Items where Author is "Stokes, Leanne"

Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138, Piyasirananda, Waraporn, Bielecka, Hanna, Bibič, Lučka, Beekman, Andrew ORCID: https://orcid.org/0000-0002-3056-6406 and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2024) Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7. Purinergic Signalling. ISSN 1573-9538

Angsusing, Jaenjira, Singh, Sudarshan, Samee, Weerasak, Tadtong, Sarin, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, O'Connell, Maria ORCID: https://orcid.org/0000-0002-0267-0951, Bielecka, Hanna, Toolmal, Nopparut, Mangmool, Supachoke and Chittasupho, Chuda (2024) Anti-inflammatory activities of Yataprasen Thai traditional formulary and its active compounds, beta-amyrin and stigmasterol, in RAW264.7 and THP-1 cells. Pharmaceuticals, 17 (8). ISSN 1424-8247

Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138 and Sluyter, Ronald (2024) Purinergic P2X Receptors as Therapeutic Targets. In: Ion Channels as Targets in Drug Discovery. Springer, pp. 439-460. ISBN 9783031521966

Sluyter, Ronald, McEwan, Tahnee B.-D., Sophocleous, Reece A. and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2024) Methods for studying P2X4 receptor ion channels in immune cells. Journal of Immunological Methods, 526. ISSN 0022-1759

Dhuna, Kshitija, Helliwell, Ray, de Luca, Simone N., Spencer, Sarah J. and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2024) Ginsenosides enhance P2X7-dependent cytokine secretion from LPS-primed rodent macrophages. Purinergic Signalling, 20. 65–71. ISSN 1573-9538

Sluyter, Ronald, Sophocleous, Reece A. and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2023) P2X receptors: Insights from the study of the domestic dog. Neuropharmacology, 224. ISSN 0028-3908

Dane, Chianna, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 and Jorgensen, William T. (2022) P2X receptor antagonists and their potential as therapeutics: a patent review (2010-2021). Expert Opinion on Therapeutic Patents, 32 (7). pp. 769-790. ISSN 1354-3776

Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Bielecka, Hanna, Felgate, Matthew, Beekman, Andrew ORCID: https://orcid.org/0000-0002-3056-6406, Ngameni, Bathelemy, Chi, Godloves Fru, Stephenson, Richard and Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138 (2021) Dioscin-related glycosides as positive allosteric modulators of P2X7 receptors. British Journal of Pharmacology, 178 (24). p. 4947. ISSN 0007-1188

Piyasirananda, Waraporn, Beekman, Andrew ORCID: https://orcid.org/0000-0002-3056-6406, Ganesan, A. ORCID: https://orcid.org/0000-0003-4862-7999, Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138 and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2021) Insights into the structure-activity relationship of glycosides as positive allosteric modulators acting on P2X7 receptors. Molecular Pharmacology, 99 (2). pp. 163-174. ISSN 0026-895X

Bibič, Lučka and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2020) Revisiting the idea that amyloid-β peptide acts as an agonist for P2X7. Frontiers in Molecular Neuroscience, 13. ISSN 1662-5099

Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138, Bibic, Lucka, Moulton, Adrienne, Zhang, Jiayi and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2020) Revisiting the past to enhance the future:Traditional medicinal plant extracts in the discovery of novel drug lead to target P2X7. British Journal of Pharmacology, 177 (11). pp. 2628-2629. ISSN 0007-1188

Sophocleous, Reece A., Berg, Tracey, Finol‐Urdaneta, Rocio K., Sluyter, Vanessa, Keshiya, Shikara, Bell, Lachlan, Curtis, Stephen J., Curtis, Belinda L., Seavers, Aine, Bartlett, Rachael, Dowton, Mark, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Ooi, Lezanne and Sluyter, Ronald (2020) Pharmacological and genetic characterisation of the canine P2X4 receptor. British Journal of Pharmacology, 177 (12). pp. 2812-2829. ISSN 0007-1188

Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138, Bibič, Lučka and Allum, Elizabeth (2020) To inhibit or enhance? Is there a benefit to positive allosteric modulation of P2X receptors? Frontiers in Pharmacology, 11. ISSN 1663-9812

Zusso, Morena, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Moro, Stefano and Giusti, Pietro (2020) Neuroinflammation and its resolution: From molecular mechanisms to therapeutic perspectives. Frontiers in Pharmacology, 11. ISSN 1663-9812

Skarratt, Kristen K., Gu, Ben J., Lovelace, Michael D., Milligan, Carol J., Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Glover, Rachel, Petrou, Steven, Wiley, James S. and Fuller, Stephen J. (2020) A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function. The FASEB Journal, 34 (3). pp. 3884-3901. ISSN 0892-6638

Sophocleous, R. A., Sluyter, V., Curtis, B. L., Curtis, S. J., Jurak, L. M., Faulks, M., Spildrejorde, M., Gates, S., Proctor, E. J., Seavers, A., Watson, D., Kuit, T., Dowton, M., Stokes, L. ORCID: https://orcid.org/0000-0003-4013-6781 and Sluyter, R. (2020) Association of a P2RX7 gene missense variant with brachycephalic dog breeds. Animal Genetics, 51 (1). pp. 127-131. ISSN 0268-9146

Akbar, Mohammad, Lukasewicz Ferreira, Pamela, Giorgetti, Melania, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 and Morris, Christopher ORCID: https://orcid.org/0000-0002-7703-4474 (2019) Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells. Beilstein journal of Nanotechnology, 10. 2553–2562. ISSN 2190-4286

Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2019) Recording P2X Receptors Using Whole-Cell Patch Clamp from Native Monocytes and Macrophages. In: Purinergic Signaling. Purinergic Signaling . Springer (Humana Press), pp. 275-283. ISBN 978-1-4939-9716-9

Bibic, Lucka, Herzig, Volker, King, Glenn and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2019) Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venoms. Journal of Natural Products, 82 (9). pp. 2559-2567. ISSN 0163-3864

Bidula, S. ORCID: https://orcid.org/0000-0002-3790-7138, Dhuna, K., Helliwell, R., Stebbing, M. and Stokes, L. ORCID: https://orcid.org/0000-0003-4013-6781 (2019) Herbaceous homicide:The Panax ginseng metabolite compound K accelerates caspase-3/7 activation and enhances macrophage cell death in a P2X7-dependent manner. British Journal of Pharmacology, 176 (16). p. 3028. ISSN 0007-1188

Bibic, Lucka, Druskis, Justinas, Walpole, Samuel, Angulo Alvarez, Jesus ORCID: https://orcid.org/0000-0001-7250-5639 and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2019) Bug off pain: An educational virtual reality game on spider venoms and chronic pain for public engagement. Journal of Chemical Education, 96 (7). pp. 1486-1490. ISSN 0021-9584

Bidula, Stefan M. ORCID: https://orcid.org/0000-0002-3790-7138, Cromer, Brett A., Walpole, Samuel, Angulo, Jesus ORCID: https://orcid.org/0000-0001-7250-5639 and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2019) Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7. Scientific Reports, 9. ISSN 2045-2322

Dhuna, Kshitija, Felgate, Matthew, Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138, Walpole, Samuel, Bibic, Lucka, Cromer, Brett, Angulo, Jesus ORCID: https://orcid.org/0000-0001-7250-5639, Sanderson, Julie, Stebbing, Martin and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2019) Ginsenosides act as positive modulators of P2X4 receptors. Molecular Pharmacology, 95 (2). pp. 210-221. ISSN 0026-895X

Bidula, Stefan ORCID: https://orcid.org/0000-0002-3790-7138, Dhuna, Kshitija, Helliwell, Ray and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2019) Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages. Cell Death & Disease, 10. ISSN 2041-4889

Al-Ansari, Farah, Lahooti, Hooshang, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Edirimanne, Senarath and Wall, Jack (2018) Correlation between thyroidal and peripheral blood total T cells, CD8+ T cells, and CD8+ T- regulatory cells and T-cell reactivity to calsequestrin and collagen XIII in patients with Graves’ ophthalmopathy. Endocrine Research, 43 (4). pp. 264-274. ISSN 0743-5800

Mills, Shirley, Howell, Lesley, Beekman, Andrew ORCID: https://orcid.org/0000-0002-3056-6406, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 and Mueller, Anja ORCID: https://orcid.org/0000-0003-0774-0434 (2018) Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4. Cellular Signalling, 42. 88–96. ISSN 0898-6568

Wilkinson, Shane M, Barron, Melissa L, O'Brien-Brown, James, Janssen, Bieneke, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Werry, Eryn L., Chishty, Mansoor, Skarratt, Kristen K., Ong, Jennifer A., Hibbs, David E., Vugts, Danielle J., Fuller, Stephen, Windhorst, Albert D. and Kassiou, Michael (2017) Pharmacological evaluation of novel bioisosteres of an adamantanyl benzamide P2X7 receptor antagonist. ACS Chemical Neuroscience, 8 (11). 2374–2380. ISSN 1948-7193

De Luca, Simone N., Ziko, Ilvana, Dhuna, Kshitija, Sominsky, Luba, Tolcos, Mary, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 and Spencer, Sarah J. (2017) Neonatal overfeeding by small-litter rearing sensitises hippocampal microglial responses to immune challenge: Reversal with neonatal repeated injections of saline or minocycline. Journal of Neuroendocrinology, 29 (11). ISSN 0953-8194

Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Layhadi, Janice A., Bibic, Lucka, Dhuna, Kshitija and Fountain, Samuel J. ORCID: https://orcid.org/0000-0002-6028-0548 (2017) P2X4 receptor function in the nervous system and current breakthroughs in pharmacology. Frontiers in Pharmacology, 8. ISSN 1663-9812

Gilbert, Daniel F., Stebbing, Martin J., Kuenzel, Katharina, Murphy, Robyn M., Zacharewicz, Evelyn, Buttgereit, Andreas, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Adams, David J. and Friedrich, Oliver (2016) Store-operated Ca2+ entry (SOCE) and purinergic receptor-mediated Ca2+ homeostasis in murine bv2 microglia cells: Early cellular responses to ATP-mediated microglia activation. Frontiers in Molecular Neuroscience, 9. ISSN 1662-5099

Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Mackenzie, Amanda and Sluyter, Ronald (2016) Roles of ion channels in immune cells. Frontiers in Immunology, 48. ISSN 1664-3224

Dao-Ung, Phuong, Skarratt, Kristen, Fuller, Stephen and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2015) Paroxetine suppresses recombinant human P2X7 responses. Purinergic Signalling, 11 (4). pp. 481-490. ISSN 1573-9538

Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Spencer, Sarah J. and Jenkins, Trisha A. (2015) Understanding the role of P2X7 in affective disorders—are glial cells the major players? Frontiers in Cellular Neuroscience, 9. ISSN 1662-5102

Helliwell, Ray, ShioukHuey, Charlene, Dhuna, Kshitija, Molero, Juan, Ye, Jiming, Xue, Charlie and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2015) Selected ginsenosides of the prptopanaxdiol series are novel positive allosteric modulators of P2X7 receptors. British Journal of Pharmacology, 172 (13). pp. 3326-3340. ISSN 0007-1188

Ziko, Ilvana, De Luca, Simone N, Dinan, Tara, Barwood, Joanne M, Sominsky, Luba, Cai, Guohui, Kenny, Rachel, Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781, Jenkins, Trisha A. and Spencer, Sarah J. (2014) Neonatal overfeeding alters hypothalamic microglial profiles and central responses to immune challenge long-term. Brain, Behavior, and Immunity, 41. pp. 32-43. ISSN 0889-1591

Higgins, K. R., Kovacevic, W. and Stokes, L. ORCID: https://orcid.org/0000-0003-4013-6781 (2014) Nucleotides regulate secretion of the inflammatory chemokine CCL2 from human macrophages and monocytes. Mediators of Inflammation, 2014. ISSN 0962-9351

Bhaskaracharya, Archana, Dao-Ung, Phuong, Jalilian, Iman, Spildrejorde, Mari, Skarratt, Kristen K., Fuller, Stephen J., Sluyter, Ronald and Stokes, Leanne ORCID: https://orcid.org/0000-0003-4013-6781 (2014) Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. PLoS One, 9 (3). ISSN 1932-6203