Proteases involved in cartilage matrix degradation in osteoarthritis

Troeberg, Linda and Nagase, Hideaki (2012) Proteases involved in cartilage matrix degradation in osteoarthritis. Biochimica et Biophysica Acta, 1824 (1). pp. 133-145. ISSN 0006-3002

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Abstract

Osteoarthritis is a common joint disease for which there are currently no disease-modifying drugs available. Degradation of the cartilage extracellular matrix is a central feature of the disease and is widely thought to be mediated by proteinases that degrade structural components of the matrix, primarily aggrecan and collagen. Studies on transgenic mice have confirmed the central role of Adamalysin with Thrombospondin Motifs 5 (ADAMTS-5) in aggrecan degradation, and the collagenolytic matrix metalloproteinase MMP-13 in collagen degradation. This review discusses recent advances in current understanding of the mechanisms regulating expression of these key enzymes, as well as reviewing the roles of other proteinases in cartilage destruction. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome.

Item Type: Article
Additional Information: Copyright © 2011 Elsevier B.V. All rights reserved.
Uncontrolled Keywords: genetics,animals,metabolism,genetics,metabolism,physiology,humans,genetics,mice,models, biological,enzymology,genetics,proteolysis
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 08 Jan 2019 12:30
Last Modified: 22 Apr 2020 07:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/69489
DOI: 10.1016/j.bbapap.2011.06.020

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