Pilot randomised controlled trial of occupational therapy to optimise independence in Parkinson's disease: the PD OT Trial

Clarke, C E, Furmston, A, Morgan, E, Patel, S, Sackley, C, Walker, M, Bryan, S and Wheatley, K (2009) Pilot randomised controlled trial of occupational therapy to optimise independence in Parkinson's disease: the PD OT Trial. Journal of Neurology, Neurosurgery and Psychiatry, 80 (9). pp. 976-978. ISSN 1468-330X

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Abstract

To perform a pilot trial of occupational therapy (OT) to optimise functional independence in Parkinson disease (PD) to assess accrual/withdrawal rates, acceptability, outcome measures, and inform sample-size calculation. Non-demented patients with idiopathic PD and difficulties with activities of daily living (ADL) were recruited provided they had not received OT in the last 2 years and/or physiotherapy in the last year. Patients were randomised to immediate OT or OT after completion of the trial. Patients randomised to OT were assessed at home by an experienced therapist and then received six home treatment sessions over 2 months. Interventions were targeted at functional independence and mobility goals. Outcome measures were: Nottingham Extended Activity of Daily Living Scale, Rivermead Mobility Index, Unified Parkinson's Disease Rating Scale ADL scale, Parkinson's Disease Questionnaire 39, EuroQol-EQ-5D, Hospital Anxiety and Depression Scale, and health economics analysis. 39 patients (25 male; mean age 73 years) were recruited from four centres over 16 months. The mean difference in NEADL at 8 months was 3.5 (95% CI -3.2 to 10.2). The mean difference in PDQ-39 Summary Score was 3.8 (95% CI -4.94 to 12.6). There were strong correlations between the PDQ-39 and other outcomes. The intervention was acceptable to patients, with a low withdrawal rate and good questionnaire completion. Randomisation to a trial of OT in PD is feasible. NEADL and PDQ-39 are relevant outcomes and provided data to inform sample size for an adequately powered randomised trial for which there is pressing need.

Item Type:	Article
Uncontrolled Keywords:	depression,anxiety,parkinson disease,occupational therapy,humans,treatment outcome,aged,activities of daily living,pilot projects,male,female
Faculty \ School:	Faculty of Medicine and Health Sciences > School of Rehabilitation Sciences (former - to 2014)
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Rehabilitation
Depositing User:	Pure Connector
Date Deposited:	10 Sep 2013 05:39
Last Modified:	17 May 2023 00:49
URI:	https://ueaeprints.uea.ac.uk/id/eprint/43224
DOI:	10.1136/jnnp.2007.138586

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