Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis

Myrtle, Jonathan D., Beekman, Andrew M. ORCID: https://orcid.org/0000-0002-3056-6406 and Barrow, Russell A. (2016) Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis. Organic & Biomolecular Chemistry, 14 (35). pp. 8253-8260. ISSN 1477-0520

Full text not available from this repository. (Request a copy)

Abstract

A new antibiotic natural product, ravynic acid, has been isolated from a Penicillium sp. of fungus, collected from Ravensbourne National Park. The 3-acylpolyenyne tetramic acid structure was definitively elucidated via synthesis. Highlights of the synthetic method include the heat induced formation of the 3-acylphosphorane tetramic acid and a selective Wittig cross-coupling to efficiently prepare the natural compounds carbon skeleton. The natural compound was shown to inhibit the growth of Staphylococcus aureus down to concentrations of 2.5 µg mL−1.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: Pure Connector
Date Deposited: 13 Apr 2017 05:08
Last Modified: 01 Oct 2022 02:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/63239
DOI: 10.1039/C6OB00938G

Actions (login required)

View Item View Item