Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Connell, Emily, Le Gall, Gwenaelle ORCID: https://orcid.org/0000-0002-1379-2196, Pontifex, Matthew G. ORCID: https://orcid.org/0000-0003-2174-2313, Sami, Saber, Cryan, John F., Clarke, Gerard, Müller, Michael ORCID: https://orcid.org/0000-0002-5930-9905 and Vauzour, David ORCID: https://orcid.org/0000-0001-5952-8756 (2022) Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia. Molecular Neurodegeneration, 17 (1). ISSN 1750-1326

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Abstract

A consequence of our progressively ageing global population is the increasing prevalence of worldwide age-related cognitive decline and dementia. In the absence of effective therapeutic interventions, identifying risk factors associated with cognitive decline becomes increasingly vital. Novel perspectives suggest that a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, commonly referred to as the microbiota-gut-brain axis, may be a contributing factor for cognitive health and disease. However, the exact mechanisms remain undefined. Microbial-derived metabolites produced in the gut can cross the intestinal epithelial barrier, enter systemic circulation and trigger physiological responses both directly and indirectly affecting the central nervous system and its functions. Dysregulation of this system (i.e., dysbiosis) can modulate cytotoxic metabolite production, promote neuroinflammation and negatively impact cognition. In this review, we explore critical connections between microbial-derived metabolites (secondary bile acids, trimethylamine-N-oxide (TMAO), tryptophan derivatives and others) and their influence upon cognitive function and neurodegenerative disorders, with a particular interest in their less-explored role as risk factors of cognitive decline.

Item Type:	Article
Additional Information:	Funding Information: Figures created with BioRender.com. Publisher Copyright: © 2022, The Author(s).
Uncontrolled Keywords:	alzheimer’s disease,bile acids,brain,cresols,indoles,microbiota-gut-brain axis,tmao,tryptophan,molecular biology,clinical neurology,cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?... https://molecularneurodegeneration.biome...
Depositing User:	LivePure Connector
Date Deposited:	20 Jun 2022 10:30
Last Modified:	06 Jun 2024 15:18
URI:	https://ueaeprints.uea.ac.uk/id/eprint/85699
DOI:	10.1186/s13024-022-00548-6

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