Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes

Bew, S.P., Brimage, R.A., Hughes, D.L., Legentil, L., Sharma, S.V. and Wilson, M.A. (2007) Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes. The Journal of Organic Chemistry, 72 (7). pp. 2655-2658.

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An efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported. © 2007 American Chemical Society.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry

Faculty of Science > School of Chemical Sciences and Pharmacy
Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Rachel Smith
Date Deposited: 15 Feb 2011 10:07
Last Modified: 27 Apr 2022 19:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/21371
DOI: 10.1021/jo062114k

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