Items where Research Group is "Cancer Studies

Abdulla, S, Saada, J, Johnson, G, Jefferies, S and Ajithkumar, T (2015) Tumour progression or pseudoprogression?:A review of post-treatment radiological appearances of glioblastoma. Clinical Radiology, 70 (11). pp. 1299-1312. ISSN 0009-9260

Alshaker, Heba, Krell, Jonathan, Frampton, Adam E., Wang, Qi, Cooper, Colin ORCID: https://orcid.org/0000-0003-2013-8042, Winkler, Mathias, Yaguee, Ernesto, Pchejetski, Dmitri and Alshaker, Heba (2015) Leptin receptor-dependent and -independent STAT3 phosphorylation in oestrogen receptor-negative breast cancer. International Journal of Molecular Medicine, 36. S6. ISSN 1107-3756

Alshaker, Heba, Wang, Qi, Frampton, Adam E., Krell, Jonathan, Waxman, Jonathan, Winkler, Mathias, Stebbing, Justin, Cooper, Colin ORCID: https://orcid.org/0000-0003-2013-8042, Yaguee, Ernesto and Pchejetski, Dmitri (2015) Sphingosine kinase 1 contributes to leptin-induced STAT3 phosphorylation through IL-6/gp130 transactivation in oestrogen receptor-negative breast cancer. Breast Cancer Research and Treatment, 149 (1). pp. 59-67. ISSN 1573-7217

Bettencourt-Silva, Joao H., Clark, Jeremy, Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042, Mills, Robert, Rayward-Smith, Victor J. and De La Iglesia, Beatriz ORCID: https://orcid.org/0000-0003-2675-5826 (2015) Building data-driven pathways from routinely collected hospital data: A case study on prostate cancer. JMIR Medical Informatics, 3 (3). ISSN 2291-9694

Boutros, Paul C., Fraser, Michael, Harding, Nicholas J., De Borja, Richard, Trudel, Dominique, Lalonde, Emilie, Meng, Alice, Hennings-Yeomans, Pablo H., McPherson, Andrew, Sabelnykova, Veronica Y., Zia, Amin, Fox, Natalie S., Livingstone, Julie, Shiah, Yu-jia, Wang, Jianxin, Beck, Timothy A., Have, Cherry L., Chong, Taryne, Sam, Michelle, Johns, Jeremy, Timms, Lee, Buchner, Nicholas, Wong, Ada, Watson, John D., Simmons, Trent T., P'ng, Christine, Zafarana, Gaetano, Nguyen, Francis, Luo, Xuemei, Chu, Kenneth C., Prokopec, Stephenie D., Sykes, Jenna, Dal Pra, Alan, Berlin, Alejandro, Brown, Andrew, Chan-seng-yue, Michelle A., Yousif, Fouad, Denroche, Robert E., Chong, Lauren C., Chen, Gregory M., Jung, Esther, Fung, Clement, Starmans, Maud H. W., Chen, Hanbo, Govind, Shaylan K., Hawley, James, D'Costa, Alister, Pintilie, Melania, Waggott, Daryl, Hach, Faraz, Lambin, Philippe, Muthuswamy, Lakshmi B., Cooper, Colin ORCID: https://orcid.org/0000-0003-2013-8042, Eeles, Rosalind, Neal, David, Tetu, Bernard, Sahinalp, Cenk, Stein, Lincoln D., Fleshner, Neil, Shah, Sohrab P., Collins, Colin C., Hudson, Thomas J., Mcpherson, John D., van der Kwast, Theodorus and Bristow, Robert G. (2015) Spatial genomic heterogeneity within localized, multifocal prostate cancer. Nature Genetics, 47 (7). 736–745. ISSN 1061-4036

Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042, Eeles, Rosalind A., Wedge, David C., Van Loo, Peter, Gundem, Gunes, Alexandrov, Ludmil B., Kreymer, Barbara, Butler, Adam, Lynch, Andrew, Edwards, Sandra E., Camacho, Niedzica, Massie, Charlie E., Kote-Jarai, Zsofia, Dennis, Nening, Merson, Sue, Leongamornlert, Daniel A., Zamora, Jorge, Kay, Jonathan, Luxton, Hayley J., Corbishley, Cathy, Thomas, Sarah, Nik-Zainal, Serena, Ramakrishna, Manasa, O'Meara, Sarah, Matthews, Lucy, Clark, Jeremy, Hurst, Rachel, Mithen, Richard, Bristow, Robert G., Boutros, Paul C., Fraser, Michael, Cooke, Susanna, Raine, Keiran, Jones, David, Menzies, Andrew, Stebbings, Lucy, Hinton, Jon, Teague, Jon, McLaren, Stuart, Mudie, Laura, Hardy, Claire, Anderson, Elizabeth, Joseph, Olivia, Goody, Victoria, Robinson, Ben, Maddison, Mark, Gamble, Stephen J., Greenman, Christopher, Berney, Dan, Hazell, Steven, Livni, Naomi, Fisher, Cyril, Ogden, Christopher, Kumar, Pardeep, Thompson, Alan, Woodhouse, Christopher J., Nicol, David, Mayer, Erik, Dudderidge, Tim, Shah, Nimish, Gnanapragasam, Vincent, Voet, Thierry, Campbell, Peter, Futreal, P. Andrew, Easton, Douglas F., Warren, Anne Y., Foster, Christopher S., Stratton, Michael R., Whitaker, Hayley C., McDermott, Ultan, Brewer, Daniel S. ORCID: https://orcid.org/0000-0003-4753-9794 and Neal, David E. and the ICGC Prostate Group (2015) Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nature Genetics, 47. 367–372. ISSN 1061-4036

Decock, Julie, Hendrickx, Wouter, Thirkettle, Sally, Gutiérrez-Fernández, Ana, Robinson, Stephen D ORCID: https://orcid.org/0000-0002-6606-7588 and Edwards, Dylan R ORCID: https://orcid.org/0000-0002-3292-2064 (2015) Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice. Breast Cancer Research, 17 (1). ISSN 1465-542X

El-Shater Bosaily, A., Parker, C., Brown, L. C., Gabe, R., Hindley, R. G., Kaplan, R., Emberton, M. and Ahmed, H. U. and on behalf of the PROMIS Group (2015) PROMIS - Prostate MR imaging study:A paired validating cohort study evaluating the role of multi-parametric MRI in men with clinical suspicion of prostate cancer. Contemporary Clinical Trials, 42. pp. 26-40. ISSN 1551-7144

Ellison, Tim S., Atkinson, Samuel J., Steri, Veronica, Kirkup, Benjamin M., Preedy, Michael E. J., Johnson, Robert T., Ruhrberg, Christiana, Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064, Schneider, Jochen G., Weilbaecher, Katherine and Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588 (2015) Suppression of β3-integrin in mice triggers a neuropilin-1- dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Disease Models & Mechanisms, 8. pp. 1105-1119. ISSN 1754-8403

Gilani, Nima, Rosenkrantz, Andrew B., Malcolm, Paul and Johnson, Glyn (2015) Minimisation of errors in biexponential T2 measurements of the prostate. Journal of Magnetic Resonance Imaging, 42 (4). pp. 1072-1077. ISSN 1522-2586

Gundem, Gunes, Van Loo, Peter, Kremeyer, Barbara, Alexandrov, Ludmil B., Tubio, Jose M. C., Papaemmanuil, Elli, Brewer, Daniel ORCID: https://orcid.org/0000-0003-4753-9794, Kallio, Heini, Högnäs, Högnäs, Annala, Matti, Kivinummi, Kati, Goody, Victoria, Latimer, Calli, O'Meara, Sarah, Dawson, Kevin, Isaacs, William, Emmert-Buck, Michael R., Nykter, Matti, Foster, Christopher S., Kote-Jarai, Zsofia, Easton, Douglas F., Whitaker, Hayley C., Neal, David E., Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042, Eeles, Rosalind A., Visakorpi, Tapio, Campbell, Peter, McDermott, Ultan, Wedge, David C. and Bova, G. Steven and ICGC Prostate UK Group* (2015) The evolutionary history of lethal metastatic prostate cancer. Nature, 520 (7547). 353–357. ISSN 1476-4687

Ibrahim, Therese, Few, Karen, Greenwood, Richard, Smith, Cheryl, Malcolm, Paul, Johnson, Glyn, Lally, Pete, Thayyil, Sudhin and Clarke, Paul ORCID: https://orcid.org/0000-0001-6203-7632 (2015) 'Feed and wrap' or sedate and immobilise for neonatal brain MRI? Archives of Disease in Childhood: Fetal & Neonatal Edition, 100 (5). ISSN 1359-2998

Jennings, Barbara ORCID: https://orcid.org/0000-0003-3792-9182 and Willis, Gavin (2015) How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy. Cancer Letters, 356 (2 Part A). pp. 224-230. ISSN 1872-7980

Jennings, Barbara A. ORCID: https://orcid.org/0000-0003-3792-9182, Shakespeare, Tom and Loke, Yoon K. (2015) Scanning the human genome and the horizon: the potential and pitfalls of pharmacogenetics and stratified medicine. British Journal of General Practice, 65 (653). 284 -285. ISSN 0960-1643

Ju, Young Seok, Tubio, Jose M. C., Mifsud, William, Fu, Beiyuan, Davies, Helen R., Ramakrishna, Manasa, Li, Yilong, Yates, Lucy, Gundem, Gunes, Tarpey, Patrick S., Behjati, Sam, Papaemmanuil, Elli, Martin, Sancha, Fullam, Anthony, Gerstung, Moritz, Nangalia, Jyoti, Green, Anthony R., Caldas, Carlos, Borg, Åke, Tutt, Andrew, Lee, Ming Ta Michael, van'T Veer, Laura J., Tan, Benita K. T., Aparicio, Samuel, Span, Paul N., Martens, John W. M., Knappskog, Stian, Vincent-Salomon, Anne, Børresen-Dale, Anne-Lise, Eyfjörd, Jórunn Erla, Myklebost, Ola, Flanagan, Adrienne M., Foster, Christopher, Neal, David E., Cooper, Colin ORCID: https://orcid.org/0000-0003-2013-8042, Eeles, Rosalind, Bova, G. Steven, Lakhani, Sunil R., Desmedt, Christine, Thomas, Gilles, Richardson, Andrea L., Purdie, Colin A., Thompson, Alastair M., McDermott, Ultan, Yang, Fengtang, Nik-Zainal, Serena, Campbell, Peter J. and Stratton, Michael R. and ICGC Prostate Cancer Working Group, ICGC Bone Cancer Working Group, ICGC Breast Cancer Working Group (2015) Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells. Genome Research, 25 (6). pp. 814-824. ISSN 1088-9051

Kelwick, Richard, Desanlis, Ines, Wheeler, Grant N ORCID: https://orcid.org/0000-0002-4335-8577 and Edwards, Dylan R ORCID: https://orcid.org/0000-0002-3292-2064 (2015) The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family. Genome Biology, 16. ISSN 1465-6906

Kelwick, Richard, Wagstaff, Laura, Decock, Julie, Roghi, Christian, Cooley, Lindsay S., Robinson, Stephen D. ORCID: https://orcid.org/0000-0002-6606-7588, Arnold, Hugh, Gavrilovic, Jelena ORCID: https://orcid.org/0000-0002-5312-1784, Jaworski, Diane M., Yamamoto, Kazuhiro, Nagase, Hideaki, Seubert, Bastian, Krüger, Achim and Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 (2015) Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15. International Journal of Cancer, 136 (4). E14–E26. ISSN 0020-7136

Ma, Yingna, Gao, Weiqi, Wu, Kun and Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 (2015) Flavonoid intake and the risk of age-related cataract in China’s Heilongjiang Province. Food & Nutrition Research, 59. ISSN 1654-6628

Mannu, Gurdeep S., Macartney, Alistair, Lambert, Jonathan R. A., Bettencourt-silva, Joao H., Lawn, Mark, Lyall, Hamish, Metcalf, Anthony Kneale, Potter, John F., Wood, John, Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941, Baglin, Trevor, Myint, Phyo Kyaw and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2015) The clinical utility of Multiplate analyser measurement in platelet function testing following stroke and transient ischaemic attack. European Journal of Haematology, 94 (2). 138–144. ISSN 0902-4441

Manson-Bahr, David, Ball, Richard, Gundem, Gunes, Mills, Robert, Rochester, Mark, Goody, Victoria, O'Meara, Sarah, Flather, Marcus, Keeling, Matthew, Yazbek Hanna, Marcelino, Hurst, Rachel, Curley, Helen, Clark, Jeremy, Brewer, Daniel ORCID: https://orcid.org/0000-0003-4753-9794, Mcdermott, Ultan and Cooper, Colin ORCID: https://orcid.org/0000-0003-2013-8042 (2015) Mutation detection in formalin-fixed prostate cancer biopsies taken at the time of diagnosis using next generation DNA sequencing. Journal of Clinical Pathology, 68. pp. 212-217. ISSN 0021-9746

Massie, Charlie E., Spiteri, Inmaculada, Ross-Adams, Helen, Luxton, Hayley J., Kay, Jonathan, Whitaker, Hayley C., Dunning, Mark J., Lamb, Alastair D., Ramos-Montoya, Antonio, Brewer, Daniel ORCID: https://orcid.org/0000-0003-4753-9794, Cooper, Colin ORCID: https://orcid.org/0000-0003-2013-8042, Eeles, Rosalind A., Warren, Anne Y., Tavaré, Simon, Neal, David E. and Lynch, Andy G. (2015) HES5 silencing is an early and recurrent change in prostate tumourigenesis. Endocrine-Related Cancer (ERC), 22 (2). pp. 131-144. ISSN 1351-0088

Meulendijks, Didier, Henricks, Linda M., Sonke, Gabe S., Deenen, Maarten J., Froehlich, Tanja K., Amstutz, Ursula, Largiadèr, Carlo R., Jennings, Barbara A. ORCID: https://orcid.org/0000-0003-3792-9182, Marinaki, Anthony M., Sanderson, Jeremy D., Kleibl, Zdenek, Kleiblova, Petra, Schwab, Matthias, Zanger, Ulrich M., Palles, Claire, Tomlinson, Ian, Gross, Eva, van Kuilenburg, André B.P., Punt, Cornelis J.A., Koopman, Miriam, Beijnen, Jos H. and Cats, Annemieke (2015) Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity:A systematic review and meta-analysis of individual patient data. The Lancet Oncology, 16 (16). pp. 1639-1650. ISSN 1470-2045

Murray, Megan Y., Zaitseva, Lyubov, Auger, Martin J., Craig, Jenny I.O., MacEwan, David, Rushworth, Stuart A. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2015) Ibrutinib inhibits BTK-driven NF-κB p65 activity to overcome bortezomib-resistance in multiple myeloma. Cell Cycle, 14 (14). pp. 2367-2375. ISSN 1538-4101

Pillinger, Genevra, Abdul-Aziz, Amina, Zaitseva, Lyubov, Lawes, Matt, MacEwan, David, Bowles, Kristian ORCID: https://orcid.org/0000-0003-1334-4526 and Rushworth, Stuart (2015) Targeting BTK for the treatment of FLT3-ITD mutated acute myeloid leukemia. Scientific Reports, 5. ISSN 2045-2322

Ross-Adams, H., Lamb, A. D., Dunning, M. J., Halim, S., Lindberg, J., Massie, C. M., Egevad, L. A., Russell, R., Ramos-Montoya, A., Vowler, S. L., Sharma, N. L., Kay, J., Whitaker, H., Clark, J., Hurst, R., Gnanapragasam, V. J., Shah, N. C., Warren, A. Y., Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042, Lynch, A. G., Stark, R., Mills, I. G., Groenberg, H. and Neal, D. E. (2015) Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study. EBioMedicine, 2 (9). 1133–1144.

Rushworth, Stuart A., Pillinger, Genevra, Abdul-Aziz, Amina, Piddock, Rachel, Shafat, Manar S., Murray, Megan Y., Zaitseva, Lyubov, Lawes, Matthew J., MacEwan, David J. and Bowles, Kristian M. ORCID: https://orcid.org/0000-0003-1334-4526 (2015) Activity of Bruton's tyrosine-kinase inhibitor ibrutinib in patients with CD117-positive acute myeloid leukaemia: a mechanistic study using patient-derived blast cells. The Lancet Haematology, 2 (5). e204-e211.

Shah, N M, Zaitseva, L, Bowles, K M ORCID: https://orcid.org/0000-0003-1334-4526, Macewan, D J and Rushworth, S A (2015) NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival. Cell Death and Differentiation, 22. pp. 654-664. ISSN 1350-9047

Soiza, Roy L, Cumming, Kirsten, Clark, Allan B ORCID: https://orcid.org/0000-0003-2965-8941, Bettencourt-Silva, Joao H, Metcalfe, Anthony K, Bowles, Kristian M ORCID: https://orcid.org/0000-0003-1334-4526, Potter, John F and Myint, Phyo (2015) Hyponatremia predicts mortality after stroke. International Journal of Stroke, 10 (A100). pp. 50-55. ISSN 1747-4930

Wang, Wei, He, Yan, Yu, Guodong, Li, Baolong, Sexton, Darren W., Wileman, Thomas, Roberts, Alexandra A., Hamilton, Chris J., Liu, Ruoxi, Chao, Yimin ORCID: https://orcid.org/0000-0002-8488-2690, Shan, Yujuan and Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 (2015) Sulforaphane protects the liver against CdSe quantum dot-induced cytotoxicity. PLoS One, 10 (9). ISSN 1932-6203

Wang, Yichong, Dacosta, Christopher, Wang, Wei, Zhou, Zhigang, Liu, Chun-Ming and Bao, Yongping ORCID: https://orcid.org/0000-0002-6425-0370 (2015) Synergy between sulforaphane and selenium in protection against oxidative damage in colonic CCD841 cells. Nutrition Research, 35 (7). 610–617. ISSN 0271-5317

Wu, Ping, Walker, Brian A, Broyl, Annemiek, Kaiser, Martin, Johnson, David C, Kuiper, Rowan, van Duin, Mark, Gregory, Walter M, Davies, Faith E, Brewer, Daniel ORCID: https://orcid.org/0000-0003-4753-9794, Hose, Dirk, Sonneveld, Pieter and Morgan, Gareth J (2015) A gene expression based predictor for high risk myeloma treated with intensive therapy and autologous stem cell rescue. Leukemia & Lymphoma, 56 (3). pp. 594-601. ISSN 1042-8194