Electrospun polymer blend nanofibers for tuneable drug delivery: the role of transformative phase separation on controlling the release rate

Tipduangta, Pratchaya, Belton, Peter, Fabian, Laszlo, Wang, Li Ying, Tang, Huiru, Eddleston, Mark and Qi, Sheng ORCID: https://orcid.org/0000-0003-1872-9572 (2016) Electrospun polymer blend nanofibers for tuneable drug delivery: the role of transformative phase separation on controlling the release rate. Molecular Pharmaceutics, 13 (1). pp. 25-39. ISSN 1543-8384

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Abstract

Electrospun fibrous materials have a wide range of biomedical applications, many of them involving the use of polymers as matrices for incorporation of therapeutic agents. The use of polymer blends improves the tuneability of the physicochemical and mechanical properties of the drug loaded fibres. This also benefits the development of controlled drug release formulations, for which the release rate can be modified by altering the ratio of the polymers in the blend. However, to realise these benefits, a clear understanding of the phase behaviour of the processed polymer blend is essential. This study reports an in depth investigation of the impact of the electrospinning process on the phase separation of a model partially miscible polymer blend, PVP K90 and HPMCAS, in comparison to other conventional solvent evaporation based processes including film casting and spin coating. The nanoscale stretching and ultrafast solvent removal of electrospinning lead to an enhanced apparent miscibility between the polymers, with the same blends showing micron scale phase separation when processed using film casting and spin coating. Nanoscale phase separation in electrospun blend fibres was confirmed in the dry state. Rapid, layered, macro-scale phase separation of the two polymers occurred during the wetting of the fibres. This led to a biphasic drug release profile from the fibres, with a burst release from PVP-rich phases and a slower, more continuous release from HPMCAS-rich phases. It was noted that the model drug, paracetamol, had more favourable partitioning into the PVP-rich phase, which is likely to be a result of greater hydrogen bonding between PVP and paracetamol. This led to higher drug contents in the PVP-rich phases than the HPMCAS-rich phases. By alternating the proportions of the PVP and HPMCAS, the drug release rate can be modulated.

Item Type:	Article
Uncontrolled Keywords:	phase separation,polymer blends,electrospinning,tuneable drug release
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024) Faculty of Science > School of Chemistry (former - to 2024) Faculty of Science
UEA Research Groups:	Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017) Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User:	Pure Connector
Date Deposited:	06 Jan 2016 13:01
Last Modified:	05 Oct 2024 23:47
URI:	https://ueaeprints.uea.ac.uk/id/eprint/56076
DOI:	10.1021/acs.molpharmaceut.5b00359

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