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McClurg, Oliver, Tinson, Ryan and Troeberg, Linda 
ORCID: https://orcid.org/0000-0003-0939-4651
(2021)
Targeting cartilage degradation in osteoarthritis.
Pharmaceuticals, 14 (2).
ISSN 1424-8247
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Abstract
Osteoarthritis is a common, degenerative joint disease with significant socio-economic impact worldwide. There are currently no disease-modifying drugs available to treat the disease, making this an important area of pharmaceutical research. In this review, we assessed approaches being explored to directly inhibit metalloproteinase-mediated cartilage degradation and to counteract cartilage damage by promoting growth factor-driven repair. Metalloproteinase-blocking antibodies are discussed, along with recent clinical trials on FGF18 and Wnt pathway inhibitors. We also considered dendrimer-based approaches being developed to deliver and retain such therapeutics in the joint environment. These may reduce systemic side effects while improving local half-life and concentration. Development of such targeted anabolic therapies would be of great benefit in the osteoarthritis field.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cartilage,metalloproteinase,osteoarthritis,targeting,molecular medicine,pharmaceutical science ,/dk/atira/pure/subjectarea/asjc/1300/1313 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Pharmacy |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 27 Feb 2021 01:04 |
| Last Modified: | 19 Oct 2023 02:55 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/79342 |
| DOI: | 10.3390/ph14020126 |
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