Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes

Bew, Sean P. ORCID: https://orcid.org/0000-0002-9087-9463, Brimage, Rebecca A., Hughes, David L., Legentil, Laurent, Sharma, Sunil V. and Wilson, Martin A. (2007) Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes. The Journal of Organic Chemistry, 72 (7). pp. 2655-2658.

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An efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported. © 2007 American Chemical Society.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Science > School of Chemical Sciences and Pharmacy (former - to 2009)
UEA Research Groups: Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Faculty of Science > Research Groups > Synthetic Chemistry (former - to 2017)
Related URLs:
Depositing User: Rachel Smith
Date Deposited: 15 Feb 2011 10:07
Last Modified: 15 Dec 2022 16:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/21371
DOI: 10.1021/jo062114k

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