Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes

Bew, S.P. ORCID: https://orcid.org/0000-0002-9087-9463, Brimage, R.A., Hughes, D.L., Legentil, L., Sharma, S.V. and Wilson, M.A. (2007) Expedient synthesis of substituted (diphenylphosphinoylmethyl)benzenes. The Journal of Organic Chemistry, 72 (7). pp. 2655-2658.

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Abstract

An efficient protocol for the synthesis of structurally diverse (diphenylphosphinoylmethyl)benzenes is described. The reaction employs readily available carboxylic acids, chlorodiphenylphosphine, and water as the reagents. A 97% reduction in the reaction times and substantially higher yields of products result, up to a 60% increase, if the reactions are performed under microwave irradiation. The first examples of transition-metal-catalyzed reactions applied to 4-bromo-1,3-bis(diphenylphosphinoylmethyl)benzene are also reported. © 2007 American Chemical Society.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry

Faculty of Science > School of Chemical Sciences and Pharmacy
Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Rachel Smith
Date Deposited: 15 Feb 2011 10:07
Last Modified: 24 Oct 2022 01:13
URI: https://ueaeprints.uea.ac.uk/id/eprint/21371
DOI: 10.1021/jo062114k

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