False positives associated with responder/non-responder analyses based on motor evoked potentials

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van de Ruit, Mark and Grey, Michael J. ORCID: https://orcid.org/0000-0002-3216-3272 (2019) False positives associated with responder/non-responder analyses based on motor evoked potentials. Brain Stimulation, 12 (2). pp. 314-318. ISSN 1935-861X

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Abstract

Background: A trend in the non-invasive brain stimulation literature is to assess the outcome of an intervention using a responder analysis whereby participants are di- or trichotomised in order that they may be classified as either responders or non-responders. Objective: Examine the extent of the Type I error in motor evoked potential (MEP) data subjected to responder analyses. Methods: Seven sets of 30 MEPs were recorded from the first dorsal interosseous muscle in 52 healthy volunteers. Four classification techniques were used to classify the participants as responders or non-responders: (1) the two-step cluster analysis, (2) dichotomised thresholding, (3) relative method and (4) baseline variance method. Results: Despite the lack of any intervention, a significant number of participants were classified as responders (21–71%). Conclusion: This study highlights the very large Type I error associated with dichotomising continuous variables such as the TMS MEP.

Item Type:	Article
Uncontrolled Keywords:	variability,mep,tms,plasticity,corticospinal excitability,responders
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Rehabilitation
Related URLs:	http://www.scopus.com/inward/record.url?... https://linkinghub.elsevier.com/retrieve...
Depositing User:	LivePure Connector
Date Deposited:	04 Dec 2018 09:30
Last Modified:	13 May 2023 00:44
URI:	https://ueaeprints.uea.ac.uk/id/eprint/69158
DOI:	10.1016/j.brs.2018.11.015

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