Animal and environmental risk factors for sporadic Shiga toxin-producing Escherichia coli (STEC) infection in England: A case control study for O157, O26 and other STEC serotypes

Kintz, Erica, Brainard, Julii, Vanderes, Mike, Vivancos, Roberto, Byrne, Lisa, Butt, Saira, Jenkins, Claire, Elson, Richard ORCID: https://orcid.org/0000-0001-6350-5274, Lake, Iain ORCID: https://orcid.org/0000-0003-4407-5357 and Hunter, Paul ORCID: https://orcid.org/0000-0002-5608-6144 (2023) Animal and environmental risk factors for sporadic Shiga toxin-producing Escherichia coli (STEC) infection in England: A case control study for O157, O26 and other STEC serotypes. Pathogens and Global Health, 117 (7). pp. 655-663. ISSN 2047-7724

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Abstract

Most Shiga toxin-producing E. coli (STEC) infections are sporadic. Routine enhanced surveillance questionnaires of confirmed STEC cases in England contained promising data to conduct a case-control study to identify non-food exposures linked to the risk of becoming infected with different STEC serotypes, including O157, O26 and all others; this study pulled eligible cases from the recorded enhanced surveillance data. Controls were recruited from the general population and answered a comparable postal questionnaire. Logistic regression was performed to identify risk factors associated with STEC infection for O157, O26 and other serotype cases. In adjusted models, travel outside of the U.K. and childcare occupations raised the risk of infection for all serotypes. Day trips within the UK, exposure to dogs and contact with soil were linked to lower infection risk. Resident region within England was often linked to decreased risk. Summer season was linked to O157 and O26, but not other STEC. Swimming in the sea was linked to increased risk of infection by O157, but not other types of STEC. Correlations between exposures and infection were similar when the analysis was repeated excluding participants with a history of foreign travel. As the first case-control study in England to include sporadic non-O157 STEC, the varying risk factors between O157 and non-O157 cases suggest there are potentially unique reservoirs for different serotypes.

Item Type:	Article
Additional Information:	Funding information: The research was funded by the National Institute for Health Research Health Protection Research Units in Gastrointestinal Infections (IS-HPU-1112-10038), Emerging and Zoonotic Infections (IS-HPU-1112-10117) and Emergency Preparedness (IS-HPU-1112-10141) at Liverpool University, Kings College London and University of East Anglia, in partnership with the UK Health Security Agency.
Uncontrolled Keywords:	shiga toxin e. coli,logistic models,risk factors,case-control studies,case-control studies,public health, environmental and occupational health,infectious diseases,parasitology,microbiology ,/dk/atira/pure/subjectarea/asjc/2700/2739
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Environmental Sciences University of East Anglia Research Groups/Centres > Theme - ClimateUEA
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Science > Research Groups > Environmental Social Sciences University of East Anglia Schools > Faculty of Science > Tyndall Centre for Climate Change Research Faculty of Science > Research Centres > Tyndall Centre for Climate Change Research Faculty of Social Sciences > Research Centres > Water Security Research Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	23 Mar 2023 11:30
Last Modified:	19 Nov 2024 01:29
URI:	https://ueaeprints.uea.ac.uk/id/eprint/91673
DOI:	10.1080/20477724.2023.2197672

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