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Myrtle, Jonathan D., Beekman, Andrew M. 
ORCID: https://orcid.org/0000-0002-3056-6406 and Barrow, Russell A.
(2016)
Ravynic acid, an antibiotic polyeneyne tetramic acid from Penicillium sp. elucidated through synthesis.
Organic & Biomolecular Chemistry, 14 (35).
pp. 8253-8260.
ISSN 1477-0520
Abstract
A new antibiotic natural product, ravynic acid, has been isolated from a Penicillium sp. of fungus, collected from Ravensbourne National Park. The 3-acylpolyenyne tetramic acid structure was definitively elucidated via synthesis. Highlights of the synthetic method include the heat induced formation of the 3-acylphosphorane tetramic acid and a selective Wittig cross-coupling to efficiently prepare the natural compounds carbon skeleton. The natural compound was shown to inhibit the growth of Staphylococcus aureus down to concentrations of 2.5 µg mL−1.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Depositing User: | Pure Connector |
| Date Deposited: | 13 Apr 2017 05:08 |
| Last Modified: | 22 Oct 2022 02:13 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/63239 |
| DOI: | 10.1039/C6OB00938G |
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