochemical Society Transactions, 39 (6). pp. 1871-1875. ISSN 0300-5127

Kemp, Gemma L., Clarke, Thomas A., Marritt, Sophie J., Lockwood, Colin, Poock, Susannah R., Hemmings, Andrew M., Richardson, David J., Cheesman, Myles R. and Butt, Julea N. (2010) Kinetic and thermodynamic resolution of the interactions between sulfite and the pentahaem cytochrome NrfA from Escherichia coli. Biochemical Journal, 431 (1). pp. 73-80. ISSN 0264-6021

Hearnshaw, Stephen, West, Claire, Singleton, Chloe, Zhou, Liang, Kihlken, Margaret A., Strange, Richard W., Le Brun, Nick E. and Hemmings, Andrew M. (2009) A tetranuclear Cu(I) cluster in the metallochaperone protein CopZ. Biochemistry, 48 (40). pp. 9324-9326. ISSN 0006-2960

MacKenzie, Donald A., Tailford, Louise E., Hemmings, Andrew M. and Juge, Nathalie (2009) Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity. Journal of Biological Chemistry, 284 (47). pp. 32444-32453. ISSN 0021-9258

Singleton, Chloe, Hearnshaw, Stephen, Zhou, Liang, Le Brun, Nick E. and Hemmings, Andrew M. (2009) Mechanistic insights into Cu(I) cluster transfer between the chaperone CopZ and its cognate Cu(I)-transporting P-type ATPase, CopA. Biochemical Journal, 424 (3). pp. 347-356. ISSN 0264-6021

Caddick, Samuel E. K., Harrison, Christopher J., Stavridou, Ioanna, Mitchell, Jennifer L., Hemmings, Andrew M. and Brearley, Charles A. (2008) Solanum tuberosum inositol phosphate kinase (StlTPK1) displaying inositol phosphate-inositol phosphate and inositol phosphate-ADP phosphotransferase activities. FEBS Letters, 582 (12). pp. 1731-1737. ISSN 1873-3468

Clarke, Thomas A., Kemp, Gemma L., Van Wonderen, Jessica H., Doyle, Rosie-Marie A. S., Cole, Jeffrey A., Tovell, Nick, Cheesman, Myles R., Butt, Julea N., Richardson, David J. and Hemmings, Andrew M. (2008) Role of a conserved gluatmine residue in tuning the catalytic activity of Escherichia coli cytochrome c nitrite reductase. Biochemistry, 47 (12). pp. 3789-3799.

Clarke, Thomas A., Mills, Paul C., Poock, Susie R., Butt, Julea N., Cheesman, Myles R., Cole, Jeffrey A., Hinton, Jay C. D., Hemmings, Andrew M., Kemp, Gemma, Söderberg, Christopher A. G., Spiro, Stephen, van Wonderen, Jessica and Richardson, David J. (2008) Escherichia coli cytochrome c nitrite reductase NrfA. Methods in Enzymology, 437. pp. 63-77. ISSN 1557-7988

Clarke, Thomas A., Cole, Jeffrey A., Richardson, David J. and Hemmings, Andrew M. (2007) The crystal structure of the pentahaem c-type cytochrome NrfB and characterization of its solution-state interaction with the pentahaem nitrite reductase NrfA. Biochemical Journal, 406 (1). pp. 19-30. ISSN 1470-8728

Jepson, Brian J. N., Mohan, Sudesh, Clarke, Thomas A., Gates, Andrew J., Cole, Jeffrey A., Butler, Clive S., Butt, Julea N., Hemmings, Andrew M. and Richardson, David J. (2007) Spectropotentiometric and structural analysis of the periplasmic nitrate reductase from Escherichia coli. Journal of Biological Chemistry, 282 (9). pp. 6425-6437. ISSN 1083-351X

Sauvé, Véronique, Bruno, Stefano, Berks, Ben C. and Hemmings, Andrew M. (2007) The SoxYZ complex carries sulfur cycle intermediates on a peptide swinging arm. Journal of Biological Chemistry, 282. pp. 23194-23204. ISSN 1083-351X

Zhu, Daan, Razaz, M. and Hemmings, A. (2006) MLEM deconvolution of protein X-ray diffraction images based on a multiple-PSF model. IEEE Transactions on Nanobioscience, 5 (2). pp. 95-102. ISSN 1536-1241

Bellini, Pierdomenico and Hemmings, Andrew M. (2006) In vitro characterization of a bacterial manganese uptake regulator of the Fur superfamily. Biochemistry, 45 (8). pp. 2686-2698. ISSN 0006-2698

Clarke, TA, Hemmings, AM, Burlat, B, Butt, JN, Cole, JA and Richardson, DJ (2006) Comparison of the structural and kinetic properties of the cytochrome c nitrite reductases from Escherichia coli, Wolinella succinogenes, Sulfurospirillum deleyianum and Desulfovibrio desulfuricans. Biochemical Society Transactions, 34 (1). pp. 143-145. ISSN 1470-8752

Kolade, Olatomirin O., Bamford, Vicki A., Anton, Gema Ancillo, Jones, Jonathan D. G., Vera, Pablo and Hemmings, Andrew M. (2006) In vitro characterization of the cysteine-rich capping domains in a plant leucine rich repeat protein. Biochimica et Biophysica Acta - Proteins and Proteomics, 1764 (6). pp. 1043-1053.

Qi, Xiaoquan, Bakht, Saleha, Qin, Bo, Leggett, Mike, Hemmings, Andrew, Mellon, Fred, Eagles, John, Werck-Reichhart, Daniele, Schaller, Hubert, Lesot, Agnes, Melton, Rachel and Osbourn, Anne (2006) A different function for a member of an ancient and highly conserved cytochrome P450 family: From essential sterols to plant defense. Proceedings of the National Academy of Sciences USA, 103 (49). pp. 18848-18853. ISSN 1091-6490

Wilkinson, Adam, Smith, Andrew, Bullard, Desmond, Lavesa-Curto, Manuel, Sayer, Heather, Bonner, Alexandra, Hemmings, Andrew and Bowater, Richard (2005) Analysis of ligation and DNA binding by Escherichia coli DNA ligase (LigA). Biochimica et Biophysica Acta - Proteins and Proteomics, 1749 (1). pp. 113-122. ISSN 1570-9639

Burlat, B., Gwyer, J. D., Poock, S., Clarke, T. A., Cole, J. A., Hemmings, A. M., Cheesman, M. R., Butt, J. N. and Richardson, D. J. (2005) Cytochrome c nitrite reductase: from structural to physicochemical analysis. Biochemical Society Transactions, 33 (1). pp. 137-140. ISSN 1470-8752

Fanutti, C, Coussons, PJ and Hemmings, AM (2005) Helical peptide found in the channel of the outer membrance protein TolC. In: Biosciences Meeting, Glasgow, The Biochemical Society, 2005-01-01.

Lavesa-Curto, Manuel, Sayer, Heather, Bullard, Desmond, MacDonald, Andrew, Wilkinson, Adam, Smith, Andrew, Bowater, Laura, Hemmings, Andrew and Bowater, Richard P. (2004) Characterization of a temperature-sensitive DNA ligase from Escherichia coli. Microbiology, 150. pp. 4171-4180. ISSN 1465-2080

Clarke, Thomas A., Dennison, Victoria, Seward, Harriet E., Burlat, Bénédicte, Cole, Jeffrey A., Hemmings, Andrew M. and Richardson, David J. (2004) Purification and spectropotentiometric characterization of Escherichia coli NrfB, a decaheme homodimer that transfers electrons to the decaheme periplasmic nitrite reductase complex. Journal of Biological Chemistry, 279 (40). pp. 41333-41339. ISSN 0021-9258

Bamford, Vicki A., Kolade, Ola O., Osbourn, Anne E. and Hemmings, Andrew M. (2004) Purification, crystallization and preliminary X-ray diffraction analysis of a fungal saponin-detoxifying enzyme. Acta Crystallographica D, 60. pp. 1331-1333.

Zhu, D., Razaz, M., Hemmings, A. and Wang, B. (2004) Multiple point spread function modeling for deconvolution of 3D X-ray diffraction data. Journal of X-Ray Science & Technology, 12. pp. 179-194. ISSN 1095-9114

Zhu, Daan, Razaz, Moe, Hemmings, Andrew and Wang, Binhai (2004) Multi-PSF modelling for X-ray diffraction pattern reconstruction. In: 12th European Signal Processing Conference, 2004-09-06 - 2004-09-10.

Wexler, M., Todd, J.D., Kolade, O., Bellini, D., Hemmings, A.M., Sawers, G. and Johnston, A.W.B. (2003) Fur is not the global regulator of iron uptake genes in Rhizobium leguminosarum. Microbiology, 149. pp. 1357-1365. ISSN 1465-2080

Bamford, Vicki A., Angove, Hayley C., Seward, Harriet E., Thomson, Andrew J., Cole, Jeffrey A., Butt, Julea N., Hemmings, Andrew M. and Richardson, David J. (2002) Structure and spectroscopy of the periplasmic cytochrome c nitrite reductase from Escherichia coli. Biochemistry, 41 (9). pp. 2921-2931.

Bamford, V.A., Berks, B.C. and Hemmings, A.M. (2002) Novel domain packing in the crystal structure of a thiosulphate-oxidizing enzyme. Biochemical Society Transactions, 30. pp. 638-642. ISSN 1470-8752

Bamford, Vicki A., Bruno, Stefano, Rasmussen, Tim, Appia-Ayme, Corinne, Cheesman, Myles R., Berks, Ben C. and Hemmings, Andrew M. (2002) Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme. The EMBO Journal, 21. pp. 5599-5610. ISSN 1460-2075

Collins, Emily S., Whittaker, Sara B.-M., Tozawa, Kaeko, MacDonald, Colin J., Boetzel, Ruth, Penfold, Christopher N., Reilly, Ann, Clayden, Nigel J., Osborne, Michael J., Hemmings, Andrew M., Kleanthous, Colin, James, Richard and Moore, Geoffrey R. (2002) Structural dynamics of the membrane translocation domain of colicin E9 and its interaction with TolB. Journal of Molecular Biology, 318. pp. 787-804. ISSN 1089-8638

Keeble, Anthony H., Hemmings, Andrew M., James, Richard, Moore, Geoffrey R. and Kleanthous, Colin (2002) Multistep binding of transition metals to the H-N-H endonuclease toxin colicin E9. Biochemistry, 41. pp. 10234-10244.

Kolade, O. O., Bellini, P., Wexler, M., Johnston, A. W. B., Grossmann, J. G. and Hemmings, A. M. (2002) Structural studies of the Fur protein from Rhizobium leguminosarum. Biochemical Society Transactions, 30 (4). pp. 771-774. ISSN 1470-8752

Kolade, Olatomirin O., Carr, Stephen B., Kühlmann, Ulrike C., Pommer, Ansgar, Kleanthous, Colin, Bouchcinsky, Cristina A. and Hemmings, Andrew M. (2002) Structural aspects of the inhibition of Dnase and rRNase colicins by their immunity proteins. Biochimie, 84 (5-6). pp. 439-446. ISSN 1638-6183

Pommer, Ansgar J., Cal, Santiago, Keeble, Anthony H., Walker, Daniel, Evans, Steven J., Kuhlmann, Ulrike C., Cooper, Alan, Connolly, Bernard A., Hemmings, Andrew, Moore, Geoff, James, Richard and Kleanthous, Colin (2001) Mechanism and cleavage specificity of the H-N-H endonuclease colicin E9. Journal of Molecular Biology, 314 (4). pp. 735-749. ISSN 1089-8638

Penfold, Christopher N., Garinot-Schneider, Carole, Hemmings, Andrew M., Moore, Geoffrey R., Kleanthous, Colin and James, Richard (2000) A 76-residue polypeptide of colicin E9 confers receptor specificity and inhibits the growth of vitamin B12-dependent Escherichia coli 113/3 cells. Molecular Microbiology, 38 (3). pp. 639-649. ISSN 0950-382X

Carr, Stephen, Walker, Daniel, James, Richard, Kleanthous, Colin and Hemmings, Andrew M. (2000) Inhibition of a ribosome-inactivating ribonuclease:The crystal structure of the cytotoxic domain of colicin E3 in complex with its immunity protein. Structure, 8 (9). pp. 949-960. ISSN 0969-2126

Hannan, Jonathan P., Whittaker, Sara B.-M., Hemmings, Andrew M., James, Richard, Kleanthous, Colin and Moore, Geoffrey R. (2000) NMR studies of metal ion binding to the Zn-finger-like HNH motif of colicin E9. Journal of Inorganic Biochemistry, 79 (1-4). pp. 365-370. ISSN 0162-0134

Carr, Stephen, Penfold, Christopher N., Bamford, Vicki, James, Richard and Hemmings, Andrew M. (2000) The structure of TolB, an essential component of the tol-dependent translocation system, and its protein-protein interaction with the translocation domain of colicin E9. Structure, 8 (1). pp. 57-66. ISSN 0969-2126

Leech, Andrew, Mattei, Benedetta, Federici, Luca, De Lorenzo, Giuli and Hemmings, Andrew M. (2000) Preliminary X-ray crystallographic analysis of a plant defence protein, the polygalacturonase-inhibiting protein from Phaseolus vulgaris. Acta Crystallographica Section D: Biological Crystallography, 56 (1). pp. 98-100. ISSN 0907-4449

Boetzel, Ruth, Czisch, Michael, Kaptein, Robert, Hemmings, Andrew M., James, Richard, Kleanthous, Colin and Moore, Geoffrey R. (2000) NMR investigation of the interaction of the inhibitor protein Im9 with its partner DNase. Protein Science, 9 (9). pp. 1709-1718. ISSN 0961-8368

Carr, S., Walker, D., James, R., Kleanthous, C. and Hemmings, A. M. (2000) Crystallization of the cytotoxic domain of a ribosome-inactivating colicin in complex with its immunity protein. Acta Crystallographica Section D: Biological Crystallography, 56 (12). pp. 1630-1633. ISSN 0907-4449

Whittaker, Sara B.-M., Moore, Geoffrey R., Hemmings, Andrew M., Czisch, Michael, Wechselberger, Rainer, Kaptein, Robert, James, Richard and Kleanthous, Colin (2000) Slow conformational dynamics of an endonuclease persist in its complex with its natural protein inhibitor. Protein Science, 9 (4). pp. 713-720. ISSN 0961-8368

Kühlmann, Ulrike C., Moore, Geoffrey R., James, Richard, Kleanthous, Colin and Hemmings, Andrew M. (1999) Structural parsimony in endonuclease active sites:Should the number of homing endonuclease families be redefined? FEBS Letters, 463 (1-2). pp. 1-2. ISSN 0014-5793

Pommer, Ansgar J., Kühlmann, Ulrike C., Cooper, Alan, Hemmings, Andrew M., Moore, Geoffrey R., James, Richard and Kleanthous, Colin (1999) Homing in on the role of transition metals in the HNH motif of colicin endonucleases. Journal of Biological Chemistry, 274 (38). pp. 27153-27160. ISSN 0021-9258

Bamford, Vicki, Dobbin, Paul S., Lee, Sor Cheng, Reilly, Ann, Powell, Anne K., Richardson, David J. and Hemmings, Andrew M. (1999) Crystallization and preliminary X-ray crystallographic analysis of a periplasmic tetrahaem flavocytochrome c3 from Shewanella frigidimarina NCIMB400 which has fumarate reductase activity. Acta Crystallographica Section D: Biological Crystallography, 55 (6). pp. 1222-1225. ISSN 0907-4449

Leckie, F., Mattei, B., Capodicasa, C., Hemmings, A., Nuss, L., Aracri, B., De Lorenzo, G. and Cervone, F. (1999) The specificity of polygalacturonase-inhibiting protein (PGIP):A single amino acid substitution in the solvent-exposed β-strand/β-turn region of the leucine-rich repeats (LRRs) confers a new recognition capability. EMBO Journal, 18 (9). pp. 2352-2363. ISSN 0261-4189

Kleanthous, C., James, R., Hemmings, A. M. and Moore, G. R. (1999) Protein antibiotics and their inhibitors. In: Biochemical Society Transactions. Biochemical Society Transactions, 27 (2). Portland Press Ltd., pp. 63-67.

Kühlmann, Ulrike C., Kleanthous, Colin, James, Richard, Moore, Geoffrey R. and Hemmings, Andrew M. (1999) Preliminary X-ray crystallographic analysis of the complex between the DNAase domain of colicin E9 and its cognate immunity protein. Acta Crystallographica Section D: Biological Crystallography, 55 (1). pp. 256-259. ISSN 0907-4449

Bamford, Vicki, Dobbin, Paul S., Richardson, David J. and Hemmings, Andrew M. (1999) Open conformation of a flavocytochrome c3 fumarate reductase. Nature Structural Biology, 6 (12). pp. 1104-1107. ISSN 1072-8368

Hannan, Jonathan P., Whittaker, Sara B.-M., Davy, Sharon L., Kühlmann, Ulrike C., Pommer, Ansgar J., Hemmings, Andrew M., James, Richard, Kleanthous, Colin and Moore, Geoffrey R. (1999) NMR study of Ni2+ binding to the H-N-H endonuclease domain of colicin E9. Protein Science, 8 (8). pp. 1711-1713. ISSN 0961-8368

Kleanthous, Colin, Kühlmann, Ulrike C., Pommer, Ansgar J., Ferguson, Neil, Radford, Sheena E., Moore, Geoffrey R., James, Richard and Hemmings, Andrew M. (1999) Structural and mechanistic basis of immunity toward endonuclease colicins. Nature Structural Biology, 6. pp. 243-252. ISSN 1072-8368

Boetzel, Ruth, Czisch, Michael, MacDonald, Colin J., Kaptein, Robert, Hemmings, Andrew M., James, Richard, Kleanthous, Colin and Moore, Geoffrey R. (1998) Assignment of 1H, 13C and 15N signals of the inhibitor protein Im9 bound to the DNase domain of colicin E9. Journal of Biomolecular NMR, 12. pp. 567-568. ISSN 0925-2738

Li, Wei, Hamill, Stefan J., Hemmings, Andrew M., Moore, Geoffrey R., James, Richard and Kleanthous, Colin (1998) Dual recognition and the role of specificity-determining residues in colicin E9 DNase-immunity protein interactions. Biochemistry, 37 (34). pp. 11771-11779. ISSN 0006-2960

Kajiwara, Hideyuki and Hemmings, Andrew M. (1998) Capillary electrophoretic analysis of ginseng polypeptide. Electrophoresis, 19 (8-9). pp. 1270-1274. ISSN 0173-0835

Kleanthous, Colin, Hemmings, Andrew M., Moore, Geoffrey R. and James, Richard (1998) Immunity proteins and their specificity for endonuclease colicins:Telling right from wrong in protein-protein recognition. Molecular Microbiology, 28 (2). pp. 227-233. ISSN 0950-382X

Kajiwara, Hideyuki, Hemmings, Andrew M. and Hirano, Hisashi (1996) Evidence of metal binding activities of pentadecapeptide from Panax ginseng. Journal of Chromatography B: Biomedical Applications, 687 (2). pp. 443-448. ISSN 1572-6495

O'Hara, Bernard P., Hemmings, Andrew M., Buttle, David J. and Pearl, Laurence H. (1995) Crystal structure of glycyl endopeptidase from Carica papaya: A cysteine endopeptidase of unusual substrate specificity. Biochemistry, 34 (40). pp. 13190-13195. ISSN 0006-2960

Watanabe, Yoshihiro, Barbashov, Sergei F., Komatsu, Setsuko, Hemmings, Andrew M., Miyagi, Masaru, Tsunasawa, Susumu and Hirano, Hisashi (1994) A Peptide that Stimulates Phosphorylation of the Plant Insulin‐Binding Protein:Isolation, Primary Structure and cDNA Cloning. European Journal of Biochemistry, 224 (1). pp. 167-172. ISSN 0014-2956

Pearl, Laurence H., Demasi, Domenico, Hemmings, Andrew M., Sica, Filomena, Mazzarella, Lelio, Raia, Carlo A., D'Auria, Sabato and Rossi, Mosè (1993) Crystallization and preliminary X-ray analysis of an NAD+-dependent alcohol dehydrogenase from the extreme thermophilic archaebacterium Sulfolobus solfataricus. Journal of Molecular Biology, 229 (3). pp. 782-784. ISSN 0022-2836

Pearl, Laurence H., Hemmings, Andrew M., Nucci, Roberto and Rossi, Mosé (1993) Crystallization and preliminary X-ray analysis of the β-galactosidase from the extreme thermophilic archaebacterium Sulfolobus solfataricus. Journal of Molecular Biology, 229 (2). pp. 561-563. ISSN 0022-2836

Hemmings, A. M., Chang, Wen-rui and Liang, Dong-cai (1992) Theoretical approaches to protein structure-function analysis (I). -Directed perturbation conformational analysis. Science in China (Scientia Sinica) Series B, 35 (3). pp. 304-318. ISSN 1001-652X

Wilson, Stuart A., Chayen, Naomi E., Hemmings, Andrew M., Drew, Robert E. and Pearl, Laurence H. (1991) Crystallization of and preliminary X-ray data for the negative regulator (AmiC) of the amidase operon of Pseudomonas aeruginosa. Journal of Molecular Biology, 222 (4). pp. 869-871. ISSN 0022-2836

Blundell, Tom L., Lapatto, Risto, Wilderspin, Andrew F., Hemmings, Andrew M., Hobart, Peter M., Danley, Dennis E. and Whittle, Peter J. (1990) The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS. Trends in Biochemical Sciences, 15 (11). pp. 425-430. ISSN 0968-0004

Lapatto, Risto, Blundell, Tom, Hemmings, Andrew, Overington, John, Wilderspin, Andrew, Wood, Stephen, Merson, James R., Whittle, Peter J., Danley, Dennis E., Geoghegan, Kieran F., Hawrylik, Steven J., Lee, S. Edward, Scheld, Kathryn G. and Hobart, Peter M. (1989) X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes. Nature, 342 (6247). pp. 299-302. ISSN 0028-0836

Cooper, Jon, Foundling, Steve, Hemmings, Andrew, Blundell, Tom, Jones, D. Michael, Hallett, Allan and Szelke, Michael (1987) The structure of a synthetic pepsin inhibitor complexed with endothiapepsin. European Journal of Biochemistry, 169 (1). pp. 215-221. ISSN 0014-2956

Cooper, J. B., Foundling, S. I., Hemmings, A., Watson, F. E., Sibanda, B. L., Blundell, T. L., Jones, D. M., Hallett, A., Atrash, B. and Szelke, M. (1987) Inhibitors of aspartic proteinases and their relevance to the design of antihypertensive agents. In: Biochemical Society Transactions. Biochemical Society Transactions, 15 (4). Portland Press Ltd., pp. 751-754.

Foundling, S. I., Cooper, J., Watson, F. E., Cleasby, A., Pearl, L. H., Sibanda, B. L., Hemmings, A., Wood, S. P., Blundell, T. L., Valler, M. J., Norey, C. G., Kay, J., Boger, J., Dunn, B. M., Leckie, B. J., Jone, D. M., Atrash, B., Hallett, A. and Szelke, M. (1987) High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes. Nature, 327 (6120). pp. 349-352. ISSN 0028-0836

Foundling, S. I., Cooper, J., Watson, F. E., Pearl, L. H., Hemmings, A., Wood, S. P., Blundell, T., Hallett, A., Jones, D. M., Sueiras, J., Atrash, B. and Szelke, M. (1987) Crystallographic studies of reduced bond inhibitors complexed with an aspartic proteinase. Journal of Cardiovascular Pharmacology, 10. pp. 59-68. ISSN 0160-2446

Freeman, C. M., Catlow, C. R. A., Hemmings, A. M. and Hider, R. C. (1986) The conformation of apamin. FEBS Letters, 197 (1-2). pp. 289-296. ISSN 0014-5793

Hemmings, A. M., Foundling, S. I., Sibanda, B. L., Wood, S. P., Pearl, L. H. and Blundell, T. (1985) Energy calculations on aspartic proteinases:Human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142. In: Biochemical Society Transactions. Portland Press Ltd., pp. 1036-1041.