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ToolsLi, Yixuan, Deng, Longji, Walker, Emma Jane Lougheed, Karas, Bogumil J. and Mock, Thomas (2025) Genetic engineering in diatoms: Advances and prospects. The Plant Journal, 121 (6). ISSN 0960-7412
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Abstract
Diatoms are among the most diverse and ecologically significant groups of photosynthetic microalgae, contributing over 20% of global primary productivity. Their ecological significance, unique biology, and genetic tractability make them ideal targets for genetic and genomic engineering and metabolic reprogramming. Over the past few decades, numerous genetic methods have been developed and applied to these organisms to better understand the function of individual genes and how they underpin diatom metabolism. Additionally, the ability of diatoms to synthesize diverse high-value metabolites and elaborate mineral structures offers significant potential for applications in biotechnology, including the synthesis of novel pharmaceuticals, nutraceuticals, and biomaterials. This review discusses the latest developments in diatom genetic engineering and provides prospects not only to promote the use of diatoms in diverse fields of biotechnology but also to deepen our understanding of their role in natural ecosystems.
| Item Type: | Article |
|---|---|
| Additional Information: | Data Availability Statement: The data of this study are available as part of the main article and the supplementary material. Funding information: China Scholarship Council. Grant Number: 202106330018; University of East Anglia; Natural Environment Research Council. Grant Number: NE/W005654/1; Natural Sciences and Engineering Research Council of Canada. Grant Number: RGPIN-2018-06172 |
| Uncontrolled Keywords: | diatoms,genetic engineering,metabolic engineering,synthetic biology,genetics,plant science,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1311 |
| Faculty \ School: | Faculty of Science > School of Environmental Sciences University of East Anglia Research Groups/Centres > Theme - ClimateUEA |
| UEA Research Groups: | Faculty of Science > Research Groups > Environmental Biology Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Mar 2025 17:30 |
| Last Modified: | 29 Apr 2025 15:33 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/98863 |
| DOI: | 10.1111/tpj.70102 |
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