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Carozza, Sofia, Holmes, Joni 
ORCID: https://orcid.org/0000-0002-6821-2793, Vértes, Petra E., Bullmore, Ed, Arefin, Tanzil M., Pugliese, Alexa, Zhang, Jiangyang, Kaffman, Arie, Akarca, Danyal and Astle, Duncan E.
(2023)
Early adversity changes the economic conditions of mouse structural brain network organization.
Developmental Psychobiology, 65 (6).
ISSN 0012-1630
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Abstract
Early adversity can change educational, cognitive, and mental health outcomes. However, the neural processes through which early adversity exerts these effects remain largely unknown. We used generative network modeling of the mouse connectome to test whether unpredictable postnatal stress shifts the constraints that govern the organization of the structural connectome. A model that trades off the wiring cost of long-distance connections with topological homophily (i.e., links between regions with shared neighbors) generated simulations that successfully replicate the rodent connectome. The imposition of early life adversity shifted the best-performing parameter combinations toward zero, heightening the stochastic nature of the generative process. Put simply, unpredictable postnatal stress changes the economic constraints that reproduce rodent connectome organization, introducing greater randomness into the development of the simulations. While this change may constrain the development of cognitive abilities, it could also reflect an adaptive mechanism that facilitates effective responses to future challenges.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: The authors would like to thank Mikail Rubinov for providing the parcellation. This work was supported by a British Marshall Scholarship to S.C., MRC intramural award G101400 to J.H., MRC program grant MC‐A060‐5PQ40 to D.E.A., and TWCF Grant 0159 to D.E.A. All research at the Department of Psychiatry in the University of Cambridge is supported by the NIHR Cambridge Biomedical Research Centre (BRC‐1215‐20014) and NIHR Applied Research Centre. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. |
| Uncontrolled Keywords: | sdg 3 - good health and well-being,3* ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Social Sciences > School of Psychology |
| UEA Research Groups: | Faculty of Social Sciences > Research Groups > Cognition, Action and Perception Faculty of Social Sciences > Research Groups > Developmental Science |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 23 Jun 2023 08:31 |
| Last Modified: | 21 Oct 2024 17:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/92485 |
| DOI: | 10.1002/dev.22405 |
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