The interaction of anhydroalditols with sweet-almond β-glucosidase and Escherichia coli β-galactosidase: Implications for the design of potent glycosidase inhibitors

Field, Robert A. ORCID: https://orcid.org/0000-0001-8574-0275, Haines, Alan H. and Chrystal, Ewan J. T. (1991) The interaction of anhydroalditols with sweet-almond β-glucosidase and Escherichia coli β-galactosidase: Implications for the design of potent glycosidase inhibitors. Bioorganic and Medicinal Chemistry Letters, 1 (12). pp. 667-672. ISSN 0960-894X

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Abstract

A range of 1,4- and 1,5-anhydroalditols have been synthesized and assessed for their ability to inhibit glycosidases. Observed inhibition indicates that aglycone-enzyme interactions contribute significantly to both the affinity and the stereoselectivity of substrate binding. Such interactions may also contribute to enzyme-transition state interactions. Implications for the design of potent glycosidase inhibitors are discussed.

Item Type:	Article
Additional Information:	Funding Information: Science and Engineering Research Council and
Uncontrolled Keywords:	biochemistry,molecular medicine,molecular biology,pharmaceutical science,drug discovery,clinical biochemistry,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Chemical Sciences and Pharmacy (former - to 2009)
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	11 Sep 2024 14:30
Last Modified:	25 Sep 2024 18:09
URI:	https://ueaeprints.uea.ac.uk/id/eprint/96726
DOI:	10.1016/S0960-894X(01)81044-1

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