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Zhang, Yinlong, Wei, Jingyan, Xu, Jiaqi, Leong, Wei Sun, Liu, Guangna, Ji, Tianjiao, Cheng, Zhiqiang, Wang, Jing, Lang, Jiayan, Zhao, Ying, You, Linhao, Zhao, Xiao, Wei, Taotao, Anderson, Greg J., Qi, Sheng 
ORCID: https://orcid.org/0000-0003-1872-9572, Kong, Jing, Nie, Guangjun and Li, Suping
(2018)
Suppression of tumor energy supply by liposomal nanoparticle-mediated inhibition of aerobic glycolysis.
ACS Applied Materials & Interfaces, 10 (3).
2347–2353.
ISSN 1944-8244
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Abstract
Aerobic glycolysis enables cancer cells to rapidly take up nutrients (e.g., nucleotides, amino acids, and lipids) and incorporate them into the biomass needed to produce a new cell. In contrast to existing chemotherapy/radiotherapy strategies, inhibiting aerobic glycolysis to limit the adenosine 5′-triphosphate (ATP) yield is a highly efficient approach for suppressing tumor cell proliferation. However, most, if not all, current inhibitors of aerobic glycolysis cause significant adverse effects because of their nonspecific delivery and distribution to nondiseased organs, low bioavailability, and a narrow therapeutic window. New strategies to enhance the biosafety and efficacy of these inhibitors are needed for moving them into clinical applications. To address this need, we developed a liposomal nanocarrier functionalized with a well-validated tumor-targeting peptide to specifically deliver the aerobic glycolysis inhibitor 3-bromopyruvate (3-BP) into the tumor tissue. The nanoparticles effectively targeted tumors after systemic administration into tumor-bearing mice and suppressed tumor growth by locally releasing 3-BP to inhibit the ATP production of the tumor cells. No overt side effects were observed in the major organs. This report demonstrates the potential utility of the nanoparticle-enabled delivery of an aerobic glycolysis inhibitor as an anticancer therapeutic agent.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 3-bromopyruvate,atp,liposomal nanoparticles,tumor-targeting peptide,warburg effect,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Jul 2018 15:32 |
| Last Modified: | 12 Dec 2024 01:43 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/67727 |
| DOI: | 10.1021/acsami.7b16685 |
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