False positives associated with responder/non-responder analyses based on motor evoked potentials

van de Ruit, Mark and Grey, Michael J. (2019) False positives associated with responder/non-responder analyses based on motor evoked potentials. Brain Stimulation, 12 (2). pp. 314-318. ISSN 1935-861X

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Abstract

Background: A trend in the non-invasive brain stimulation literature is to assess the outcome of an intervention using a responder analysis whereby participants are di- or trichotomised in order that they may be classified as either responders or non-responders. Objective: Examine the extent of the Type I error in motor evoked potential (MEP) data subjected to responder analyses. Methods: Seven sets of 30 MEPs were recorded from the first dorsal interosseous muscle in 52 healthy volunteers. Four classification techniques were used to classify the participants as responders or non-responders: (1) the two-step cluster analysis, (2) dichotomised thresholding, (3) relative method and (4) baseline variance method. Results: Despite the lack of any intervention, a significant number of participants were classified as responders (21–71%). Conclusion: This study highlights the very large Type I error associated with dichotomising continuous variables such as the TMS MEP.

Item Type: Article
Uncontrolled Keywords: variability,mep,tms,plasticity,corticospinal excitability,responders
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 04 Dec 2018 09:30
Last Modified: 21 May 2020 00:10
URI: https://ueaeprints.uea.ac.uk/id/eprint/69158
DOI: 10.1016/j.brs.2018.11.015

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