Dominance reversals: the resolution of genetic conflict and maintenance of genetic variation

Grieshop, Karl ORCID: https://orcid.org/0000-0001-8925-5066, Ho, Eddie K. H. and Kasimatis, Katja R. (2024) Dominance reversals: the resolution of genetic conflict and maintenance of genetic variation. Proceedings of the Royal Society B: Biological Sciences, 291 (2018). ISSN 0962-8452

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Abstract

Beneficial reversals of dominance reduce the costs of genetic trade-offs and can enable selection to maintain genetic variation for fitness. Beneficial dominance reversals are characterized by the beneficial allele for a given context (e.g. habitat, developmental stage, trait or sex) being dominant in that context but recessive where deleterious. This context dependence at least partially mitigates the fitness consequence of heterozygotes carrying one non-beneficial allele for their context and can result in balancing selection that maintains alternative alleles. Dominance reversals are theoretically plausible and are supported by mounting empirical evidence. Here, we highlight the importance of beneficial dominance reversals as a mechanism for the mitigation of genetic conflict and review the theory and empirical evidence for them. We identify some areas in need of further research and development and outline three methods that could facilitate the identification of antagonistic genetic variation (dominance ordination, allele-specific expression and allele-specific ATAC-Seq (assay for transposase-accessible chromatin with sequencing)). There is ample scope for the development of new empirical methods as well as reanalysis of existing data through the lens of dominance reversals. A greater focus on this topic will expand our understanding of the mechanisms that resolve genetic conflict and whether they maintain genetic variation.

Item Type:	Article
Additional Information:	Funding information: This research was supported by the Swedish Research Council (2018-06775 to K.G.), the University of Toronto's Faculty of Arts and Science (Postdoctoral Fellowship to K.G.) and the National Sciences and Engineering Research Council (Banting Postdoctoral Fellowship to KRK).
Uncontrolled Keywords:	antagonistic pleiotropy,balancing selection,dominance reversal,genetic conflict,genetic trade-offs,genetic variation,agricultural and biological sciences(all),environmental science(all),immunology and microbiology(all),biochemistry, genetics and molecular biology(all),3* ,/dk/atira/pure/subjectarea/asjc/1100
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation
Related URLs:	http://www.scopus.com/inward/record.url?... https://royalsocietypublishing.org/doi/1...
Depositing User:	LivePure Connector
Date Deposited:	14 Mar 2024 11:30
Last Modified:	09 Oct 2024 13:40
URI:	https://ueaeprints.uea.ac.uk/id/eprint/94678
DOI:	10.1098/rspb.2023.2816

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