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ToolsHast, Marisa, Baker-Austin, Craig, Lake, Iain, Paromita, Pritiza, Cui, Zhaohui, Jones, Natalia R., Posen, Paulette and Hughes, Michael J. (2026) Vibrio vulnificus epidemiology and risk factors for mortality in the United States, 2000-2022. Infectious Diseases, 58 (2). pp. 209-220. ISSN 2374-4243
Full text not available from this repository. (Request a copy)Abstract
Background: Vibrio vulnificus is a foodborne and waterborne pathogen causing substantial morbidity and mortality; however, its epidemiology remains poorly understood. To inform prevention and control efforts, we characterized U.S. V. vulnificus epidemiology and identified risk factors for mortality. Methods: For all culture-confirmed V. vulnificus cases reported to the Cholera and Other Vibrio Illness Surveillance (COVIS) system from 2000 to 2022, patient characteristics and medical outcomes were described by foodborne vs. non-foodborne transmission routes. Risk factors for mortality were identified using multivariate logistic regression. Results: Two thousand nine hundred and eighty-nine V. vulnificus cases were reported from 2000 to 2022, including 656 (22%) foodborne and 1,619 (54%) non-foodborne cases. Five-year case total increased 70% from 2000–2004 (n = 487) to 2018–2022 (n = 827). Most patients were male, older and White, with reported underlying health conditions; 2,493 (83%) patients were hospitalized and 692 (23%) died. Number of deaths (260 vs. 200) and fatality rate (40% vs. 12%) were higher among foodborne vs. non-foodborne cases. Mortality was associated with history of liver disease/alcoholism (odds ratio (OR) = 6.5, p < 0.001), age 45–59 (OR = 11.3, p = 0.001), foodborne transmission (OR = 1.3, p = 0.006), and Black (OR = 1.8, p = 0.03) or Asian (OR = 2.5, p = 0.009) race. Antibiotic use was protective (OR = 0.33, p = 0.001). Liver disease associated with diabetes had lower mortality than other forms of liver disease (interaction OR = 0.5, p = 0.04). Conclusions: V. vulnificus infections confer a substantial and increasing public health burden in the United States. Non-foodborne transmission caused 2.5 times more cases, and foodborne transmission caused 30% more deaths and had >3 times higher fatality rate. Identifying risk factors for mortality can inform public health and medical interventions.
| Item Type: | Article |
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| Additional Information: | Publisher Copyright: ©, This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 USC. 105, no copyright protection is available for such works under US Law. |
| Uncontrolled Keywords: | vibrio vulnificus,epidemiology,foodborne illness,vibriosis,wound exposure,microbiology (medical),infectious diseases,immunology and microbiology(all) ,/dk/atira/pure/subjectarea/asjc/2700/2726 |
| Faculty \ School: | Faculty of Science > School of Environmental Sciences University of East Anglia Research Groups/Centres > Theme - ClimateUEA Faculty of Science |
| UEA Research Groups: | Faculty of Science > Research Groups > Collaborative Centre for Sustainable Use of the Seas Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation University of East Anglia Schools > Faculty of Science > Tyndall Centre for Climate Change Research Faculty of Science > Research Centres > Tyndall Centre for Climate Change Research Faculty of Science > Research Groups > Environmental Social Sciences |
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| Depositing User: | LivePure Connector |
| Date Deposited: | 11 Mar 2026 14:30 |
| Last Modified: | 15 Mar 2026 06:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/102304 |
| DOI: | 10.1080/23744235.2025.2559883 |
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