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ToolsJatkowska, Aleksandra, Gkikas, Konstantinos, Nichols, Ben, Short, Bryn, Rizou, Vasiliki Konstantina, Kapranos, Panagiotis, Gunnewiek, Jennifer Klein, Christina, Edelyn, Svolos, Vaios, Quince, Christopher and Gerasimidis, Konstantinos (2024) Dose-dependent effects of enteral nutrition on the faecal microbiota and short chain fatty acids. Clinical Nutrition, 43 (5). pp. 1200-1207. ISSN 0261-5614
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Abstract
Introduction: Enteral nutrition (EN) involves replacing all or part of a person's habitual diet with a nutritional formula. The impact of varying doses of EN on the gut microbiome remains understudied. Methods: Healthy adults replaced all (100% EN) or part (85% EN, 50% EN and 20% EN) of their energy requirements with EN for 7 days. Faecal samples were collected before and on day 7 of interventions. Faecal pH, short chain fatty acids (SCFAs), branched-chain fatty acids (BCFAs) and 16S rRNA sequencing were performed. Dietary assessment was performed with 7-day food diaries. Results: Sixty-one participants (31 females; median (IQR) age: 24.7 (23.0–27.8) years) were recruited. A dose-dependent impact of EN on faecal microbiota, SCFAs, BCFAs) and pH was observed, with changes detectable at EN intakes of at least 50% of energy requirements. 100% and 85% EN reduced the abundance of fibre-fermenting taxa such as Agathobacter, Faecalibaterium, Succinivibrio and Acidaminococcus. In parallel, potentially harmful organisms like Eubacterium, Actinomyces, and Klebsiella increased. In the 50% EN group, adherence to a diet high in fish, vegetables, potatoes, non-alcoholic beverages, and fat spreads, and low in cereal products, milk, and meat negatively correlated with changes in microbiota structure (r = −0.75, P = 0.025). This signal was not observed when using compositional tools for microbiota analysis. Conclusions: EN detrimentally influences the faecal microbiota and diet-related bacterial metabolites in a dose-dependent manner, particularly at doses of at least 50%. The findings of this study have implications for the dietary management and counselling of patients receiving high volume EN.
| Item Type: | Article |
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| Additional Information: | Data availability statement: The raw sequencing data used for this project has been deposited in the European Nucleotide Archive (ENA) under accession number: PRJEB72881. Other datasets will be shared upon request. Funding Information: The studentships of AJ and KGk are funded by Nestle Health Science and the University of Glasgow . KGe received research funding, speakers fee and travel expenses covered by Nestle Health Science , Nutricia-Danone , AbbVie , Janssen , Abbott . VS received consultancy fees from Chronicles Health. The rest of the authors have no conflicts of interest to disclose. The funders had no role in the conception, design, execution, interpretation, writing or submission of this manuscript. |
| Uncontrolled Keywords: | crohn's disease,enteral nutrition,eosinophilic oesophagitis,gut microbiome,nutritional rehabilitation,nutrition and dietetics,critical care and intensive care medicine ,/dk/atira/pure/subjectarea/asjc/2900/2916 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 24 Oct 2024 12:30 |
| Last Modified: | 24 Oct 2024 12:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/97179 |
| DOI: | 10.1016/j.clnu.2024.04.010 |
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