Items where Author is "Beekman, Andrew"

Article

Malbon, Alexandra, Czopek, Alicja, Beekman, Andrew, Goddard, Zoë, Boyle, Aileen, Ivy, Jessica, Stewart, Kevin, Denham, Scott G., Simpson, Joanna, Homer, Natalie Z. M., Walker, Brian, Dhaun, Neeraj, Bailey, Matthew and Morgan, Ruth (2025) Carbonyl Reductase 1: A novel regulator of blood pressure in Down Syndrome. Bioscience Reports. ISSN 0144-8463

van Wier, Suzanne P. and Beekman, Andrew M. (2025) Peptide design to control protein–protein interactions. Chemical Society Reviews. ISSN 0306-0012

Bidula, Stefan, Piyasirananda, Waraporn, Bielecka, Hanna, Bibič, Lučka, Beekman, Andrew and Stokes, Leanne (2024) Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7. Purinergic Signalling. ISSN 1573-9538

Hayward, Deanne, Goddard, Zoë R., Cominetti, Marco M. D., Searcey, Mark and Beekman, Andrew M. (2024) Light-activated azobenzene peptide inhibitor of the PD-1/PD-L1 interaction. Chemical Communications, 60 (63). pp. 8228-8231. ISSN 1359-7345

Cominetti, Marco M. D., Goddard, Zoë R., Hood, Bethany R., Beekman, Andrew M., O'Connell, Maria A. and Searcey, Mark (2024) Borylation via iridium catalysed C–H activation: a new concise route to duocarmycin derivatives. Organic & Biomolecular Chemistry, 22 (27). pp. 5603-5607. ISSN 1477-0520

Hayward, Deanne and Beekman, Andrew M. (2024) Strategies for converting turn-motif and cyclic peptides to small molecules for targeting protein–protein interactions. RSC Chemical Biology, 5 (3). pp. 198-208. ISSN 2633-0679

Stokes, Leanne, Bielecka, Hanna, Felgate, Matthew, Beekman, Andrew, Ngameni, Bathelemy, Chi, Godloves Fru, Stephenson, Richard and Bidula, Stefan (2021) Dioscin-related glycosides as positive allosteric modulators of P2X7 receptors. British Journal of Pharmacology, 178 (24). p. 4947. ISSN 0007-1188

Goddard, Zoë Rachael, Beekman, Andrew Michael, Cominetti, Marco M. D., O'Connell, Maria A., Chambrier, Isabelle, Cook, Michael J., Marin, Maria J., Russell, David A. and Searcey, Mark (2021) Peptide directed phthalocyanine-gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers. RSC Medicinal Chemistry, 12 (2). pp. 288-292. ISSN 2632-8682

Howell, Lesley Ann and Beekman, Andrew Michael (2021) In silico peptide-directed ligand design complements experimental peptide-directed binding for protein–protein interaction modulator discovery. RSC Chemical Biology, 2 (1). pp. 215-219. ISSN 2633-0679

Piyasirananda, Waraporn, Beekman, Andrew, Ganesan, A., Bidula, Stefan and Stokes, Leanne (2021) Insights into the structure-activity relationship of glycosides as positive allosteric modulators acting on P2X7 receptors. Molecular Pharmacology, 99 (2). pp. 163-174. ISSN 0026-895X

Cartwright, Oliver Charles, Beekman, Andrew Michael, Cominetti, Marco M. D., Russell, David A. and Searcey, Mark (2020) A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity. Bioconjugate Chemistry, 31 (7). 1745–1749. ISSN 1043-1802

Beekman, Andrew, Cominetti, Marco, Cartwright, Oliver, Boger, Dale L. and Searcey, Mark (2019) A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase. MedChemComm, 10 (12). pp. 2170-2174. ISSN 2040-2503

Beekman, Andrew M., Cominetti, Marco M. D., Walpole, Samuel J., Prabhu, Saurabh, O'Connell, Maria A., Angulo Alvarez, Jesus and Searcey, Mark (2019) Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design. Chemical Science, 10 (16). pp. 4502-4508. ISSN 2041-6520

Mills, Shirley, Howell, Lesley, Beekman, Andrew, Stokes, Leanne and Mueller, Anja (2018) Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4. Cellular Signalling, 42. 88–96. ISSN 0898-6568

Beekman, Andrew Michael, O'Connell, Maria Anne and Howell, Lesley Ann (2017) Peptide-directed binding for the discovery of modulators of α-helix-mediated protein-protein interactions: Proof-of-concept studies with the apoptosis regulator Mcl-1. Angewandte Chemie-International Edition, 56 (35). 10446–10450. ISSN 1433-7851

Myrtle, Jonathan D., Beekman, Andrew M. and Barrow, Russell A. (2016) Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis. Organic & Biomolecular Chemistry, 14 (35). pp. 8253-8260. ISSN 1477-0520

Beekman, Andrew M., O'Connell, Maria A. and Howell, Lesley A. (2016) Identification of small-molecule inhibitors of the antiapoptotic protein myeloid cell leukaemia-1 (Mcl-1). ChemMedChem, 11 (8). 840–844. ISSN 1860-7179

Howell, Lesley and Beekman, Andrew (2016) Small molecule and peptide inhibitors of the pro-survival protein Mcl-1. ChemMedChem, 11 (8). 802–813. ISSN 1860-7179

Beekman, Andrew M., Wossa, Stewart W., Kevo, Oromo, Ma, Paul and Barrow, Russell A. (2015) Discovery and synthesis of Boletopsins 13 and 14, brominated fungal metabolites of terrestrial origin. Journal of Natural Products, 78 (8). pp. 2133-2135. ISSN 0163-3864

Beekman, Andrew M. and Barrow, Russell A. (2015) Syntheses of Cytosporones A, C, J, K, and N, Metabolites from Medicinal Fungi. Australian Journal of Chemistry, 68 (10). pp. 1583-1592. ISSN 0004-9425

Beekman, Andrew M. and Barrow, Russell A. (2014) Fungal metabolites as pharmaceuticals. Australian Journal of Chemistry, 67 (6). pp. 827-843. ISSN 0004-9425

Beekman, Andrew M. and Barrow, Russell A. (2014) Syntheses of the fungal metabolites Boletopsins 7, 11, and 12 from the Papua New Guinea medicinal mushroom Boletopsis sp. The Journal of Organic Chemistry, 79 (3). pp. 1017-1024. ISSN 0022-3263

Beekman, Andrew Michael and Barrow, Russell Allan (2013) Stereochemical assignment of the fungal metabolites Pestalotiopsones D and E through enantiopure synthesis. Journal of Natural Products, 76 (11). pp. 2054-2059. ISSN 0163-3864

Wossa, Stewart W., Beekman, Andrew M., Ma, Paul, Kevo, Oromo and Barrow, Russell A. (2013) Identification of boletopsin 11 and 12, antibiotics from the traditionally used fungus Boletopsis sp. Asian Journal of Organic Chemistry, 2 (7). pp. 565-567. ISSN 2193-5807

Beekman, Andrew Michael, Castillo Martinez, Edwin and Barrow, Russell Allan (2013) First syntheses of the biologically active fungal metabolites pestalotiopsones A, B, C and F. Organic & Biomolecular Chemistry, 11 (7). pp. 1109-1115. ISSN 1477-0520

Book Section

Beekman, Andrew, Cominetti, Marco M D and Searcey, Mark (2019) Duocarmycins as Antibody–Drug Conjugate (ADC) Payloads. In: Cytotoxic Payloads for Antibody-Drug Conjugates. Royal Society of Chemistry. ISBN 978-1-78801-077-1