Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis

Myrtle, Jonathan D., Beekman, Andrew M. and Barrow, Russell A. (2016) Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis. Organic & Biomolecular Chemistry, 14 (35). pp. 8253-8260. ISSN 1477-0520

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Abstract

A new antibiotic natural product, ravynic acid, has been isolated from a Penicillium sp. of fungus, collected from Ravensbourne National Park. The 3-acylpolyenyne tetramic acid structure was definitively elucidated via synthesis. Highlights of the synthetic method include the heat induced formation of the 3-acylphosphorane tetramic acid and a selective Wittig cross-coupling to efficiently prepare the natural compounds carbon skeleton. The natural compound was shown to inhibit the growth of Staphylococcus aureus down to concentrations of 2.5 µg mL−1.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 13 Apr 2017 05:08
Last Modified: 22 Apr 2020 02:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/63239
DOI: 10.1039/C6OB00938G

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