Targeting cartilage degradation in osteoarthritis

McClurg, Oliver, Tinson, Ryan and Troeberg, Linda (2021) Targeting cartilage degradation in osteoarthritis. Pharmaceuticals, 14 (2). ISSN 1424-8247

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Abstract

Osteoarthritis is a common, degenerative joint disease with significant socio-economic impact worldwide. There are currently no disease-modifying drugs available to treat the disease, making this an important area of pharmaceutical research. In this review, we assessed approaches being explored to directly inhibit metalloproteinase-mediated cartilage degradation and to counteract cartilage damage by promoting growth factor-driven repair. Metalloproteinase-blocking antibodies are discussed, along with recent clinical trials on FGF18 and Wnt pathway inhibitors. We also considered dendrimer-based approaches being developed to deliver and retain such therapeutics in the joint environment. These may reduce systemic side effects while improving local half-life and concentration. Development of such targeted anabolic therapies would be of great benefit in the osteoarthritis field.

Item Type: Article
Uncontrolled Keywords: cartilage,metalloproteinase,osteoarthritis,targeting,molecular medicine,pharmaceutical science ,/dk/atira/pure/subjectarea/asjc/1300/1313
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 27 Feb 2021 01:04
Last Modified: 05 Jul 2021 00:12
URI: https://ueaeprints.uea.ac.uk/id/eprint/79342
DOI: 10.3390/ph14020126

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