Thermal Analysis by Structural Characterization (TASC) as a novel method for assessing heterogeneity in complex solid pharmaceutical dosage forms

Alhijjaj, Muqdad, Reading, Mike, Belton, Peter and Qi, Sheng ORCID: https://orcid.org/0000-0003-1872-9572 (2015) Thermal Analysis by Structural Characterization (TASC) as a novel method for assessing heterogeneity in complex solid pharmaceutical dosage forms. Analytical Chemistry, 87 (21). 10848–10855. ISSN 0003-2700

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Abstract

Characterizing inter- and intrasample heterogeneity of solid and semisolid pharmaceutical products is important both for rational design of dosage forms and subsequent quality control during manufacture; however, most pharmaceutical products are multicomponent formulations that are challenging in this regard. Thermal analysis, in particular differential scanning calorimetry, is commonly used to obtain structural information, such as degree of crystallinity, or identify the presence of a particular polymorph, but the results are an average over the whole sample; it cannot directly provide information about the spatial distribution of phases. This study demonstrates the use of a new thermo-optical technique, thermal analysis by structural characterization (TASC), that can provide spatially resolved information on thermal transitions by applying a novel algorithm to images acquired by hot stage microscopy. We determined that TASC can be a low cost, relatively rapid method of characterizing heterogeneity and other aspects of structure. In the examples studied, it was found that high heating rates enabled screening times of 3–5 min per sample. In addition, this study demonstrated the higher sensitivity of TASC for detecting the metastable form of polyethylene glycol (PEG) compared to conventional differential scanning calorimetry (DSC). This preliminary work suggests that TASC will be a worthwhile additional tool for characterizing a broad range of materials.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Faculty of Science
Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017)
Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017)
Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
Depositing User: Pure Connector
Date Deposited: 06 Nov 2015 00:03
Last Modified: 21 Oct 2022 01:20
URI: https://ueaeprints.uea.ac.uk/id/eprint/55007
DOI: 10.1021/acs.analchem.5b02192

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