Tumour progression or pseudoprogression?:A review of post-treatment radiological appearances of glioblastoma

Abdulla, S, Saada, J, Johnson, G, Jefferies, S and Ajithkumar, T (2015) Tumour progression or pseudoprogression?:A review of post-treatment radiological appearances of glioblastoma. Clinical Radiology, 70 (11). pp. 1299-1312. ISSN 0009-9260

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Abstract

Glioblastoma (GBM) is a common brain tumour in adults, which, despite multimodality treatment, has a poor median survival. Efficacy of therapy is assessed by clinical examination and magnetic resonance imaging (MRI) features. There is now a recognised subset of treated patients with imaging features that indicate "progressive disease" according to Macdonald's criteria, but subsequently, show stabilisation or resolution without a change in treatment. In these cases of "pseudoprogression", it is believed that non-tumoural causes lead to increased contrast enhancement and conventional MRI is inadequate in distinguishing this from true tumour progression. Incorrect diagnosis is important, as failure to identify pseudoprogression could lead to an inappropriate change of effective therapy. The purpose of this review is to outline the current research into radiological assessment with MRI and molecular imaging of post-treatment GBMs, specifically the differentiation between pseudoprogression and tumour progression.

Item Type: Article
Additional Information: Copyright © 2015 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 19 Jan 2016 10:00
Last Modified: 22 Jul 2020 00:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/56645
DOI: 10.1016/j.crad.2015.06.096

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