Items where Research Group is "Synthetic and Medicinal Chemistry

A

Ahmadipour, Sanaz, Pergolizzi, Giulia, Rejzek, Martin, Field, Robert A. and Miller, Gavin J. (2019) Chemoenzymatic Synthesis of C6-Modified Sugar Nucleotides to Probe the GDP- d -Mannose Dehydrogenase from Pseudomonas aeruginosa. Organic Letters, 21 (12). pp. 4415-4419. ISSN 1523-7060

Arbach, Miriam, Santana, Taris M., Moxham, Hazel, Tinson, Ryan, Anwar, Awais, Groom, Murree and Hamilton, Christopher (2019) Antimicrobial garlic-derived diallyl polysulfanes: Interactions with biological thiols in Bacillus subtilis. Biochimica Et Biophysica Acta-General Subjects, 1863 (6). pp. 1050-1058. ISSN 0304-4165

B

Beekman, Andrew, Cominetti, Marco, Cartwright, Oliver, Boger, Dale L. and Searcey, Mark (2019) A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase. MedChemComm, 10 (12). pp. 2170-2174. ISSN 2040-2503

Beekman, Andrew, Cominetti, Marco M D and Searcey, Mark (2019) Duocarmycins as Antibody–Drug Conjugate (ADC) Payloads. In: Cytotoxic Payloads for Antibody-Drug Conjugates. Royal Society of Chemistry. ISBN 978-1-78801-077-1

Beekman, Andrew M., Cominetti, Marco M. D., Walpole, Samuel J., Prabhu, Saurabh, O'Connell, Maria A., Angulo Alvarez, Jesus and Searcey, Mark (2019) Identification of selective protein-protein interaction inhibitors using efficient in silico peptide-directed ligand design. Chemical Science, 10 (16). pp. 4502-4508. ISSN 2041-6520

Beswick, Laura, Ahmadipour, Sanaz, Dolan, Jonathan P., Rejzek, Martin, Field, Robert A. and Miller, Gavin J. (2019) Chemical and enzymatic synthesis of the alginate sugar nucleotide building block:GDP-D-mannuronic acid. Carbohydrate Research, 485. ISSN 0008-6215

Bew, Sean P., Coles, Simon J., Pitak, Mateusz B., Klooster, Wim T., Ashford, Polly-Anna and Zdorichenko, Victor (2019) Generating cis-aza-diaryl and triaryl ethers via organoBrønsted acid catalysed aza-Darzens chemistry. Tetrahedron, 75 (42). ISSN 0040-4020

Bressan, Giovanni, Cammidge, Andrew, Jones, Garth, Heisler, Ismael, Gonzalez-Lucas, Daniel, Remiro Buenamanana, Sonia and Meech, Stephen (2019) Electronic energy transfer in a subphthalocyanine – Zn porphyrin dimer studied by linear and nonlinear ultrafast spectroscopy. Journal of Physical Chemistry A, 123 (27). pp. 5724-5733. ISSN 0022-3654

Bridge, Thomas, Shaikh, Saher A., Thomas, Paul, Botta, Joaquin, McCormick, Peter J. and Sachdeva, Amit (2019) Site‐specific encoding of photoactivity in antibodies enables light‐mediated antibody‐antigen binding on live cells. Angewandte Chemie, 58 (50). pp. 17986-17993. ISSN 0044-8249

C

Charoenwongpaiboon, Thanapon, Klaewkla, Methus, Chunsrivirot, Surasak, Wangpaiboon, Karan, Pichyangkura, Rath, Field, Robert A. and Prousoontorn, Manchumas Hengsakul (2019) Rational re-design of Lactobacillus reuteri 121 inulosucrase for product chain length control. RSC Advances, 9 (26). pp. 14957-14965. ISSN 2046-2069

Charoenwongpaiboon, Thanapon, Pichyangkura, Rath, Field, Robert A. and Prousoontorn, Manchumas Hengsakul (2019) Preparation of cross-linked enzyme aggregates (CLEAs) of an inulosucrase mutant for the enzymatic synthesis of inulin-type fructooligosaccharides. Catalysts, 9 (8). ISSN 2073-4344

Charoenwongpaiboon, Thanapon, Wangpaiboon, Karan, Panpetch, Pawinee, Field, Robert A., Barclay, J. Elaine, Pichyangkura, Rath and Kuttiyawong, Kamontip (2019) Temperature-dependent inulin nanoparticles synthesized by Lactobacillus reuteri 121 inulosucrase and complex formation with flavonoids. Carbohydrate Polymers, 223. ISSN 0144-8617

Chi, Bui Khanh, Huyen, Nguyen Thi Thu, Loi, Vu Van, Gruhlke, Martin, Schaffer, Marc, Mäder, Ulrike, Maaß, Sandra, Becher, Dorte, Bernhardt, Jorg, Arbach, Miriam, Hamilton, Chris J., Slusarenko, Alan J. and Antelmann, Haike (2019) The disulfide stress response and protein S-thioallylation caused by allicin and diallyl polysulfanes in Bacillus subtilis as revealed by transcriptomics and proteomics. Antioxidants, 8 (12). ISSN 2076-3921

D

Dou, Wei Tao, Liu, Li Fang, Gao, Jie, Zang, Yi, Chen, Guo Rong, Field, Robert A., James, Tony D., Li, Jia and He, Xiao Peng (2019) Fluorescence imaging of a potential diagnostic biomarker for breast cancer cells using a peptide-functionalized fluorogenic 2D material. Chemical Communications, 55 (88). pp. 13235-13238. ISSN 1359-7345

E

Emmrich, Peter M.F., Rejzek, Martin, Hill, Lionel, Brett, Paul, Edwards, Anne, Sarkar, Abhimanyu, Field, Rob A., Martin, Cathie and Wang, Trevor L. (2019) Linking a rapid throughput plate-assay with high-sensitivity stable-isotope label LCMS quantification permits the identification and characterisation of low β-L-ODAP grass pea lines. BMC Plant Biology, 19 (1). ISSN 1471-2229

H

He, Xiao Peng, Zhang, Chao, Wang, Guanzhen, Han, Hai Hao, Hu, Xi Le, Field, Rob, Chen, Guo Rong, Li, Jia, Ye, Bing and Zang, Yi (2019) Self-assembled thin-layer glycomaterials with an appropriate shell thickness for targeted and activatable cell imaging. Frontiers in Chemistry, 7 (APR). ISSN 2296-2646

Hodgson, Hannah, De La Peña, Ricardo, Stephenson, Michael J., Thimmappa, Ramesh, Vincent, Jason L., Sattely, Elizabeth S. and Osbourn, Anne (2019) Identification of key enzymes responsible for protolimonoid biosynthesis in plants: Opening the door to azadirachtin production. Proceedings of the National Academy of Sciences, 116 (34). pp. 17096-17104. ISSN 0027-8424

Hu, Xi Le, Cai, Quanyu, Gao, Jie, Field, Robert A., Chen, Guo Rong, Jia, Ningyang, Zang, Yi, Li, Jia and He, Xiao Peng (2019) Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells. ACS Applied Materials and Interfaces, 11 (25). pp. 22181-22187. ISSN 1944-8244

J

Jiménez Tejada, Juan A., Romero, Adrian, Gonzalez, Jesus, Chaure, Nandu B., Cammidge, Andy, Chambrier, Isabelle, Ray, Asim K. and Deen, M. Jamal (2019) Evolutionary computation for parameter extraction of organic thin film transistors using newly synthesized liquid crystalline nickel phthalocyanine. Micromachines, 10 (10). ISSN 2072-666X

K

Kay, Kristine L., Hamilton, Chris J. and Le Brun, Nick E. (2019) Mass spectrometric studies of Cu(I)-binding to the N-terminal domains of B. subtilis CopA and influence of bacillithiol. Journal of Inorganic Biochemistry, 190. pp. 24-30. ISSN 0162-0134

Khozaee, Zahra, Chambrier, Isabelle, Sosa Vargas, Lydia, Cammidge, Andy and Ray, Asim (2019) Impedance spectroscopic study on hybrid phthalocyanine/lead sulfide nanocomposite film. Journal of Porphyrins and Phthalocyanines, 23 (11). pp. 1622-1628. ISSN 1088-4246

Kuhaudomlarp, Sakonwan, Pergolizzi, Giulia, Patron, Nicola J., Henrissat, Bernard and Field, Robert A. (2019) Unraveling the subtleties of β-(1→3)-glucan phosphorylase specificity in the GH94, GH149, and GH161 glycoside hydrolase families. Journal of Biological Chemistry, 294 (16). pp. 6483-6493. ISSN 0021-9258

Kuhaudomlarp, Sakonwan, Stevenson, Clare E.M., Lawson, David M. and Field, Robert A. (2019) The structure of a GH149 β-(1 → 3) glucan phosphorylase reveals a new surface oligosaccharide binding site and additional domains that are absent in the disaccharide-specific GH94 glucose-β-(1 → 3)-glucose (laminaribiose) phosphorylase. Proteins: Structure, Function and Bioinformatics, 87 (10). pp. 885-892. ISSN 0887-3585

Kuhaudomlarp, Sakonwan, Walpole, Samuel, Stevenson, Clare E. M., Nepogodiev, Sergey A., Lawson, David M., Angulo, Jesus and Field, Robert A. (2019) Unravelling the specificity of laminaribiose phosphorylase from Paenibacillus sp. YM‐1 towards donor substrates glucose/mannose 1-phosphate by using X‐ray crystallography and saturation transfer difference NMR spectroscopy. ChemBioChem, 20 (2). pp. 181-192. ISSN 1439-4227

L

Labourel, Aurore, Baslé, Arnaud, Munoz-Munoz, Jose, Ndeh, Didier, Booth, Simon, Nepogodiev, Sergey A., Field, Robert A. and Cartmell, Alan (2019) Structural and functional analyses of glycoside hydrolase 138 enzymes targeting chain A galacturonic acid in the complex pectin rhamnogalacturonan II. Journal of Biological Chemistry, 294 (19). pp. 7711-7721. ISSN 0021-9258

Latousakis, Dimitrios, Nepravishta, Ridvan, Rejzek, Martin, Wegmann, Udo, Le Gall, Gwenaelle, Kavanaugh, Devon, Colquhoun, Ian, Frese, Steven, MacKenzie, Donald, Walter, Jens, Angulo, Jesus, Field, Rob and Juge, Nathalie (2019) Serine-rich repeat protein adhesins from Lactobacillus reuteri display strain specific glycosylation profiles. Glycobiology, 29 (1). pp. 45-58. ISSN 0959-6658

Leveau, Aymeric, Reed, James, Qiao, Xue, Stephenson, Michael J., Mugford, Sam T., Melton, Rachel E., Rant, Jenni C., Vickerstaff, Robert, Langdon, Tim and Osbourn, Anne (2019) Towards take-all control: a C-21β oxidase required for acylation of triterpene defence compounds in oat. New Phytologist, 221 (3). pp. 1544-1555. ISSN 0028-646X

Linzner, Nico, Loi, Vu Van, Fritsch, Verena Nadin, Tung, Quach Ngoc, Stenzel, Saskia, Wirtz, Markus, Hell, Rüdiger, Hamilton, Chris J., Tedin, Karsten, Fulde, Marcus and Antelmann, Haike (2019) Staphylococcus aureus uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide reductase (YpdA) redox pathway to defend against oxidative stress under infections. Frontiers in Microbiology, 10. ISSN 1664-302X

O

Orme, Anastasia, Louveau, Thomas, Stephenson, Michael J., Appelhagen, Ingo, Melton, Rachel, Cheema, Jitender, Li, Yan, Zhao, Qiang, Zhang, Lei, Fan, Danlin, Tian, Qilin, Vickerstaff, Robert J., Langdon, Tim, Han, Bin and Osbourn, Anne (2019) A noncanonical vacuolar sugar transferase required for biosynthesis of antimicrobial defense compounds in oat. Proceedings of the National Academy of Sciences of the United States of America, 116 (52). pp. 27105-27114. ISSN 0027-8424

P

Pal, Chandana, Chambrier, Isabelle, Cammidge, Andy, Sharma, A. K. and Ray, Asim (2019) Steady state charge conduction through solution processed liquid crystalline lanthanide bisphthalocyanine films. Journal of Porphyrins and Phthalocyanines, 23 (11). pp. 1603-1615. ISSN 1088-4246

Polsinelli, Ivan, Caliandro, Rosanna, Salomone-Stagni, Marco, Demitri, Nicola, Rejzek, Martin, Field, Robert A. and Benini, Stefano (2019) Comparison of the Levansucrase from the epiphyte Erwinia tasmaniensis vs its homologue from the phytopathogen Erwinia amylovora. International Journal of Biological Macromolecules, 127. pp. 496-501. ISSN 0141-8130

S

Stephenson, M.J., Field, R.A. and Osbourn, A. (2019) The protosteryl and dammarenyl cation dichotomy in polycyclic triterpene biosynthesis revisited: Has this 'rule' finally been broken? Natural Product Reports, 36. pp. 1044-1052. ISSN 0265-0568

W

Wagstaff, Ben A., Rejzek, Martin, Kuhaudomlarp, Sakonwan, Hill, Lionel, Mascia, Ilaria, Nepogodiev, Sergey A., Dorfmueller, Helge C. and Field, Robert A. (2019) Discovery of an RmlC/D fusion protein in the microalga Prymnesium parvum and its implications for NDP-L-rhamnose biosynthesis in microalgae. Journal of Biological Chemistry, 294 (23). pp. 9172-9185. ISSN 0021-9258

Wangpaiboon, Karan, Pitakchatwong, Chutamart, Panpetch, Pawinee, Charoenwongpaiboon, Thanapon, Field, Robert A. and Pichyangkura, Rath (2019) Modified properties of alternan polymers arising from deletion of SH3-like motifs in Leuconostoc citreum ABK-1 alternansucrase. Carbohydrate Polymers, 220. pp. 103-109. ISSN 0144-8617

Z

Zhang, Hanyan, Sun, Dandan, Wang, Guanzhen, Cui, Shichao, Field, Robert A., Li, Jia and Zang, Yi (2019) Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell. Biochemical and Biophysical Research Communications, 511 (2). pp. 387-393. ISSN 0006-291X