A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer

Stephens, Philip, Edkins, Sarah, Davies, Helen, Greenman, Christopher, Cox, Charles, Hunter, Chris, Bignell, Graham, Teague, Jon, Smith, Raffaella, Stevens, Claire, O'Meara, Sarah, Parker, Adrian, Tarpey, Patrick, Avis, Tim, Barthorpe, Andy, Brackenbury, Lisa, Buck, Gemma, Butler, Adam, Clements, Jody, Cole, Jennifer, Dicks, Ed, Edwards, Ken, Forbes, Simon, Gorton, Matthew, Gray, Kristian, Halliday, Kelly, Harrison, Rachel, Hills, Katy, Hinton, Jonathon, Jones, David, Kosmidou, Vivienne, Laman, Ross, Lugg, Richard, Menzies, Andrew, Perry, Janet, Petty, Robert, Raine, Keiran, Shepherd, Rebecca, Small, Alexandra, Solomon, Helen, Stephens, Yvonne, Tofts, Calli, Varian, Jennifer, Webb, Anthony, West, Sofie, Widaa, Sara, Yates, Andrew, Brasseur, Francis, Cooper, Colin S ORCID: https://orcid.org/0000-0003-2013-8042, Flanagan, Adrienne M, Green, Anthony, Knowles, Maggie, Leung, Suet Y, Looijenga, Leendert H J, Malkowicz, Bruce, Pierotti, Marco A, Teh, Bin, Yuen, Siu T, Nicholson, Andrew G, Lakhani, Sunil, Easton, Douglas F, Weber, Barbara L, Stratton, Michael R, Futreal, P Andrew and Wooster, Richard (2005) A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nature Genetics, 37 (6). pp. 590-592. ISSN 1061-4036

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Abstract

We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.

Item Type:	Article
Uncontrolled Keywords:	aged,breast neoplasms,carcinoma, ductal, breast,dna mutational analysis,female,humans,multigene family,mutation,protein kinases,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Computing Sciences Faculty of Medicine and Health Sciences > School of Rehabilitation Sciences (former - to 2014) Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Science > Research Groups > Computational Biology Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User:	Pure Connector
Date Deposited:	06 Jan 2014 14:58
Last Modified:	23 Apr 2023 00:23
URI:	https://ueaeprints.uea.ac.uk/id/eprint/46160
DOI:	10.1038/ng1571

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