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Troeberg, Linda 
ORCID: https://orcid.org/0000-0003-0939-4651 and Nagase, Hideaki
(2012)
Proteases involved in cartilage matrix degradation in osteoarthritis.
Biochimica et Biophysica Acta, 1824 (1).
pp. 133-145.
ISSN 0006-3002
Abstract
Osteoarthritis is a common joint disease for which there are currently no disease-modifying drugs available. Degradation of the cartilage extracellular matrix is a central feature of the disease and is widely thought to be mediated by proteinases that degrade structural components of the matrix, primarily aggrecan and collagen. Studies on transgenic mice have confirmed the central role of Adamalysin with Thrombospondin Motifs 5 (ADAMTS-5) in aggrecan degradation, and the collagenolytic matrix metalloproteinase MMP-13 in collagen degradation. This review discusses recent advances in current understanding of the mechanisms regulating expression of these key enzymes, as well as reviewing the roles of other proteinases in cartilage destruction. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright © 2011 Elsevier B.V. All rights reserved. |
| Uncontrolled Keywords: | genetics,animals,metabolism,genetics,metabolism,physiology,humans,genetics,mice,models, biological,enzymology,genetics,proteolysis |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 08 Jan 2019 12:30 |
| Last Modified: | 19 Oct 2023 02:20 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/69489 |
| DOI: | 10.1016/j.bbapap.2011.06.020 |
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