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ToolsZhang, Xu, Ning, Zhibin, Mayne, Janice and Figeys, Daniel (2025) Clinical Microbiome Analysis by Mass Spectrometry–Based Metaproteomics. Annual Review of Analytical Chemistry, 18 (1). pp. 149-172. ISSN 1936-1327
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Abstract
Mass spectrometry–based proteomics and metaproteomics have long been used in the study of human microbiomes, with the potential of metaproteomics only recently being fully harnessed. This progress is due to the advancements of high-performance mass spectrometers, innovative proteomics strategies, and the development of dedicated bioinformatics tools. In this review, we critically examine the recent technological developments that enhance the application of metaproteomics in clinical microbiome analysis. We also summarize significant advancements in the application of metaproteomics to study human microbiomes across various body sites under disease conditions. Despite these, the potential of metaproteomics remains underutilized due to typically small sample sizes and insufficient data mining. We thereby highlight some key aspects that could facilitate the broader and more effective application of mass spectrometry–based metaproteomics in clinical microbiome analysis, including the development of microbiome assays for translational research and application.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | bioinformatics,clinical application,data-independent acquisition,mass spectrometry,metaproteomics,microbiome,analytical chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1600/1602 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 23 Jul 2025 15:30 |
| Last Modified: | 14 Aug 2025 01:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/99986 |
| DOI: | 10.1146/annurev-anchem-071124-113819 |
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