Temperature-controlled electrospinning of EVOH nanofibre mats encapsulated with Ag, CuO, and ZnO particles for skin wound dressing

Liu, Dandan, Zhang, Chuanwei, Dong, Guirong, Xu, Chao, Liu, Dianzi, Lv, Yuan, Zhong, Bin and Wang, Bin (2019) Temperature-controlled electrospinning of EVOH nanofibre mats encapsulated with Ag, CuO, and ZnO particles for skin wound dressing. Materials Research Express, 6 (1). ISSN 2053-1591

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    Abstract

    To treat skin burns, a new wound dressing, nanofibre mats with metal or metal oxide nanoparticles (Ag, CuO, and ZnO), was fabricated using the electrospinning technique. During a therapeutic process, the antibacterial ability and bio-compatibility of a new dressing material are of major concern. To expound the characteristics of ethylene vinyl alcohol (EVOH) nanofibre mats encapsulated with metal or metal oxide nanoparticles, denoted as Ag-EVOH, CuO-EVOH, and ZnO-EVOH, for use as new wound dressing materials, we investigated the suitable processing parameters to fabricate these materials, such as the voltage, tip-to-collector distance, concentration of the solution, and effect of environmental temperature. The antibacterial ability and bio-compatibility of Ag-EVOH, CuO-EVOH, and ZnO-EVOH were then tested and quantified. The outcomes show that the most suitable temperature for the fabrication of the materials is 40 °C (±3 °C). The antibacterial experiment results indicate that 0.08 g/ml of metal/metallic oxide shows the highest antibacterial ability toward Staphylococcus aureus. Furthermore, the largest diameters of the bacteriostatic loops of the three types of nanofibre mats, i.e. Ag-EVOH, CuO-EVOH, and ZnO-EVOH, are 5.89, 5.21, and 4.12 mm, respectively. Finally, the cell proliferations on the three nanofibre mats show a similar growth trend.

    Item Type: Article
    Faculty \ School: Faculty of Science > School of Mathematics
    Depositing User: LivePure Connector
    Date Deposited: 27 Sep 2018 09:30
    Last Modified: 09 Apr 2019 13:46
    URI: https://ueaeprints.uea.ac.uk/id/eprint/68372
    DOI: 10.1088/2053-1591/aae467

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