Do microbes play a role in Alzheimer's disease?

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Williams, Zoë A. P., Lang, Leonie, Nicolas, Sarah, Clarke, Gerard, Cryan, John, Vauzour, David ORCID: https://orcid.org/0000-0001-5952-8756 and Nolan, Yvonne M. (2024) Do microbes play a role in Alzheimer's disease? Microbial Biotechnology, 17 (4). ISSN 1751-7915

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Abstract

Alzheimer's disease is a complex and progressive condition that affects essential neurological functions such as memory and reasoning. In the brain, neuronal loss, synaptic dysfunction, proteinopathy, neurofibrillary tangles, and neuroinflammation are the hallmarks of Alzheimer's disease pathophysiology. In addition, recent evidence has highlighted that microbes, whether commensal or pathogenic, also have the ability to interact with their host and to regulate its immune system, therefore participating in the exchanges that lead to peripheral inflammation and neuropathology. Because of this intimate relationship, bacteria, viruses, fungi, and protozoa have been implicated in the development of Alzheimer's disease. Here, we bring together current and most recent evidence of the role of microbes in Alzheimer's disease, raising burning questions that need to be addressed to guide therapeutic approaches and potential prophylactic strategies.

Item Type:	Article
Uncontrolled Keywords:	applied microbiology and biotechnology,bioengineering,biochemistry,biotechnology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2400/2402
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?... https://sfamjournals.onlinelibrary.wiley...
Depositing User:	LivePure Connector
Date Deposited:	10 Apr 2024 11:30
Last Modified:	06 Jun 2024 15:27
URI:	https://ueaeprints.uea.ac.uk/id/eprint/94884
DOI:	10.1111/1751-7915.14462

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