A new low melting-point polymorph of Fenofibrate prepared via talc induced heterogeneous nucleation

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Tipduangta, Pratchaya, Takieddin, Khaled, Fabian, Laszlo, Belton, Peter and Qi, Sheng ORCID: https://orcid.org/0000-0003-1872-9572 (2015) A new low melting-point polymorph of Fenofibrate prepared via talc induced heterogeneous nucleation. Crystal Growth & Design, 15 (10). 5011–5020. ISSN 1528-7483

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Abstract

Fenofibrate is one of the most commonly prescribed hyperlipidemia agents. Despite its high lipophilicity and ultralow aqueous solubility, most commercially available formulations use micronized crystalline fenofibrate form I, which has a low dissolution rate and poor oral bioavailability. Little is known about the crystallization of other polymorphs from supercooled amorphous fenofibrate. This study reports a new fenofibrate polymorph (form III) obtained via a controlled heterogeneous nucleation method using low quantity (1% w/w) of the generally recognized as safe (GRAS) oral pharmaceutical excipient talc. Form III has a low melting point of 50 °C, and crystallization of form I immediately occurs after the melting of form III. The microscopic, thermal, and spectroscopic characterizations of form III confirmed the distinct molecular packing difference between the new form and other known forms. The discovery of this new form will enrich the understanding of the molecular behavior of fenofibrate and bring useful insights into the role pharmaceutical excipients in selective crystallization of pharmaceutical active ingredients.

Item Type: Article
Uncontrolled Keywords: fenofibrate,amorphous,heterogeneous nucleation,talc,polymorph
Faculty \ School: Faculty of Science > School of Pharmacy (former - to 2024)
Faculty of Science > School of Chemistry (former - to 2024)
Faculty of Science
UEA Research Groups: Faculty of Science > Research Groups > Drug Delivery and Pharmaceutical Materials (former - to 2017)
Faculty of Science > Research Groups > Biophysical Chemistry (former - to 2017)
Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
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Depositing User: Pure Connector
Date Deposited: 21 Oct 2015 16:00
Last Modified: 24 Sep 2024 11:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/54743
DOI: 10.1021/acs.cgd.5b00956

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