Items where Author is "Troeberg, Linda"

Steverding, Dietmar, Tinson, Ryan A. J., Piras, Monica, Wren, Stephen P., Rushworth, Stuart A., Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2024) Suramin: Effectiveness of analogues reveals structural features that are important for the potent trypanocidal activity of the drug. Experimental Parasitology, 260. ISSN 0014-4894

Johnson, Benjamin B., Cosson, Marie-Victoire, Tsansizi, Lorenza I., Holmes, Terri L., Gilmore, Tegan, Hampton, Katherine, Song, Ok-Ryul, Vo, Nguyen T. N., Nasir, Aishah, Chabronova, Alzbeta, Denning, Chris, Peffers, Mandy J., Merry, Catherine L. R., Whitelock, John, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Rushworth, Stuart A., Bernardo, Andreia S. and Smith, James G. W. ORCID: https://orcid.org/0000-0003-0427-8678 (2024) Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes. Cell Reports, 43 (1). ISSN 2211-1247

Steverding, Dietmar and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2024) 100 years since the publication of the suramin formula. Parasitology Research, 123. ISSN 0932-0113

Green, Jonathan, Tinson, Ryan A. J., Betts, Jacob H. J., Piras, Monica, Pelut, Aylin, Steverding, Dietmar, Wren, Stephen, Searcey, Mark ORCID: https://orcid.org/0000-0003-2273-8949 and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2023) Suramin analogues protect cartilage against osteoarthritic breakdown by increasing levels of tissue inhibitor of metalloproteinases 3 (TIMP-3) in the tissue. Bioorganic & Medicinal Chemistry, 92. ISSN 0968-0896

Calligaris, Matteo, Yang, Chun Y., Bonelli, Simone, Spanò, Donatella Pia, Müller, Stephan A., Lichtenthaler, Stefan F., Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Scilabra, Simone D. (2023) Identification of membrane proteins regulated by ADAM15 by SUSPECS proteomics. Frontiers in Molecular Biosciences, 10. ISSN 2296-889X

Fowkes, Milan M., Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Brennan, Paul E., Vincent, Tonia L., Meldal, Morten and Lim, Ngee H. (2023) Development of selective ADAMTS-5 peptide substrates to monitor proteinase activity. Journal of Medicinal Chemistry, 66 (5). pp. 3522-3539. ISSN 0022-2623

Paskins, Zoe, Farmer, Clare E., Manning, Fay, Andersson, David A., Barlow, Tim, Bishop, Felicity L., Brown, Christopher A., Clark, Amanda, Clark, Emma M., Dulake, Debra, Gulati, Malvika, Le Maitre, Christine L., Jones, Richard K., Loughlin, John, Mason, Deborah J., McCarron, Maura, Millar, Neil L., Pandit, Hemant, Peat, George, Richardson, Stephen M., Salt, Emma J., Taylor, E. Jane, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Wilcox, Ruth K., Wise, Elspeth, Wilkinson, Colin and Watt, Fiona E. and Musculoskeletal Disorders Research Advisory Group Versus Arthritis (2022) Research priorities to reduce the impact of musculoskeletal disorders: A priority setting exercise with the child health and nutrition research initiative method. The Lancet Rheumatology, 4 (9). e635-e645. ISSN 2665-9913

Yang, Chun Yao, Bonelli, Simone, Calligaris, Matteo, Carreca, Anna Paola, Müller, Stephan A., Lichtenthaler, Stefan F., Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Scilabra, Simone D. (2022) Quantitative proteomics reveals that ADAM15 can have proteolytic-independent functions in the steady state. Membranes, 12 (6). ISSN 2077-0375

Vincent, Tonia L., McClurg, Oliver and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2022) The extracellular matrix of articular cartilage controls the bioavailability of pericellular matrix-bound growth factors to drive tissue homeostasis and repair. International Journal of Molecular Sciences, 23 (11). ISSN 1661-6596

Vincent, Tonia L., Alliston, Tamara, Kapoor, Mohit, Loeser, Richard F., Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Little, Christopher B. (2022) Osteoarthritis pathophysiology:Therapeutic target discovery may require a multifaceted approach. Clinics in Geriatric Medicine, 38 (2). pp. 193-219. ISSN 0749-0690

Kadurin, Ivan, Dahimene, Shehrazade, Page, Karen M., Ellaway, Joseph I. J., Chaggar, Kanchan, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Nagase, Hideaki and Dolphin, Annette C. (2022) ADAM17 mediates proteolytic maturation of voltage-gated calcium channel auxiliary α2δ subunits, and enables calcium current enhancement. Function, 3 (3). ISSN 2633-8823

Karamanos, Nikos K., Theocharis, Achilleas D., Piperigkou, Zoi, Manou, Dimitra, Passi, Alberto, Skandalis, Spyros S., Vynios, Demitrios H., Orian‐Rousseau, Véronique, Ricard‐Blum, Sylvie, Schmelzer, Christian E. H., Duca, Laurent, Durbeej, Madeleine, Afratis, Nikolaos A., Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Franchi, Marco, Masola, Valentina and Onisto, Maurizio (2021) A guide to the composition and functions of the extracellular matrix. FEBS Journal, 288 (24). pp. 6850-6912. ISSN 1742-464X

McClurg, Oliver, Tinson, Ryan and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2021) Targeting cartilage degradation in osteoarthritis. Pharmaceuticals, 14 (2). ISSN 1424-8247

Yang, C. Y., Chanalaris, A., Bonelli, S., McClurg, O., Hiles, G. Lorenzatti, Cates, A. l., Zarebska, J. Miotla, Vincent, T. L., Day, M. L., Müller, S. A., Lichtenthaler, S. F., Nagase, H., Scilabra, S. D. and Troeberg, L. ORCID: https://orcid.org/0000-0003-0939-4651 (2020) Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage. Osteoarthritis and Cartilage Open, 2 (4). ISSN 2665-9131

Reijmers, Rogier M., Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Lord, Megan S. and Petrey, Aaron C. (2020) Editorial: Proteoglycans and Glycosaminoglycan Modification in Immune Regulation and Inflammation. Frontiers in Immunology, 11. ISSN 1664-3224

Carreca, Anna P., Pravatà, Veronica M., Markham, Matthew, Bonelli, Simone, Murphy, Gillian, Nagase, Hideaki, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Scilabra, Simone D. (2020) TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1. Scientific Reports, 10. ISSN 2045-2322

Yang, Chun-Yao, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Scilabra, Simone D (2020) Quantitative Mass Spectrometry-Based Secretome Analysis as a Tool to Investigate Metalloprotease and TIMP Activity. In: ADAMTS Proteases. Methods in Molecular Biology, 2043 . Springer, pp. 265-273. ISBN 978-1-4939-9697-1

Mohammed, Rebar N, Wehenkel, Sophie C, Galkina, Elena V, Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H Angharad, Ohme, Julia, Bridgeman, John S, Durairaj, Ruban R P, Moon, Owen R, Ladell, Kristin, Miners, Kelly L, Dolton, Garry, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A, Matthews, R James, Knäuper, Vera and Ager, Ann (2019) ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports, 9. ISSN 2045-2322

Schubert, Kristin, Collins, Laura E., Green, Patricia, Nagase, Hideaki and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2019) LRP1 controls TNF release via the TIMP-3/ADAM17 axis in endotoxin-activated macrophages. Journal of Immunology, 202 (5). pp. 1501-1509. ISSN 0022-1767

Chanalaris, Anastasios, Clarke, Hannah, Guimond, Scott E., Vincent, Tonia L., Turnbull, Jeremy E. and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2019) Heparan sulfate proteoglycan synthesis is dysregulated in human osteoarthritic cartilage. American Journal of Pathology, 189 (3). pp. 632-647. ISSN 0002-9440

Swart, Maarten and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2019) Effect of polarization and chronic inflammation on macrophage expression of heparan sulfate proteoglycans and biosynthesis enzymes. Journal of Histochemistry and Cytochemistry, 67 (1). pp. 9-27. ISSN 0022-1554

Collins, Laura E and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2019) Heparan sulfate as a regulator of inflammation and immunity. Journal of Leukocyte Biology, 105 (1). pp. 81-92. ISSN 0741-5400

Scilabra, Simone D, Pigoni, Martina, Pravatá, Veronica, Schätzl, Tobias, Müller, Stephan A, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Lichtenthaler, Stefan F (2018) Increased TIMP-3 expression alters the cellular secretome through dual inhibition of the metalloprotease ADAM10 and ligand-binding of the LRP-1 receptor. Scientific Reports, 8. ISSN 2045-2322

Lund, Jacob, Elimar Bitsch, Anne Mette, Grønbech Rasch, Morten, Enoksson, Mari, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Nagase, Hideaki, Loftager, Mette, Overgaard, Michael Toft and Petersen, Helle Heibroch (2018) Monoclonal antibodies targeting the disintegrin-like domain of ADAMDEC1 modulates the proteolytic activity and enables quantification of ADAMDEC1 protein in human plasma. MAbs, 10 (1). pp. 118-128. ISSN 1942-0862

Chanalaris, Anastasios, Doherty, Christine, Marsden, Brian D, Bambridge, Gabriel, Wren, Stephen P, Nagase, Hideaki and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2017) Suramin inhibits osteoarthritic cartilage degradation by increasing extracellular levels of chondroprotective tissue inhibitor of metalloproteinases 3. Molecular Pharmacology, 92 (4). pp. 459-468. ISSN 0026-895X

Yang, C-Y, Chanalaris, A and Troeberg, L ORCID: https://orcid.org/0000-0003-0939-4651 (2017) ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'. Osteoarthritis and Cartilage, 25 (7). pp. 1000-1009. ISSN 1063-4584

Yamamoto, Kazuhiro, Santamaria, Salvatore, Botkjaer, Kenneth A, Dudhia, Jayesh, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Itoh, Yoshifumi, Murphy, Gillian and Nagase, Hideaki (2017) Inhibition of shedding of low-density lipoprotein receptor-related protein 1 reverses cartilage matrix degradation in osteoarthritis. Arthritis & Rheumatology, 69 (6). pp. 1246-1256. ISSN 2326-5191

Scilabra, Simone D, Yamamoto, Kazuhiro, Pigoni, Martina, Sakamoto, Kazuma, Müller, Stephan A, Papadopoulou, Alkmini, Lichtenthaler, Stefan F, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Nagase, Hideaki and Kadomatsu, Kenji (2017) Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1):Development of a "TRAP" to increase levels of TIMP-3 in the tissue. Matrix Biology, 59. pp. 69-79. ISSN 0945-053X

Yamamoto, Kazuhiro, Okano, Hiroshi, Miyagawa, Wakako, Visse, Robert, Shitomi, Yasuyuki, Santamaria, Salvatore, Dudhia, Jayesh, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Strickland, Dudley K, Hirohata, Satoshi and Nagase, Hideaki (2016) MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1. Matrix Biology, 56. pp. 57-73. ISSN 0945-053X

Doherty, Christine M., Visse, Robert, Dinakarpandian, Deendayal, Strickland, Dudley K., Nagase, Hideaki and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2016) Engineered tissue inhibitor of metalloproteinases-3 variants resistant to endocytosis have prolonged chondroprotective activity. The Journal of Biological Chemistry, 291 (42). pp. 22160-22172. ISSN 0021-9258

Ismail, Heba M., Miotla-Zarebska, Jadwiga, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Tang, Xiaodi, Stott, Bryony, Yamamoto, Kazuhiro, Nagase, Hideaki, Fosang, Amanda J., Vincent, Tonia L. and Saklatvala, Jeremy (2016) Brief Report: JNK-2 controls aggrecan degradation in murine articular cartilage and the development of experimental osteoarthritis. Arthritis & Rheumatology, 68 (5). pp. 1165-1171. ISSN 2326-5191

Ismail, Heba M, Yamamoto, Kazuhiro, Vincent, Tonia L, Nagase, Hideaki, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Saklatvala, Jeremy (2015) Interleukin-1 acts via the JNK-2 signaling pathway to induce aggrecan degradation by human chondrocytes. Arthritis & Rheumatology, 67 (7). pp. 1826-1836. ISSN 2326-5191

Lund, Jacob, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Kjeldal, Henrik, Olsen, Ole H, Nagase, Hideaki, Sørensen, Esben S, Stennicke, Henning R, Petersen, Helle H and Overgaard, Michael T (2015) Evidence for restricted reactivity of ADAMDEC1 with protein substrates and endogenous inhibitors. The Journal of Biological Chemistry, 290 (10). pp. 6620-6629. ISSN 0021-9258

Yamamoto, Kazuhiro, Murphy, Gillian and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2015) Extracellular regulation of metalloproteinases. Matrix Biology, 44-46. pp. 255-263. ISSN 0945-053X

Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Lazenbatt, Christopher, Anower-E-Khuda, Md Ferdous, Freeman, Craig, Federov, Oleg, Habuchi, Hiroko, Habuchi, Osami, Kimata, Koji and Nagase, Hideaki (2014) Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3. Chemistry & Biology, 21 (10). pp. 1300-1309. ISSN 1074-5521

Yamamoto, Kazuhiro, Owen, Kathryn, Parker, Andrew E, Scilabra, Simone D, Dudhia, Jayesh, Strickland, Dudley K, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Nagase, Hideaki (2014) Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4):functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding. The Journal of Biological Chemistry, 289 (10). pp. 6462-6474. ISSN 0021-9258

Yamamoto, Kazuhiro, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Scilabra, Simone D, Pelosi, Michele, Murphy, Christopher L, Strickland, Dudley K and Nagase, Hideaki (2013) LRP-1-mediated endocytosis regulates extracellular activity of ADAMTS-5 in articular cartilage. The FASEB Journal, 27 (2). pp. 511-521. ISSN 0892-6638

Scilabra, Simone D, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Yamamoto, Kazuhiro, Emonard, Hervé, Thøgersen, Ida, Enghild, Jan J, Strickland, Dudley K and Nagase, Hideaki (2013) Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1. The Journal of Biological Chemistry, 288 (1). pp. 332-342. ISSN 0021-9258

Lo Cicero, Alessandra, Majkowska, Iwona, Nagase, Hideaki, Di Liegro, Italia and Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 (2012) Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity. Matrix Biology, 31 (4). pp. 229-233. ISSN 0945-053X

Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Mulloy, Barbara, Ghosh, Peter, Lee, Meng-Huee, Murphy, Gillian and Nagase, Hideaki (2012) Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex. Biochemical Journal, 443 (1). pp. 307-315. ISSN 0264-6021

Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651 and Nagase, Hideaki (2012) Proteases involved in cartilage matrix degradation in osteoarthritis. Biochimica et Biophysica Acta, 1824 (1). pp. 133-145. ISSN 0006-3002

Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Fushimi, Kazunari, Scilabra, Simone D, Nakamura, Hiroyuki, Dive, Vincent, Thøgersen, Ida B, Enghild, Jan J and Nagase, Hideaki (2009) The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3. Matrix Biology, 28 (8). pp. 463-469. ISSN 0945-053X

Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Fushimi, Kazunari, Khokha, Rama, Emonard, Hervé, Ghosh, Peter and Nagase, Hideaki (2008) Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases. The FASEB Journal, 22 (10). pp. 3515-3524. ISSN 0892-6638

Fushimi, Kazunari, Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Nakamura, Hiroyuki, Lim, Ngee Han and Nagase, Hideaki (2008) Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity. The Journal of Biological Chemistry, 283 (11). pp. 6706-6016. ISSN 0021-9258

Troeberg, Linda ORCID: https://orcid.org/0000-0003-0939-4651, Tanaka, Mitsuo, Wait, Robin, Shi, Yeunian E, Brew, Keith and Nagase, Hideaki (2002) E. coli expression of TIMP-4 and comparative kinetic studies with TIMP-1 and TIMP-2:insights into the interactions of TIMPs and matrix metalloproteinase 2 (gelatinase A). Biochemistry, 41 (50). pp. 15025-1535. ISSN 0006-2960