Semantic deficits in amyotrophic lateral sclerosis

Leslie, Felicity V. C., Hsieh, Sharpley, Caga, Jashelle, Savage, Sharon A., Mioshi, Eneida, Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788, Kiernan, Matthew C., Hodges, John R and Burrell, James R. (2015) Semantic deficits in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 16 (1-2). pp. 46-53. ISSN 2167-8421

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Abstract

Objective: To investigate, and establish neuroanatomical correlates of, semantic deficits in amyotrophic lateral sclerosis (ALS) and amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD), compared to semantic dementia (SD) and controls. Methods: Semantic deficits were evaluated using a naming and semantic knowledge composite score, comprising of verbal and non-verbal neuropsychological measures of single-word processing (confrontational naming, comprehension, and semantic association) from the Sydney Language Battery (SYDBAT) and Addenbrooke’s Cognitive Examination - Revised (ACE-R). Voxel-based morphometry (VBM) analysis was conducted using the region of interest approach. Results: In total, 84 participants were recruited from a multidisciplinary research clinic in Sydney. Participants included 17 patients with ALS, 19 patients with ALS-FTD, 22 patients with SD and 26 age- and education- matched healthy controls. Significant semantic deficits were observed in ALS and ALS-FTD compared to controls. The severity of semantic deficits varied across the clinical phenotypes; ALS patients were less impaired than ALS-FTD patients, who in turn were not as impaired as SD patients. Anterior temporal lobe atrophy significantly correlated with semantic deficits. Conclusion: Semantic impairment is a feature of ALS and ALS-FTD, and reflects the severity of temporal lobe pathology.

Item Type:	Article
Uncontrolled Keywords:	cognitive impairment,als-ftd,semantic
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Mental Health Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	Pure Connector
Date Deposited:	04 Jan 2016 12:00
Last Modified:	19 Oct 2023 01:34
URI:	https://ueaeprints.uea.ac.uk/id/eprint/55925
DOI:	10.3109/21678421.2014.987301

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